Cancer Prevention Research in China

Yu, Siwang; Yang, Chung S.; Li, Junyao; You, Weichung; Chen, Jian Guo; Cao, Yang; Dong, Zigang; Qiao, You‐Lin

doi:10.1158/1940-6207.capr-14-0469

Cited by 31 publications

(16 citation statements)

References 96 publications

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“…The prevalence of smoking had declined since 1996, although it is still a main risk factor of cardiovascular diseases in Chinese population [37]. In addition, chronic respiratory diseases and neoplasms also played important roles in the increased LE, mainly benefited from successful management of air pollution such as industrial upgrading, environmental health policy implementation, surveillance [38] and the strategy of early diagnosis and treatment in cancer control based on the improved surveillance network [39,40]. However, since 2007, contributions of chronic respiratory diseases to LE for both sexes and contributions of neoplasms to LE for males decreased.…”

Section: Discussionmentioning

confidence: 99%

Patterns and changes in life expectancy in China, 1990-2016

Hai¹,

Qian²,

Dong³

et al. 2020

PLoS ONE

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Objective To achieve the goal of "healthy China 2030", reasonable health policies must be developed based on the changes of death spectrum. We aim to investigate the temporal patterns of life expectancy (LE) and age/cause-specific contributions from 1990 to 2016. Methods Joinpoint regression model was used with Arriaga's decomposition method. Results LE in China has reached to 76.3 years in 2016 with an increase of 9.44 years from 1990. From 1990 to 2002, a remarkable reduction in infant mortality accounted for an increase of 1.27 years (35.39%) to LE which mainly resulted from diarrhea, lower respiratory, and other common infectious diseases (1.00 years, 27.79%). After 2002, those aged 65+ years contributed most to increased LE and the most prominent causes included cardiovascular diseases (0.67 years, 23.36%), chronic respiratory diseases (0.54 years, 18.76%) and neoplasms (0.39 years, 13.44%). Moreover, the effects of transport injuries changed from negative to positive. After 2007, contributions of transport and unintentional injuries increased especially for males. And for females contributions of cardiovascular diseases sharply increased LE by 1.17 years (32.26%). Conclusion More attention should be paid to cardiovascular diseases, chronic respiratory diseases and neoplasms which were mainly attributed to the increase of LE, especially for males and elderly population.

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Section: Discussionmentioning

confidence: 99%

Patterns and changes in life expectancy in China, 1990-2016

Hai¹,

Qian²,

Dong³

et al. 2020

PLoS ONE

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“…Therefore, CRC has become a major public health issue. Although there has been great progress in diagnosis and therapy, the therapeutic effectiveness requires improvement, and the five-year survival rate is only approximately fifty percent 3 . The prognosis of CRC at an early stage is much better, and its five-year survival rate can reach ninety to one hundred percent 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

Identification of MST1 as a potential early detection biomarker for colorectal cancer through a proteomic approach

Zhai

et al. 2017

Sci Rep

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Colorectal cancer (CRC) is a common malignant neoplasm worldwide. It is important to identify new biomarkers for the early detection of CRC. In this study, magnetic beads and the Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) platform were used to analyse CRC and healthy control (HC) serum samples. The CRC diagnosis pattern was established to have a specificity of 94.7% and sensitivity of 92.3% in a blind test. The candidate biomarker serine/threonine kinase 4 (STK4, also known as MST1) was identified by Tandem mass spectrometry (MS/MS) and verified with western blotting and enzyme-linked immunosorbent assay (ELISA). The results indicated that there was a higher concentration of MST1 in HC subjects than stage I CRC patients for the early detection of CRC and a lower concentration in stage IV patients than in other CRC patients. The sensitivity and specificity of MST1 combined with carcinoembryonic antigen (CEA) and faecal occult blood test (FOBT) in diagnosis of colorectal cancer were 92.3% and 100%, respectively. Additionally, low MST1 expression was associated with the poor prognosis. These results illustrate that MST1 is a potential biomarker for early detection, prognosis and prediction of distant metastasis of CRC.

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“…The Global Cancer Report in 2014 indicates that approximately half of all new cancer cases occur in Asia, mostly in China, and that China’s new cancer cases ranked at the top of the list [ 1 ]. In fact, the incidence of cancer has been increasing for decades, and cancer is the leading cause of death in China [ 2 ]. Tremendous changes in the lifestyle and environment associated with economic development are important contributors to the increased cancer incidence [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Pretreatment glycemic control status is an independent prognostic factor for cervical cancer patients receiving neoadjuvant chemotherapy for locally advanced disease

Ning²,

Rao

et al. 2017

BMC Cancer

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BackgroundTo investigate whether poor glycemic control status has a negative impact on survival outcomes and tumor response to chemotherapy in patients receiving neoadjuvant chemotherapy (NACT) for locally advanced cervical cancer (LACC).MethodsA retrospective cohort study was conducted to examine LACC patients undergoing NACT and radical hysterectomy between 2002 and 2011. Patients were divided into three groups: patients without diabetes mellitus (DM), diabetic patients with good glycemic control, and diabetic patients with poor glycemic control. Hemoglobin A1c (HbA1c) levels were used to indicate glycemic control status. Recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS) were analyzed using log-rank tests and Cox proportional hazards models.ResultsIn total, 388 patients were included and had a median follow-up time of 39 months (range: 4–67 months). Diabetes mellitus (DM) was diagnosed in 89 (22.9%) patients, only 35 (39.3%) of whom had good glycemic control prior to NACT (HbA1c < 7.0%). In survival analysis, compared with patients with good glycemic control and patients without DM, patients with poor glycemic control (HbA1c ≥ 7.0%) exhibited decreased recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). In multivariate analysis, HbA1c ≥ 7.0% was identified as an independent predictor for decreased RFS (hazard ratio [HR] = 3.33, P < 0.0001), CSS (HR = 3.60, P < 0.0001) and OS (HR = 4.35, P < 0.0001). In the subgroup of diabetic patients, HbA1c ≥ 7.0% prior to NACT had an independent negative effect on RFS (HR = 2.18, P = 0.044) and OS (HR = 2.29, P = 0.012). When examined as a continuous variable, the HbA1c level was independently associated with decreased RFS (HR = 1.39, P = 0.002), CSS (HR = 1.28, P = 0.021) and OS (HR = 1.27, P = 0.004). Both good (odds ratio [OR] = 0.06, P < 0.0001) and poor glycemic control (OR = 0.04, P < 0.0001) were independently associated with a decreased likelihood of complete response following NACT.ConclusionsPoor glycemic control is an independent predictor of survival and tumor response to chemotherapy for patients receiving NACT for LACC.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-017-3510-3) contains supplementary material, which is available to authorized users.

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Cancer Prevention Research in China

Abstract: Although cancer incidence and mortality rates in the United

Cited by 31 publications

References 96 publications

Patterns and changes in life expectancy in China, 1990-2016

Patterns and changes in life expectancy in China, 1990-2016

Identification of MST1 as a potential early detection biomarker for colorectal cancer through a proteomic approach

Pretreatment glycemic control status is an independent prognostic factor for cervical cancer patients receiving neoadjuvant chemotherapy for locally advanced disease

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