Cancer of Unknown Primary

Freudenberg, Lutz S.; Rosenbaum-Krumme, Sandra; Bockisch, Andreas; Eberhardt, Wilfried; Frilling, Andrea

doi:10.1007/978-3-540-31203-1_15

Cited by 19 publications

(15 citation statements)

References 43 publications

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“…1 CUP involving cervical lymphatics is a potentially curable condition. Histologic examination reveals a squamous cell carcinoma in most cases, followed in frequency by adenocarcinoma, anaplastic carcinoma, lymphoepithelial carcinoma, and melanoma.…”

Section: Introductionmentioning

confidence: 99%

Impact of Distant Metastasis in Patients with Cervical Lymph Node Metastases from Cancer of an Unknown Primary Site

Rödel

Matthias²,

Blomeyer³

et al. 2009

Ann Otol Rhinol Laryngol

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Section: Introductionmentioning

confidence: 99%

Impact of Distant Metastasis in Patients with Cervical Lymph Node Metastases from Cancer of an Unknown Primary Site

Rödel

Matthias²,

Blomeyer³

et al. 2009

Ann Otol Rhinol Laryngol

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“…4,5,8 The reported sensitivity and specificity of PET varied widely. Each study had its own mix of metastatic foci, histologic tumor types, and data definitions.…”

Section: Pet Imagingmentioning

confidence: 97%

“…6,7 In patients with HNCUP, the primary tumor is detected in fewer than 40% of patients with workup, and in 80% of patients at autopsy. 8 Identification of a primary site permits the clinician to tailor the therapy to address only the involved area. This allows for potential surgical treatment of disease, as well as modification of the radiation fields and thus potential reduction of radiation side effects.…”

Section: Introductionmentioning

confidence: 99%

Positron Emission Tomography in Head and Neck Squamous Cell Carcinoma of Unknown Primary

Kinder

Yao

2012

PET Clinics

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“…The finding of a metastasis usually results in a diagnostic workup, aiming at the detection of the primary tumor and defining the extent of disease. This includes radiological, laboratory, endoscopic, and other examinations as well as profound immunohistochemical profiling of a biopsy [1,2].…”

Section: Introductionmentioning

confidence: 99%

Comparison of histopathological and gene expression-based typing of cancer of unknown primary

et al. 2009

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For the clinical diagnosis and appropriate therapy of patients with cancer of unknown primary (CUP), biopsies of the tumor metastases are generally examined histopathologically and by immunohistochemistry (IHC). Gene expression profiling (GEP) is a new diagnostic technique that might further contribute to tumor specification. Biopsies of 43 CUP cases underwent a retrospective central histopathological and immunohistochemical review and centrally performed GEP using CupPrint(TM). Two samples could not be evaluated by IHC due to small biopsy size or loss of immunoreactivity. One of these and 17 other samples were not suited for GEP due to RNA degradation. In 13 out of the remaining 24 cases (54%), the same primary was proposed by IHC and GEP and was supported by the clinical findings, furthermore leading to the doubtless identification of the primary in four out of these. In seven cases, there was discordance between IHC and GEP, with the clinical picture being more in line with IHC in three and with GEP in four cases. Four cases had to remain undecided because the primary tumors suggested by IHC and GEP were not supported. In conclusion, overlap between IHC and GEP results and the clinical presentation was noted in the majority of those true CUP cases that were evaluable with both techniques. Therefore, GEP can be a complementary diagnostic technique assisting immunohistochemical profiling of cancer biopsies with unknown primary.

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Cancer of Unknown Primary

Cited by 19 publications

References 43 publications

Impact of Distant Metastasis in Patients with Cervical Lymph Node Metastases from Cancer of an Unknown Primary Site

Impact of Distant Metastasis in Patients with Cervical Lymph Node Metastases from Cancer of an Unknown Primary Site

Positron Emission Tomography in Head and Neck Squamous Cell Carcinoma of Unknown Primary

Comparison of histopathological and gene expression-based typing of cancer of unknown primary

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