Cancer prevention by carotenoids

Nishino, Hoyoku; Murakoshi, Michiaki; Tokuda, Harukuni; Satomi, Yoshiko

doi:10.1016/j.abb.2008.09.011

Cited by 218 publications

(102 citation statements)

References 6 publications

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“…In addition to their role as an important aesthetic parameter, the carotenoids have important nutritional and health roles. Some carotenoids have provitamin A activity, which provides protection from ocular diseases (Ribaya-Mercado and Blumberg 2004), and all of the carotenoids show antioxidant capacity, which reduces the risk of chronic degenerative diseases (Abdel-Aal et al 2007;Nishino et al 2009). …”

Section: Introductionmentioning

confidence: 99%

The colours of durum wheat: a review

et al. 2014

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Abstract. Pigments are essential to the life of all living organisms. Animals and plants have been the subjects of basic and applied research with the aim of determining the basis of the accumulation and physiological roles of pigments. In crop species, the edible organs show large variations in colour. In durum wheat grain, which is a staple food for humans, the colour is mainly due to two natural classes of pigment: carotenoids and anthocyanins. The carotenoids provide the yellow pigmentation of the durum wheat endosperm, and consequently of the semolina, which has important implications for the marketing of end products based on durum wheat. Anthocyanins accumulate in the aleurone or pericarp of durum wheat and provide the blue, purple and red colours of the grain. Both the carotenoids and the anthocyanins are known to provide benefits for human health, in terms of decreased risks of certain diseases. Therefore, accumulation of these pigments in the grain represents an important trait in breeding programs aimed at improving the nutritional value of durum wheat grain and its end products. This review focuses on the biochemical and genetic bases of pigment accumulation in durum wheat grain, and on the breeding strategies aimed at modifying grain colour.

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Section: Introductionmentioning

confidence: 99%

The colours of durum wheat: a review

et al. 2014

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“…The most abundant carotenoids found in human plasma are a-and b-carotene, b-cryptoxanthin, lutein, zeaxanthin, and lycopene [2]. Carotenoids have been linked to beneficial health effects including reducing the risks of certain cancers [3][4][5][6], providing antioxidant effects [7,8], and promoting immune system health [9,10]. Most importantly, a-and b-carotene and b-cryptoxanthin (collectively called pro-vitamin A carotenoids) can convert to retinol in the body [11,12].…”

Section: Introductionmentioning

confidence: 98%

Rapid Isocratic HPLC Method and Sample Extraction Procedures for Measuring Carotenoid, Retinoid, and Tocopherol Concentrations in Human Blood and Breast Milk for Intervention Studies

Turner

Burri

2012

Chromatographia

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Vitamin A deficiency continues to be a major public health concern in the developing world effecting over 200 million people. Interventions including carotenoid-rich fruits and vegetables, containing a-and b-carotene, and b-cryptoxanthin, are being tested for their potential to alleviate vitamin A deficiency in several countries. Thus, there is a need for a faster isocratic reverse-phase high pressure liquid chromatography (HPLC) method than the methods currently available. Efficient extraction procedures for biological samples are also valuable to save time, materials, and cost. We developed an HPLC method and compared several extraction methods for carotenoids, retinoids, and vitamin E in plasma and human breast milk. The method uses an Agilent 1100 system equipped with a Waters Spherisorb ODS2 column (3 9 125 mm 3 lm) and similar guard column (ThermoScientific ODS2 3 9 20 mm 3 lm). Mobile phase of 7:2:1 acetonitrile:dichloromethane: methanol was run at 0.5 mL min -1 , and run times were complete in approximately 8 min. This rapid method uses little solvent and provides excellent results in the analysis of these fat-soluble nutrients. Analyte measurements were repeatable using standards and plasma and were accurate compared to NIST certified and reference serum values. The validated HPLC method was applied to the analysis of plasma samples from a vitamin A intervention study.

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“…Since there is a differential antioxidant activity is different among antioxidants a combination could be more efficient. For example, Nishino et al [5] reported a high reducing cancer risk associated with a high combination of antioxidants. The mixture of different type of carotenoids may wider the range of biological effects and improves the efficiency in prevention or extending the expectancy.…”

Section: Letter To Editormentioning

confidence: 99%

Interest Trend on Antioxidants in Cancer Prevention and Therapy

Benmoussa¹

2017

J Nutr Food Sci

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Cancer prevention by carotenoids

Cited by 218 publications

References 6 publications

The colours of durum wheat: a review

The colours of durum wheat: a review

Rapid Isocratic HPLC Method and Sample Extraction Procedures for Measuring Carotenoid, Retinoid, and Tocopherol Concentrations in Human Blood and Breast Milk for Intervention Studies

Interest Trend on Antioxidants in Cancer Prevention and Therapy

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