Cancer photocytotoxicity and anti-inflammatory response of cis-A₂B₂ type meso-p-nitrophenyl and p-hydroxyphenyl porphyrin and its zinc(ii) complex: a synthetic alternative to the THPP synthon

Abstract

In comparison with the popular synthetic synthon THPP, the cis-A2B2 type of porphyrin derivative and its zinc(ii) complex PN2(OH)2Zn offer more promising photochemical and photobiological outcomes.

Phototherapeutic anticancer strategies with first-row transition metal complexes: a critical review

“…133 More recently, another Zn( ii ) porphyrin was reported, with an IC 50 value of 2.01 μM upon irradiation while remaining non-toxic in the dark. 134 In 2019, bis(dipyrrinato)Zn( ii ) complexes were designed as potential PDT PSs ( Zn-4 being one of them). 135 The two dipyrrinato ligands are structurally similar to “half-porphyrins”; they display comparable excited states, while avoiding classic porphyrin drawbacks such as aggregation and a tedious synthesis.…”

An Anti‐inflammatory Fe3O4‐Porphyrin Nanohybrid Capable of Apoptosis through Upregulation of p21 Kinase Inhibitor Having Immunoprotective Properties under Anticancer PDT Conditions

“…A Philips Essential Master PL-L 36W/865/4P linear compact fluorescent lamp (λ = 400-700 nm, Luminous Efficacy = 80 lm/W) placed at a distance of 10 cm was used as the irradiation source, the obtained light dosage was 50 J cm À 2 . [39][40][41] The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay is a colorimetric assay for assessing cellular metabolic activity. NAD(P)H-dependent cellular oxidoreductase enzymes may, under defined conditions, reflect the number of viable cells present in the cell culture.…”

Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms

“…Zinc is often incorporated in macrocycles, such as porphyrins and phthalocyanines (PCs). There has been much work on zinc porphyrins as PSs. − However, due to the strong absorption of porphyrins at 400–600 nm, there is a risk of skin damage in clinical applications. In contrast, phthalonitrile has a weak absorption in this range and has gained much attention in recent years.…”