Cancer pattern among hypertensive patients in North Karelia, Finland

Lindgren, Annamarja; Nissinen, Aulikki; Tuomilehto, Jaakko; Pukkala, Eero

doi:10.1038/sj.jhh.1001834

Cited by 62 publications

(58 citation statements)

References 43 publications

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“…Also, additional research into the pathways involved in the interrelationships between hypertension, antihypertensive medication use and breast cancer is warranted. What is known about this topic K Hypertension has been linked to some cancer types including renal and endometrial cancers 7-11 K Studies on hypertension and breast cancer have produced mixed results 4,6,9,[12][13][14] What this study adds K This study supports a positive association between treated hypertension and breast cancer among women aged 50-75 years after adjusting for age, BMI, diabetes, smoking, alcohol use, menopausal status, family history of breast or ovarian cancer, age at first full-term pregnancy and education K The association between hypertension and breast cancer was observed only among women with a BMI X25 kg/m 2 K A dose-response association was observed between duration of diuretic use and breast cancer risk Abbreviation: BMI, body mass index.…”

Section: Discussionmentioning

confidence: 99%

“…Although there appears to be consistent evidence linking hypertension with both renal cancer 7,8 and endometrial cancer particularly among obese women, 9-11 the results for breast cancer have been less consistent. At least two studies have reported a positive association of hypertension with breast cancer risk, 9,12 whereas others have not reported an association with breast cancer risk 4,13,14 or mortality. 6 Because the relationship between hypertension and breast cancer risk is still unclear, we wanted to further examine this association.…”

Section: Introductionmentioning

confidence: 99%

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Hypertension, diuretics and breast cancer risk

et al. 2006

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It is unclear whether hypertension and antihypertensive medication use are associated with breast cancer. In order to examine these associations, we conducted a case-control study among women aged 50-75 years. Breast cancer cases were ascertained via a populationbased cancer registry (n ¼ 523) and controls were ascertained via random-digit-dialing (n ¼ 131). Participants completed a self-administered questionnaire which queried history of hypertension, antihypertensive medication use and risk factors. Unconditional logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (CI), adjusted for age, body mass index (BMI), diabetes, smoking, alcohol use, menopausal status, family history of breast or ovarian cancer, age at first full-term pregnancy and education.History of treated hypertension was associated with significant increased risk of breast cancer (OR, 1.77; 95% CI, 1.04-3.03) and this association appeared only in women with BMI X25 kg/m 2 (OR, 2.30; 95% CI, 1.12-4.71). Diuretic use was also associated with elevated breast cancer risk (OR, 1.79; 95% CI, 1.07-3.01). The risk associated with diuretic use increased with duration of use (P for trend, o0.01). Use of other blood pressure medications was not found to be associated with breast cancer risk. These results support a positive association between treated hypertension, diuretic use and breast cancer risk among women aged 50-75 years.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hypertension, diuretics and breast cancer risk

et al. 2006

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“…One cohort study of hypertensive patients reported an increased risk of developing pancreatic cancer for women compared with the risk in the general population (29). This is one of the largest prospective studies of pancreatic cancer to date.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Cancer and Factors Associated with the Insulin Resistance Syndrome in the Korean Cancer Prevention Study

González

Yun²,

Lee

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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There is increasing evidence that type 2 diabetes mellitus and glucose intolerance are a cause, not just a consequence, of pancreatic cancer. We examined whether other factors that characterize the insulin resistance syndrome are also risk factors for pancreatic cancer in a prospective cohort study of 631,172 men and women (ages 45+ years) who received health insurance from the Korean Medical Insurance Corporation. The biennial medical evaluations from 1992 to 1995 provided the baseline information for this study. Relative risks (RR) were estimated using proportional hazards models adjusted for age, sex, smoking, and fasting serum glucose (after excluding the first 2 years of follow-up). There were 2,194 incident cases of pancreatic cancer diagnosed in the cohort over a median follow-up of 12 years. There was no evidence that pancreatic cancer risk was associated with total cholesterol, systolic blood pressure, WBC count, or body mass index. Abnormal levels of aspartate aminotransferase and alanine aminotransferase were both associated with a moderately increased risk of developing the disease (40+ versus <20; RR, 1.33; 95% CI, 1.14-1.55; P trend = 0.05 and RR, 1.34; 95% CI, 1.16-1.56; P trend = 0.02, respectively). Excluding 6 years of followup reduced this RR (95% CI) for aspartate aminotransferase to 1.22 (1.01-1.49), but even after excluding 10 years follow-up the RR (95% CI) for alanine aminotransferase was unchanged [1.36 (1.01-1.83)]. Although fasting serum glucose has been found previously to be associated with pancreatic cancer risk in this cohort, most other factors that characterize insulin resistance syndrome were not associated with pancreatic cancer risk. The association with elevated liver enzyme levels is a novel finding that warrants further investigation. (Cancer Epidemiol Biomarkers Prev 2008;17(2):359 -64)

