Cancer patterns in Nainital and adjoining districts of Uttarakhand: A one year survey

Bag, Arundhati; Rawat, Sarita; Pant, Nirdosh Kumar; Jyala, Narayan Singh; Singh, Abhishek; Pandey, Kailash Chandra

doi:10.4103/0976-9668.101911

Cited by 12 publications

(11 citation statements)

References 6 publications

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“…Similar observation has been reported by other Indian studies also [6][7][8][9]. The prevalence of respiratory system malignancies is quite variable in different parts of India.…”

Section: Discussionsupporting

confidence: 78%

Clinico-pathological profile of lung cancer in North Indian population

Bhaskar

Singh

et al. 2018

IJRDPL

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Lung cancer is the most common cancer representing approximately 12% of all new cancers. It is also the most frequent type of cancer in males and remains the most a common cause of cancer-related mortality in both sexes. An increasing incidence of lung cancer has been observed in India. We studied the clinical and pathological profile of patients with lung cancer in a tertiary care center. We performed a retrospective analysis of histopathologically proven cases of bronchogenic carcinoma admitted in our hospital. In our study we included 203 patients with confirmed cases of lung cancer. Male to female ratio was 8.2:1. The common age group being 40-60 years, 9.86% of the patients were less than 40 years old age. Smoking was found to be the main risk factor for 81.77% patients. The most frequent symptom was a cough (72.90%) followed by fever (58.12%). The most common radiological presentation was mess lesion (46.31%). The most common histopathological type was squamous cell carcinoma (SCC) (44.83%) followed by adenocarcinoma (19.78%) and small cell lung carcinoma (SCLC) (16.75%). The majority patients (73.29%) were diagnosed in the later stages of the disease (3b and 4). Squamous cell carcinoma was the most frequent histopathological form. Smoking remains the major risk factor for lung cancer.

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“…Similar observation has been reported by other Indian studies also [6][7][8][9]. The prevalence of respiratory system malignancies is quite variable in different parts of India.…”

Section: Discussionsupporting

confidence: 78%

Clinico-pathological profile of lung cancer in North Indian population

Bhaskar

Singh

et al. 2018

IJRDPL

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“…[11] Here we wanted to investigate association of GSTT1 null polymorphism and MPO promoter polymorphism with lung cancer in this region.…”

Section: Introductionmentioning

confidence: 99%

Glutathione S-transferase T1 and myeloperoxidase −463 G>A genotypes in lung cancer patients of Kumaun region

Bag¹,

Bag²,

Jeena³

et al. 2014

J Nat Sc Biol Med

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Background:Null genetic polymorphism of Glutathione S-transferase T1 (GSTT1) and -463 G>A promoter polymorphism of myeloperoxidase (MPO) were studied for association with lung cancer.Materials and Methods:In a case- control study 26 lung cancer patients and 33 healthy individuals from hilly Kumaun region of northern India were investigated. DNA was extracted from peripheral blood. GSTT1 null polymorphism was detected by duplex PCR, and MPO polymorphism was detected by performing PCR-RFLP.Results:An increased but statistically non- significant risk for lung cancer was found for GSTT1 null genotype. No association for MPO -463G>A genotype was evident.Conclusion:Further study with large sample size may reveal such association in this population.

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“…The region is infamous for its high alcohol and tobacco consumption. In fact, about a third of the male population of the region are addicted to alcohol (Bag et al, 2012). While smoking is ubiquitous, so is the habit of 'ghutka' chewing.…”

Section: Discussionmentioning

confidence: 99%

Stage-Wise Presentation of Non-Metastatic Head and Neck Cancer: an Analysis of Patients from the Kumaon Hills of India

Pandey

Revannasiddaiah²,

Pant³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Head and neck cancer without distant metastases is amenable to various modalities of treatment. However, the stage at presentation is a very important determinant for treatment success. The present study was conducted to determine the stage-wise presentation of non-metastatic head and neck cancer patients from the hilly regions in Kumaon division of Uttarakhand, India. Materials and Methods: The hospital records for non-metastatic head and neck cancer patients from the only functional cancer centre of the region for the period of two-years (January 2012-December 2013) were included. Nasopharyngeal carcinoma was excluded due to its staging system being different. Non-squamous histopathologies were also excluded. Patients hailing from nearby regions of Uttar Pradesh and Nepal were excluded, as were patients from non-hilly regions of Kumaon. Results: Of the 271 patients of head and neck cancer, 27 with distant metastases at diagnosis were excluded from the analysis. Of the 244 eligible patient records, 90.1% (n=222) were male, and 9.9% (n=22) were female. The proportions of patients with carcinoma of the larynx, oropharynx, oral cavity, hypopharynx and maxillary antrum were 31.9% (n=78), 27.9% (n=68), 20.5% (n=50), 12.7% (n=31) and 1.2% (n=3). A further 5.7% (n=14) were diagnosed as having secondary involvement of neck nodes with unknown primaries. The proportion of patients presenting in stages I, II, III, IVA and IVB were 0.8% (n=2), 2.5% (n=6), 9.4% (n=23), 51.6% (n=126) and 35.7% (n=87) respectively. Conclusions: An abysmally low proportion (3.3%) of non-metastatic head and neck cancer patients presented in the early stages (I and II). A vast majority of the patients (88.1%) presented with stages IVA and IVB. Not only does this reflect a poor therapeutic outlook, but also exposes the dire need for programmes focusing on cancer awareness and early detection in the region.Keywords: Head and neck cancer -Kumaon -cancer in the Himalayas -Uttarakhand

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Cancer patterns in Nainital and adjoining districts of Uttarakhand: A one year survey

Cited by 12 publications

References 6 publications

Clinico-pathological profile of lung cancer in North Indian population

Clinico-pathological profile of lung cancer in North Indian population

Glutathione S-transferase T1 and myeloperoxidase −463 G>A genotypes in lung cancer patients of Kumaun region

Stage-Wise Presentation of Non-Metastatic Head and Neck Cancer: an Analysis of Patients from the Kumaon Hills of India

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