Cancer pulmonaire

Cherfils‐Vicini, Julien; Damotte, Diane; Fridman, Wolf-Herman; Sautès-Fridman, Catheriné; Cremer, Isabelle

doi:10.1051/medsci/2010264435

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…In various cancers, TLR 5 and 7 have been suggested to have either a prognostic role in in vivo studies [17][18][19][20][21]27], or a functional role in in vitro studies [31][32][33][34][35][36]. Kauppila et al suggested that high TLR 5 expression is associated with high rate of mortality and recurrences in oral mobile tongue SCC [17], and Ni et al suggested that high expression of TLR 7 could improve survival in oral SCC [21].…”

Section: Discussionmentioning

confidence: 99%

“…Table 3 TLR 5, 7, and 9 expression and 5-year locoregional and distant RFS Log-rank test was used in the statistical analysis. Death with disease and death with no evidence of disease were censored TLR 5 TLR 7 TLR 9 0 (%) 1 (%) 2 (%) 3 (%) P 1 (%) 2 (%) 3 (%) P 0 (%) 1 (%) 2 (%) 3 (%) P Stimulation of TLR 7 promotes cancer-cell survival and chemoresistance in adenocarcinoma and SCC of the lung [33,34]. In oral cancer, however, activation of TLR with imiquimod, a pharmaceutical product used clinically for basal cell carcinoma, reduces tumor growth [35] and in breast cancer enhances radiosensitivity [36].…”

Section: Discussionmentioning

confidence: 99%

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Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients

Jouhi

Mohamed

Mäkitie

et al. 2017

Cancer Immunol Immunother

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A large subset of oropharyngeal squamous cell carcinomas (OPSCCs) is associated with HPV infection and has better outcome than non-viral-related tumors. Various malignancies also carry a role for TLRs, key activators of inflammation and innate immunity. We examined the expression of TLRs in OPSCC, and their association with HPV status and treatment outcome. TLR 5, 7, 9, and p16 were studied by immunohistochemistry and HPV status was detected with in situ hybridization in 202 tumors of consecutively treated OPSCC patients using tissue microarray method. The relations between TLR expression and HPV status, p16 expression, clinicopathological factors, and survival were analyzed. TLR 5, 7, and 9 expression patterns differed between HPV-positive and -negative tumors, and they were statistically significantly associated with history of smoking, heavy drinking, tumor site, grade, size (T), metastasis (N), and stage. Moreover, in HPV-positive tumors the expression of TLR 5 and 7 correlated with tumor recurrence. After adjustment, among HPV-positive OPSCC patients, high TLR 5 and low TLR 7 expression were associated with poor disease-specific survival. Our results indicate that TLR 5 and 7 may have a role in the prognostication of HPV-positive OPSCC, however, further studies are needed to clarify the comprehensive role of these TLRs in OPSCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients

Jouhi

Mohamed

Mäkitie

et al. 2017

Cancer Immunol Immunother

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Expression of toll-like receptors in HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma—an in vivo and in vitro study

et al. 2015

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The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased over the past decades in many western countries. This trend is mainly attributed to the human papillomavirus (HPV). Cancer-related actions of immunological defense systems are being intensively researched. Human toll-like receptors (TLRs) are a family of pattern recognition receptors that participate in the immunological defense against pathogens, but their actions are also linked to cancer. The expression of TLRs in cervical epithelium alters both during the clearance of HPV infection and the HPV-induced neoplasia, but the expression of TLRs has not been studied in OPSCC. Thirty-five paraffin-embedded, formalin-fixed, squamous cell carcinoma tissue specimens were analyzed for TLRs 2, 3, 4, 5, 7, and 9 and HPV and p16 statuses. The TLR 9 expression was lower in HPV-positive tumors compared with HPV-negative tumors. TLR 7 was expressed in all cancer specimens, but elevated expression was evident in HPV and/or p16-positive tumors. The majority of p16-positive tumors did not express TLR 5, whereas its expression was stronger in p16-negative tumors. The results of in vitro analysis of five human OPSCC cell lines and one human oral tongue squamous cell carcinoma cell line agree with the in vivo trends: low levels of TLR 5 and high levels of TLR 7 in p16-positive OPSCC. Overall, TLR 7 and 9 expression patterns are demonstrated here to relate to the HPV status in vivo and TLR 5 and 7 expression patterns to the p16 status in vivo and in vitro.

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Cationic lipid-assisted nanoparticles for simultaneous delivery of CD47 siRNA and R848 to promote antitumor immune responses

Chen

et al. 2023

Front. Pharmacol.

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Cancer pulmonaire

Cited by 4 publications

References 11 publications

Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients

Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients

Expression of toll-like receptors in HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma—an in vivo and in vitro study

Cationic lipid-assisted nanoparticles for simultaneous delivery of CD47 siRNA and R848 to promote antitumor immune responses

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