Cancer of unknown primary site

Gallagher, Chris; Reznek, Rodney H.

doi:10.7861/clinmedicine.8-4-451

Cited by 3 publications

(3 citation statements)

References 27 publications

(34 reference statements)

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“…Both the pancreas and lung have been described to be the most common primary sites among cancers of unknown primary (15,16). Although anaplastic carcinomas are typically very aggressive, we cannot deny the possibility that the abdominal mass had metastasized, even though the primary cancer nest had disappeared.…”

Section: Discussionmentioning

confidence: 87%

Anaplastic Carcinoma Possibly Arising from a Heterotopic Pancreas

Adachi¹,

Mitsuya²,

Takahashi³

et al. 2015

Intern. Med.

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Anaplastic carcinoma is a rare pancreatic cancer, and the malignant transformation of a heterotopic pancreas is also rare. We herein report a case of an elderly woman with a mass of unknown origin in the abdominal cavity. Computed tomography identified the extent of the tumor but not the organ of origin. The abdominal tumor eventually metastasized to the liver and lung. An autopsy and immunohistochemical examination revealed an anaplastic carcinoma possibly originating in an ectopic pancreas.

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Section: Discussionmentioning

confidence: 87%

Anaplastic Carcinoma Possibly Arising from a Heterotopic Pancreas

Adachi¹,

Mitsuya²,

Takahashi³

et al. 2015

Intern. Med.

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“…There are several possible explanations as to why these tumors were found particularly after CUP. First, the common primary sites for CUP are the lung, pancreas, ovary, kidney, colorectum, and liver (Briasoulis and Pavlidis, 1997;Gallagher and Reznek, 2008;Matsubara et al, 2010), thereby resulting in more diagnostic activities in these anatomic sites to find tumors. Second, CT scans of the thorax, abdomen, or pelvis are recommended for all CUP patients (Pavlidis et al, 2010), yielding a relatively high detection rate of tumors in these sites.…”

Section: Discussionmentioning

confidence: 99%

Second primary cancers after cancer of unknown primary in Sweden and Germany

Líu¹,

Hemminki²,

Sundquist

et al. 2013

European Journal of Cancer Prevention

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In unsparing efforts to find the hidden primaries, second primary cancers (SPCs) unrelated to cancer of unknown primary (CUP) are found. The detection rates of SPCs after CUP can be considered as measures for the effectiveness of modern diagnostic techniques in finding tumors. We aimed to compare the rates of specific SPCs found after the work-up of CUP and the more sign/symptom-directed diagnostic approaches applied after any other cancer. The number of CUP patients identified in the nationwide Swedish database and nine German cancer registries was 24 641 from 1997 through 2006, and rate ratios (RRs) for SPCs were recorded in two follow-up periods. The detection rate of SPCs immediately after any other cancer was about two times higher in Germany than in Sweden, but the rate immediately after CUP was almost the same for the two datasets. In the joint analyses after CUP, the RRs of liver, lung, breast, and kidney cancers were higher than after any other cancer, whereas the RRs of prostate, urinary bladder, and connective tissue cancers as well as non-Hodgkin's lymphoma were not significantly different; the RR of cancers of upper aerodigestive tract was lower after CUP than after any other cancer. The joint data indicate that the work-up is efficient in detecting tumors in the thoracoabdominal organs that are screened by computed tomography. For some other organ sites, the more sign/symptom-directed diagnostic approaches may be equally efficient. However, none of the applied techniques could detect all tumors immediately after the first diagnosis.

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“…CUP accounts for 3%-7% of all malignant tumors and shows a slight male predominance [1] . The most common site of CUP is a lymph node, followed by a bone, other abdominal sites, liver, lung, pleura, central nervous system, skin, and adrenal gland; metastatic adenocarcinoma is the most common histological type [2] . Overall survival is generally poor and depends on the primary tumor [3] .…”

Section: Introductionmentioning

confidence: 99%

A case of pelvic squamous cell carcinoma of unknown primary origin that responded well to radiotherapy and nivolumab

Koge,

Hino,

Kakiuchi

et al. 2024

Radiology Case Reports

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Cancer of unknown primary site

Cited by 3 publications

References 27 publications

Anaplastic Carcinoma Possibly Arising from a Heterotopic Pancreas

Anaplastic Carcinoma Possibly Arising from a Heterotopic Pancreas

Second primary cancers after cancer of unknown primary in Sweden and Germany

A case of pelvic squamous cell carcinoma of unknown primary origin that responded well to radiotherapy and nivolumab

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