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“…In men, there was no association with blood pressure. The association of blood pressure with risk of renal cell cancer has been investigated in a number of cohort (Fraser et al, 1990;Grove et al, 1991;Coughlin et al, 1997;Heath et al, 1997;Chow et al, 2000;Choi et al, 2005;Flaherty et al, 2005;Fryzek et al, 2005;Lindgren et al, 2005;Schouten et al, 2005) and case -control (McLaughlin et al, 1995;Yuan et al, 1998;Shapiro et al, 1999) studies, using as principal exposure variable either recorded blood pressure or reported hypertension. In men, recorded blood pressure has shown a convincing exposure -response gradient related to renal cell cancer risk (Coughlin et al, 1997;Chow et al, 2000).…”

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confidence: 99%

Blood pressure and renal cancer risk: the HUNT Study in Norway

et al. 2007

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In a prospective study of 36 728 women and 35 688 men during 18 years of follow-up, compared to systolic pressure o130 mm Hg, levels of 130 -149, 150 -169 and X170 mm Hg in women were associated with relative risks of renal cell cancer of 1.7, 2.0 and 2.0, respectively (P for linear trend, 0.11). In men, there was no association with blood pressure. The association of blood pressure with risk of renal cell cancer has been investigated in a number of cohort (Fraser et al, 1990;Grove et al, 1991;Coughlin et al, 1997;Heath et al, 1997;Chow et al, 2000;Choi et al, 2005;Flaherty et al, 2005;Fryzek et al, 2005;Lindgren et al, 2005;Schouten et al, 2005) and case -control (McLaughlin et al, 1995;Yuan et al, 1998;Shapiro et al, 1999) studies, using as principal exposure variable either recorded blood pressure or reported hypertension. In men, recorded blood pressure has shown a convincing exposure -response gradient related to renal cell cancer risk (Coughlin et al, 1997;Chow et al, 2000). In women, however, only reported history of hypertension has been studied as the main exposure variable. In one cohort (Flaherty et al, 2005) and two case -control studies (Yuan et al, 1998;Shapiro et al, 1999), history of hypertension was associated with increased risk. Documenting the presence or the lack of an exposure -response gradient in women is important, and might promote a better probing of the underlying mechanism of the association.In this prospective study of 36 728 women and 35 688 men, we report on the association of blood pressure measured at baseline with renal cell cancer risk during 18 years of follow-up, together with that related to ever use of blood pressure medication. MATERIALS AND METHODSIn 1984, 85 100 individuals were invited to the Nord Trøndelag Health Study (the HUNT Study) in Norway, and 75 058 (88.2 percent) accepted the invitation, filled in a self-administered questionnaire, and attended a clinical examination (Holmen et al, 1991;Ellekjaer et al, 2000). Briefly, information included smoking status and standardised measurements of blood pressure, body height and weight. The study was approved by the Regional Committee for Ethics in medical research, and by the Norwegian Data Inspectorate.This study was restricted to participants without prevalent cancer who had complete information on blood pressure and body mass index. Blood pressure was measured using calibrated mercury manometers with standard cuff size (Holmen et al, 1991). We divided systolic pressure (in mm Hg) into the following categories: o130 (reference), 130 -149, 150 -169 and X170, and diastolic pressure (in mm Hg) into the following: o85 (reference), 85 -94, 95 -104 and X105. Information on use of antihypertensive medication was derived from the question 'do you use or have you ever used blood pressure medication?' Body mass index was calculated as weight (in kg) divided by the squared value of height (in metres), and grouped into four categories: o18.5, 18.5 -24.9, 25 -29.9 and X30. Information on smoking was categorised as never, former o...

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Cancer pattern among hypertensive patients in North Karelia, Finland

Cited by 62 publications

References 43 publications

Hypertension, diuretics and breast cancer risk

Hypertension, diuretics and breast cancer risk

Pancreatic Cancer and Factors Associated with the Insulin Resistance Syndrome in the Korean Cancer Prevention Study

Blood pressure and renal cancer risk: the HUNT Study in Norway

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