Cancer-Related Fatigue: Causes and Current Treatment Options

Thong, Melissa S. Y.; Noorden, C. J. F. Van; Steindorf, Karen; Arndt, Volker

doi:10.1007/s11864-020-0707-5

Cited by 254 publications

(289 citation statements)

References 134 publications

(198 reference statements)

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“…Cancer-related fatigue, also known as cancer fatigue, is a highly prevalent long-term side effect among breast cancer survivors (7,8). This complex and multidimensional condition is clinically characterized by a persistent sense of physical, emotional, and/or cognitive stiffness, resulting in a substantial impairment of health-related quality of life (7,9). The etiology of breast cancer fatigue (BCF) is poorly understood and probably related to mitochondrial dysfunction, inflammation, and increased reactive oxygen species production (8,10,11).…”

Section: Introductionmentioning

confidence: 99%

“…However, the wide subjectivity of BCF hinders further research to explain its pathogenesis. Several risk factors have been identified so far, including low socioeconomic status, sleep disturbance, emotional stress, anxiety, physical inactivity, high body mass index (BMI), radical surgery, chemotherapy, and radiotherapy (8,9). According to the American Society of Clinical Oncology (ASCO) and the National Comprehensive Cancer Network (NCCN) guidelines, specific screening programs for BCF should be performed (7,12).…”

Section: Introductionmentioning

confidence: 99%

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Impact of Rehabilitation on Breast Cancer Related Fatigue: A Pilot Study

et al. 2020

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Breast cancer fatigue (BCF) is a complex and multidimensional condition characterized by a persistent sense of physical and/or mental stiffness, resulting in a substantial impairment of health-related quality of life in breast cancer survivors. Aim of this prospective cohort study was to evaluate the feasibility and the effectiveness of a 4-week rehabilitation protocol on BCF, muscle mass, strength, physical performance, and quality of life in breast cancer (BC) survivors. We recruited adult BC women with a diagnosis of BCF, according to the International Classification of Diseases 10 criteria, referred to the Outpatient Service for Oncological Rehabilitation of a University Hospital. All participants performed a specific physical exercise rehabilitative protocol consisting of 60-min sessions repeated 2 times/week for 4 weeks. All outcomes were evaluated at the baseline (T0), at the end of the 4-week rehabilitation treatment (T1), and at 2 months follow up (T2). The primary outcome measure was the Brief Fatigue Inventory (BFI); secondary outcomes included: Fat-Free Mass and Fat Mass, assessed by Bioelectrical Impedance Analysis (BIA); Hand Grip Strength Test (HGS); Short Physical Performance Battery (SPPB); 10-meter walking test (10 MWT); 6-min walking test (6 MWT); European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). Thirty-six women (mean age: 55.17 ± 7.76 years) were enrolled in the study. Significant reduction of BCF was observed both after the 4-week rehabilitation treatment (T1) (BFI: 5.4 ± 1.6 vs. 4.2 ± 1.7; p = 0.004) and at the follow-up visit (T2) (BFI: 5.4 ± 1.6 vs. 4.4 ± 1.6; p = 0.004). Moreover, significant differences (p < 0.001) HGS, SPPB, 10 MWT, 6 MWT, and EORTC QLQ-C30 were found at T1, while at T2 all the outcome measures were significantly different (p < 0.05) from the baseline. The rehabilitation protocol seemed to be feasible, safe, and effective in reducing BCF, improving muscle mass and function, and improving HRQoL in a cohort of BC survivors. The results of this study could improve awareness of this underestimated disease, suggesting the definition of a specific therapeutic exercise protocol to reduce BCF.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of Rehabilitation on Breast Cancer Related Fatigue: A Pilot Study

et al. 2020

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“…It has been reported that BCRL involves more than 25% of breast cancer survivors, [3,4] while axillary web syndrome (AWS) after axillary lymph node dissection affects in 6 to 85.4% [5,6]. Cancer-related fatigue is a common disabling conditions in breast cancer survivors [7]. It has been estimated that approximately one-third of cancer survivors have clinically significant fatigue up to 6 years following treatment [8].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal changes in sports activity from pre-diagnosis to first five years post-diagnosis: a prospective Chinese breast cancer cohort study

