Cancer-on-a-chip systems at the frontier of nanomedicine

Zhang, Yu Shrike; Zhang, Yinan; Zhang, Weijia

doi:10.1016/j.drudis.2017.03.011

Cited by 113 publications

(90 citation statements)

References 72 publications

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“…Recapitulating this microenvironment is a crucial component to understanding the fundamental pathophysiology of cancer cell migration in vivo 41 . However, this complexity is often oversimplified by conventional cell culture assays 42,43 or is mismatched by different model species 44,45 . Here, we demonstrate the 3D interstitial migration of MCF7/GFP cells through either COL1 or COL1/MAT in vitro (Fig.…”

Section: Resultsmentioning

confidence: 99%

Hydrophobic Patterning‐Based 3D Microfluidic Cell Culture Assay

Han

Kim

et al. 2018

Adv Healthcare Materials

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Engineering physiologically relevant in vitro models of human organs remains a fundamental challenge. Despite significant strides made within the field, many promising organ-on-a-chip models fall short in recapitulating cellular interactions with neighboring cell types, surrounding extracellular matrix (ECM), and exposure to soluble cues due, in part, to the formation of artificial structures that obstruct >50% of the surface area of the ECM. Here, a 3D cell culture platform based upon hydrophobic patterning of hydrogels that is capable of precisely generating a 3D ECM within a microfluidic channel with an interaction area >95% is reported. In this study, for demonstrative purposes, type I collagen (COL1), Matrigel (MAT), COL1/MAT mixture, hyaluronic acid, and cell-laden MAT are formed in the device. Three potential applications are demonstrated, including creating a 3D endothelium model, studying the interstitial migration of cancer cells, and analyzing stem cell differentiation in a 3D environment. The hydrophobic patterned-based 3D cell culture device provides the ease-of-fabrication and flexibility necessary for broad potential applications in organ-on-a-chip platforms.

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Section: Resultsmentioning

confidence: 99%

Hydrophobic Patterning‐Based 3D Microfluidic Cell Culture Assay

Han

Kim

et al. 2018

Adv Healthcare Materials

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“…The combination of biomimetic cell/extracellular matrix (ECM) arrangements with microfluidic devices can be used reproduce not only the tissue microarchitecture but also the physicochemical cues under physiologically relevant conditions . As such, the organ‐on‐a‐chip systems are demonstrated to be superior to conventional planar, static cell culture strategies, providing improved accuracy in predicting human responses to pharmaceutical compounds, chemicals/toxins, and biological species …”

Section: Parameters and Constants Used For Modelingmentioning

confidence: 99%

A Foreign Body Response‐on‐a‐Chip Platform

Sharifi

Htwe

Righi

et al. 2019

Adv Healthcare Materials

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Understanding the foreign body response (FBR) and desiging strategies to modulate such a response represent a grand challenge for implant devices and biomaterials. Here, the development of a microfluidic platform is reported, i.e., the FBR-on-a-chip (FBROC) for modeling the cascade of events during immune cell response to implants. The platform models the native implant microenvironment where the implants are interfaced directly with surrounding tissues, as well as vasculature with circulating immune cells. The study demonstrates that the release of cytokines such as monocyte chemoattractant protein 1 (MCP-1) from the extracellular matrix (ECM)-like hydrogels in the bottom tissue chamber induces trans-endothelial migration of circulating monocytes in the vascular channel toward the hydrogels, thus mimicking implant-induced inflammation. Data using patient-derived peripheral blood mononuclear cells further reveal interpatient differences in FBR, highlighting the potential of this platform for monitoring FBR in a personalized manner. The prototype FBROC platform provides an enabling strategy to interrogate FBR on various implants, including biomaterials and engineered tissue constructs, in a physiologically relevant and individual-specific manner.

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“…CRISPR/Cas9) [188] safely into cells to be properly established and used efficiently. In addition, organ-on-a-chip systems will likely help expedite interaction, efficacy, and toxicology studies of nanomaterials before going for in vivo investigations or clinical trials [186, 189]. …”

Section: Discussionmentioning

confidence: 99%

Evolution and clinical translation of drug delivery nanomaterials

et al. 2017

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With the advent of technology, the role of nanomaterials in medicine has grown exponentially in the last few decades. The main advantage of such materials has been exploited in drug delivery applications, due to their effective targeting that in turn reduces systemic toxicity compared to the conventional routes of drug administration. Even though these materials offer broad flexibility based on targeting tissue, disease, and drug payload, the demand for more effective yet highly biocompatible nanomaterial-based drugs is increasing. While therapeutically improved and safe materials have been introduced in nanomedicine platforms, issues related to their degradation rates and bio-distribution still exist, thus making their successful translation for human use very challenging. Researchers are constantly improving upon novel nanomaterials that are safer and more effective not only as therapeutic agents but as diagnostic tools as well, making the research in the field of nanomedicine ever more fascinating. In this review stress has been made on the evolution of nanomaterials that have been approved for clinical applications by the United States Food and Drug Administration Agency (FDA).

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Cancer-on-a-chip systems at the frontier of nanomedicine

Cited by 113 publications

References 72 publications

Hydrophobic Patterning‐Based 3D Microfluidic Cell Culture Assay

Hydrophobic Patterning‐Based 3D Microfluidic Cell Culture Assay

A Foreign Body Response‐on‐a‐Chip Platform

Evolution and clinical translation of drug delivery nanomaterials

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