Cancer Procoagulant Stimulates Platelet Adhesion

Olas, Beata; Mielicki, Wojciech P.; Wachowicz, Barbara; Krajewski, Tadeusz

doi:10.1016/s0049-3848(98)00214-x

Cited by 31 publications

(18 citation statements)

References 17 publications

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“…Thus, the indirect activation of platelets by both TF and CP via thrombin generation was expected. However, Olas et al [76, 77]demonstrated that CP can induce direct, dose-dependent platelet activation by a mechanism that appears to be similar to that of thrombin. When CP and thrombin are added to platelets simultaneously, the stimulation is not additive, but rather reflects the mean of the stimulation of each agonist alone.…”

Section: Cancer Procoagulantmentioning

confidence: 99%

Update on Tumor Cell Procoagulant Factors

Gale

Gordon²

2001

Acta Haematol

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Tumor cells produce tissue factor, cancer procoagulant, plasminogen activators and other factors that interact with the coagulation system, the fibrinolytic system and vascular or blood cells such that they can upset the normal homeostasis and balance between activation and inhibition of the coagulation and fibrinolytic systems. These activities play a role in tumor cell growth and metastasis, vascular wall function, and hemostasis. Proteases and their inhibitors are intimately involved in all aspects of the hemostatic, cell proliferation and cellular signalling systems. This review provides a brief examination of recent observations in this complex interaction of cellular and hemostatic factors.

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Section: Cancer Procoagulantmentioning

confidence: 99%

Update on Tumor Cell Procoagulant Factors

Gale

Gordon²

2001

Acta Haematol

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“…Although the proangiogenic effects of platelets have been documented in vitro and in tumors (36,37), little is known about platelets' precise role in regulating angiogenesis in vivo. To address this question, we examined the role of platelets in two different in vivo assays of angiogenesis in four animal models.…”

mentioning

confidence: 99%

Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage

Kisucka

Butterfield

Duda

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

326

241

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Platelets contain both pro-and antiangiogenic factors, but their regulatory role in angiogenesis is poorly understood. Although previous studies showed that platelets stimulate angiogenesis in vitro, the role of platelets in angiogenesis in vivo is largely uncharacterized. To address this topic, we used two in vivo approaches, the cornea micropocket assay and the Matrigel model, in four animal models: thrombocytopenic, Lyst bg (platelet storage pool deficiency), glycoprotein (GP) Ib␣͞IL4R transgenic (lacking extracellular GPIb␣, the receptor for von Willebrand factor as well as other adhesive and procoagulant proteins), and Fc␥R ؊/؊ (lacking functional GPVI, the collagen receptor) mice. Adult mice were rendered thrombocytopenic by i.p. administration of an antiplatelet antibody. The number of growing vessels in the thrombocytopenic mice was lower in the cornea assay, and they showed significantly increased appearance of hemorrhage compared with mice treated with control IgG. The thrombocytopenic mice also showed more protein leakage and developed hematomas in the Matrigel model. GPIb␣͞IL4R transgenic mice presented increased hemorrhage in both assays, but it was less severe than in the platelet-depleted mice. Fc␥R ؊/؊ and Lyst bg mice showed no defect in experimental angiogenesis. Intravital microscopy revealed a >3-fold increase in platelet adhesion to angiogenic vessels of Matrigel compared with mature quiescent skin vessels. Our results suggest that the presence of platelets not only stimulates angiogenic vessel growth but also plays a critical role in preventing hemorrhage from the angiogenic vessels. The adhesion function of platelets, as mediated by GPIb␣, significantly contributes to the process. thrombocytopenic mice ͉ blood vessel ͉ ␣-granule ͉ cornea ͉ collagen receptor

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“…Increased platelet count in patients with malignancies may be explained by the link between platelets and angiogenesis (Pinedo et al, 1998;Olas et al, 1999;Banks et al, 1998). Certain types of malignancy can activate platelets in vitro through direct contact, release of ADP, production of thromboxane A2 or cancer procoagulant, generation of thrombin, or activation of the tumor-associated proteinases (Olas et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Certain types of malignancy can activate platelets in vitro through direct contact, release of ADP, production of thromboxane A2 or cancer procoagulant, generation of thrombin, or activation of the tumor-associated proteinases (Olas et al, 1999). In the presence of vascular endothelial growth factor (VEGF), which is a platelet-derived cytokine, endothelial cells promote platelet aggregation (Verheul et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume and mean platelet volume/platelet count ratio as markers for hepatocellular carcinoma in patients with chronic hepatitis C virus related cirrhosis

Metwaly¹,

Sameea²,

El-Azab³

et al. 2016

J. Cancer Res. Exp. Oncol.

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Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. The lack of efficient and precise HCC biomarkers prevents early detection resulting in a poor prognosis. Recently, mean platelet volume (MPV) and MPV/platelet count (PC) ratio have been proposed as potential markers of HCC. This study was carried out to verify MPV and MPV/PC ratio in diagnosis of HCC in Egyptian patients with chronic hepatitis C related liver cirrhosis. One hundred and fifty chronic hepatitis C (CHC) patients with chronic hepatitis, cirrhosis or HCC were enrolled in the study. The levels of alphe feto protein (AFP), MPV and MPV/PC ratio were determined compared to 50 healthy persons. MPV and MPV/CP ratio were higher in patients with cirrhosis and those with HCC. The cut off level for MPV for detection of HCC was 10.1 fl, with sensitivity of 70% and specificity of 57%. At a cut off level of 0.82, the sensitivity of MPV/CP ratio was 79.6% and specificity was 72.7%. AFP showed sensitivity 80% and specificity 82% at cut-off level of 16.9 ng/dl. MPV and MPV/PC ratio are less sensitive and specific than AFP as markers for HCC; they may be used only in association with other markers to improve sensitivity of tumor detection.

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Cancer Procoagulant Stimulates Platelet Adhesion

Cited by 31 publications

References 17 publications

Update on Tumor Cell Procoagulant Factors

Update on Tumor Cell Procoagulant Factors

Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage

Mean platelet volume and mean platelet volume/platelet count ratio as markers for hepatocellular carcinoma in patients with chronic hepatitis C virus related cirrhosis

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