Cancer-related Fatigue in Breast Cancer Survivors: A Review

Ruiz-Casado, Ana; Álvarez‐Bustos, Alejandro; Pedro, C.; Méndez-Otero, Marta; Romero-Elías, María

doi:10.1016/j.clbc.2020.07.011

Cited by 115 publications

(103 citation statements)

References 120 publications

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“…Physical condition is composed of a) body composition, estimated by BMI, waist and hip perimeter; b) muscular strength estimated through the test sit to stand and handgrip strength; c) cardiorespiratory tness estimated through the MWT. BMI has consistently been associated with CRF [16,26]. Weight, BMI and hip perimeter were predictors of fatigue in this cohort.…”

Section: Discussionmentioning

confidence: 52%

“…In line with other studies, the longer the time elapsed from the diagnosis the less the fatigue reported by cancer survivors. Contrary to the expected, the role of chemotherapy and radiotherapy is controversial [15,26]. In this cohort, having been exposed to chemotherapy and speci cally to anthracyclines or radiotherapy was not associated with fatigue.…”

Section: Discussionmentioning

confidence: 63%

“…Some correlates could be interpreted as potential cause of fatigue such as weight or trastuzumab, whereas others seem to be symptoms that co-ocurred such as pain or dyspnea. It is very well known the presentation of fatigue as symptom cluster [26]. But a role of these symptoms triggering or maintaining fatigue cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

“…The impact of cancer diagnosis and treatment on the development of fatigue is beyond doubt since fatigue is consistently higher among BC survivors than among their counterparts [26,31]. However, the mechanisms which mediate the appearance of fatigue have not been completely elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…Fatigue is multifactorial and can be in uenced by social [7,31], medical [12], psychosocial [3], behavioural [32] and biological factors. In terms of socio-demographic factors, younger [26], unmarried patients [7,31] and those with a lower household income [31] have been reported to have a higher risk of reporting fatigue. Only age was signi cant among socio-demographic factors in this cohort.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Correlates of Cancer-related Fatigue in Breast Cancer Survivors

Bustos¹,

Pedro

Elías

et al. 2021

Preprint

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Purpose To identify potential correlates of CRF after curative breast cancer (BC) treatment. The hypothesis was that fatigue would be more severe among women treated with cardiotoxic drugs, with poor physical condition and those who exercised less.Methods Prospective observational cross-sectional design. Fatigue was evaluated through Perform Questionnaire (multi-item, multi-dimensional). Patient-reported assessments and objective information regarding clinical data, physical activity (PA) and physical condition were analysed as potential correlates of CRF.Results 180 women who remained free of disease were recruited. Prevalence of fatigue interfering with quality of life was 43%. Weight, BMI, treatment with trastuzumab and time spent walking one mile were positively associated with fatigue. Age, time from diagnosis, self-reported walking time, basal and recovery heart rate were negatively associated. Previous chemo, radio or hormonal therapy, objectively assessed weekly PA, cardio-respiratory condition, muscular strength and adherence to Mediterranean diet were not associated with CRF. However, an interesting unexpected negative association with nut intake was found.Conclusions CRF is a prevalent problem after BC treatment. Objectively assessed PA, cardiorespiratory fitness and muscular strength did not predict CRF. The association of CRF with trastuzumab and low intake of nuts should be confirmed in further studies. A deeper insight in heart rate variability is warranted. Future research should include longitudinal studies and determination of biomarkers. Implications for Cancer Survivors BC survivors, especially younger and overweight women, should be informed about fatigue as a potential persistent symptom through all stages of the cancer trajectory and into survivorship. They also should be routinely screened for CRF.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prevalence and Correlates of Cancer-related Fatigue in Breast Cancer Survivors

Bustos¹,

Pedro

Elías

et al. 2021

Preprint

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Mediating effects of rumination on insomnia in cancer survivors: Influences of cancer‐related fatigue, fear of recurrence, and psychological distress

Amani,

Mazaheri,

Malekzadeh Moghani

et al. 2024

Cancer Medicine

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BackgroundWhile advancements in cancer treatments have improved survival rates, they also lead to adverse effects such as insomnia, which significantly impacts survivors' sleep quality.ObjectiveThis study explores the influence of cancer‐related fatigue (CRF), Fear of Cancer Recurrence (FCR), and psychological distress, with rumination serving as a mediating factor, on the insomnia experienced by cancer survivors.MethodsThe study involved 220 cancer survivors attending Shohada‐e‐Tajrish Hospital's oncology center in Tehran, Iran. Participants were selected through convenience sampling and completed several questionnaires: the Insomnia Severity Index, Fear of Cancer Recurrence Inventory, Cancer Fatigue Scale, Kessler Psychological Distress Scale, and Rumination Response Scale.ResultsThe results showed that the tested model had a good fit, and the correlation matrix demonstrated significant positive correlations between CRF (0.46), FCR (0.15), psychological distress (0.55), and rumination (0.42) with insomnia in cancer survivors (p < 0.05). Notably, CRF (B = 0.356, p < 0.001) and psychological distress (B = 0.339, p < 0.001) affect insomnia both directly and indirectly through mediation by rumination, while the impact of FCR on insomnia was indirectly significant (B = 0.73, p < 0.05).ConclusionThe findings suggest that interventions focused on managing rumination could be potential targets to alleviate insomnia and improve the sleep quality of cancer survivors.

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Network Analyses Applied to the Dimensions of Cancer‐Related Fatigue in Women With Breast Cancer

Baussard,

Ernst,

Diep

et al. 2024

Cancer Medicine

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BackgroundUnderstanding cancer symptom cluster through network analyses is a new approach in oncology, revealing interconnected and influential relationships among reported symptoms. We aimed to assess these relationships using network analysis in posttreatment breast cancer patients, focusing on the five dimensions of cancer‐related fatigue (CRF), and on other common difficulties encountered by oncological patients (i.e., pain, anxiety, depression, sleep difficulties, cognitive impairments, and emotion regulation and mental adaptation difficulties).MethodThis study involved a complementary analysis of data from two interventional studies. Participants completed questionnaires before and after the intervention, with baseline scores being used in this article. Partial correlation network analysis modeled the relationships between symptoms in five distinct networks, each of them including one specific dimension of CRF. The core symptom in each network was identified based on the highest centrality indices.ResultsDepression emerged as the core symptom in all networks, strongly associated with all fatigue dimensions (partial correlations ranging from 0.183 to 0.269) except mental fatigue. These findings indicate robust connections between symptoms, as variations in depression scores directly or indirectly influence fatigue and other symptoms within the cluster.ConclusionOur results support the multidimensional aspect of CRF, and its links with other common symptoms. To effectively reduce patient CRF, interventions should address not only fatigue but also the closely related symptoms from the cluster, such as depression, given its centrality in the cluster.Trial Registration: ClinicalTrials.gov (NCT03144154 and NCT04873661). Retrospectively registered on May 1, 2017 and April 29, 2021, respectively.

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Cancer-related Fatigue in Breast Cancer Survivors: A Review

Cited by 115 publications

References 120 publications

Prevalence and Correlates of Cancer-related Fatigue in Breast Cancer Survivors

Prevalence and Correlates of Cancer-related Fatigue in Breast Cancer Survivors

Mediating effects of rumination on insomnia in cancer survivors: Influences of cancer‐related fatigue, fear of recurrence, and psychological distress

Network Analyses Applied to the Dimensions of Cancer‐Related Fatigue in Women With Breast Cancer

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