Cancer Prevention by Natural Products Introduced into the Diet—Selected Cyclitols

Abstract

Cancer is now the second leading cause of death worldwide. It is estimated that every year, approximately 9.6 million people die of oncologic diseases. The most common origins of malignancy are the lungs, breasts, and colorectum. Even though in recent years, many new drugs and therapeutic options have been introduced, there are still no safe, effective chemopreventive agents. Cyclitols seem poised to improve this situation. There is a body of evidence that suggests that their supplementation can decrease the incidence of colorectal cancer, lower the risk of metastasis occurrence, lower the proliferation index, induce apoptosis in malignant cells, enhance natural killer (NK) cell activity, protect cells from free radical damage, and induce positive molecular changes, as well as reduce the side effects of anticancer treatments such as chemotherapy or surgery. Cyclitol supplementation appears to be both safe and well-tolerated. This review focuses on presenting, in a comprehensive way, the currently available knowledge regarding the use of cyclitols in the treatment of different malignancies, particularly in lung, breast, colorectal, and prostate cancers.

Novel Chemical and Biological Insights of Inositol Derivatives in Mediterranean Plants

“…Many of these were published in the period prior to the one considered in this review and for this reason they will not be taken into consideration. An overview of these studies has been excellently summarized by Wisniewsky and collaborators [ 98 ]. Studies with particular reference to colon cancer and colitis-induced cancer were collected and discussed by Vucenik and collaborators [ 99 ] and Weinberg and collaborators [ 100 ], respectively.…”

“…The anticancer activity of inositols has been defined as ‘broad spectrum’ thanks to their ability to modulate the whole cell cycle (progression, apoptosis, and differentiation) [ 101 ]. Furthermore, inositols seems able to play an important role improving the cure and decreasing side effects of cancer treatments [ 98 ]. Myo -inositol-trispyrophosphate is a non-cytotoxic molecule with tumour-reducing effects ascribed to its capability to promote vessel normalization, increases in oxygen partial pressure (pO 2 ) which counteracts hypoxia inside the tumour and inverts its effects.…”

Drug-loaded PEG-PLGA nanoparticles for cancer treatment

“…Tumor malignancies are the second leading cause of death worldwide and their treatment remains expensive and complex (Wiśniewski et al, 2020). Tumor drug therapies mainly include treatment with cytotoxic small molecules, drugs targeting genes or other molecules, as well as active substances of traditional Chinese medicine (TCM).…”

İnositolün Kanserin Önlenmesinde ve Tedavisindeki Etkinliği

“…Takviyenin yan etkileri nadir ve hafif olarak belirtilmiş olup, gastrointestinal semptomları kapsamaktadır(15). MI'nın güvenliği, genel olarak güvenli (Generally Recognized as Safe, GRAS) statüsüyle tanınan infant formülalarda kullanımı ile doğrulanmıştır(9).Literatüre göre oral MI tedavisi için tavsiye edilen doz 4000 mg/gün iken, CI için 1000 mg/gün'dür(16,17). Tarım ve Orman Bakanlığı'nın Takviye Edici Gıdalar Kısıtlı Maddeler Listesi'ne göre ise birlikte veya tek başına inositol, miyo insoitol, chiro inositol alımı, 4-10 yaş için maksimum 1000 mg/gün olarak, 11 yaş ve üzeri için maksimum 2000 mg/gün olarak belirlenmiştir(18).…”