Lei

Kwok³

et al. 2020

BMC Cancer

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Background To compare change in level of physical activity between pre-and post- diagnosis of breast cancer in Chinese women. Methods Based on an on-going prospective study consisting of a sample of Chinese women with breast cancer, a validated modified Chinese Baecke questionnaire was used to measure physical activity at baseline (12 months before cancer diagnosis), 18-, 36- and 60-months after diagnosis (over the previous 12 months before each interview). Results In our cohort of 1462 Chinese women with a mean age of 52 years, the mean level of physical activity at post-diagnosis was 9.6 metabolic equivalent of task (MET)-hours/week, which was significantly higher than that at pre-diagnosis with mean level of 5.9 MET-hours/week (P < 0.001). The mean levels of physical activity at 18-, 36- and 60-months follow-up were 9.9, 9.8 and 9.3 MET-hours/week, respectively. There was no significant difference between any two of the three follow-ups at post-diagnosis. The proportions of participant who met World Cancer Research Fund/ American Institute for Cancer Research (WCRF/AICR) recommendation before and after cancer diagnosis were both low, being 20.7 and 35.1%, respectively. Compared to pre-diagnosis, most of the patients improved or had no change on level of physical activity at post-diagnosis, with the respective proportion being 48.2 and 43.8%. Conclusions Adherence to current lifestyle recommendation for cancer survivors, Chinese women with breast cancer significantly increased level of physical activity level after cancer diagnosis, and such improvement was sustained to 5 years post-diagnosis. The proportion of patients who met the exercise recommendation for cancer survivors was still low. Encouraging patients on the importance of durable high level of physical activity in breast cancer survivorship is warranted.

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“…[5,6] Cancer-related fatigue is a common disabling conditions in breast cancer survivors. [7] It has been estimated that approximately onethird of cancer survivors have clinically signi cant fatigue up to 6 years following treatment. [8] Breast cancer survivorship care has aroused increasing attention in recent years, and the management of the above-mentioned complications are topics of concern in the rehabilitation eld.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal changes in sports activity from pre-diagnosis to first five years post-diagnosis: a prospective Chinese breast cancer cohort study

Lei

Kwok

et al. 2020

Preprint

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Background: To compare change in level of physical activity between pre-and post- diagnosis of breast cancer in Chinese women.Methods: Based on an on-going prospective study consisting of a sample of Chinese women with breast cancer, a validated modified Chinese Baecke questionnaire was used to measure physical activity at baseline (12 months before cancer diagnosis), 18-, 36- and 60-months after diagnosis (over the previous 12 months before each interview). Results: In our cohort of 1462 Chinese women with a mean age of 52 years, the mean level of physical activity at post-diagnosis was 9.6 metabolic equivalent of task (MET)-hours/week, which was significantly higher than that at pre-diagnosis with mean level of 5.9 MET-hours/week (P < 0.001). The mean levels of physical activity at 18-, 36- and 60-months follow-up were 9.9, 9.8 and 9.3 MET-hours/week, respectively. There was no significant difference between any two of the three follow-ups at post-diagnosis. The proportions of participant who met World Cancer Research Fund/ American Institute for Cancer Research (WCRF/AICR) recommendation before and after cancer diagnosis were both low, being 20.7% and 35.1%, respectively. Compared to pre-diagnosis, most of the patients improved or had no change on level of physical activity at post-diagnosis, with the respective proportion being 48.2% and 43.8%. Conclusions: Adherence to current lifestyle recommendation for cancer survivors, Chinese women with breast cancer significantly increased level of physical activity level after cancer diagnosis, and such improvement was sustained to five years post-diagnosis. The proportion of patients who met the exercise recommendation for cancer survivors was still low. Encouraging patients on the importance of durable high level of physical activity in breast cancer survivorship is warranted.

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Cancer-Related Fatigue: Causes and Current Treatment Options

Cited by 254 publications

References 134 publications

Impact of Rehabilitation on Breast Cancer Related Fatigue: A Pilot Study

Impact of Rehabilitation on Breast Cancer Related Fatigue: A Pilot Study

Longitudinal changes in sports activity from pre-diagnosis to first five years post-diagnosis: a prospective Chinese breast cancer cohort study

Longitudinal changes in sports activity from pre-diagnosis to first five years post-diagnosis: a prospective Chinese breast cancer cohort study

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