Cancer relevance of signal recognition particle RNA and other non-coding RNAs in extracellular vesicles

Rappa, Germana; Alice, Alice; Santos, Mark F.; Alessandro, Riccardo; Lorico, Aurelio

doi:10.21037/tcr.2017.09.38

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…[ 49 ] reported the prevalence of non-coding RNA species distinct from miRNAs, in particular signal recognition particles (SRP) RNA in stromal cell-derived EVs released during co-culture with breast cancer cells. As we discussed in a recent Commentary [ 50 ], this is surprising given the general consensus in the EV field on the prevalence of coding RNA and miRNA in EVs. In fact, the main EV data repository, “Vesiclopedia” ( ), contains ~28,000 entries for mRNAs and ~5,000 entries for miRNAs, but no entries for other non-coding RNAs.…”

Section: Potential Advantages Of Evs For Liquid Biopsymentioning

confidence: 99%

Extracellular Vesicles from Thyroid Carcinoma: The New Frontier of Liquid Biopsy

Rappa

Puglisi²,

Santos

et al. 2019

IJMS

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The diagnostic approach to thyroid cancer is one of the most challenging issues in oncology of the endocrine system because of its high incidence (3.8% of all new cancer cases in the US) and the difficulty to distinguish benign from malignant non-functional thyroid nodules and establish the cervical lymph node involvement during staging. Routine diagnosis of thyroid nodules usually relies on a fine-needle aspirate biopsy, which is invasive and often inaccurate. Therefore, there is an urgent need to identify novel, accurate, and non-invasive diagnostic procedures. Liquid biopsy, as a non-invasive approach for the detection of diagnostic biomarkers for early tumor diagnosis, prognosis, and disease monitoring, may be of particular benefit in this context. Extracellular vesicles (EVs) are a consistent source of tumor-derived RNA due to their prevalence in circulating bodily fluids, the well-established isolation protocols, and the fact that RNA in phospholipid bilayer-enclosed vesicles is protected from blood-borne RNases. Recent results in other types of cancer, including our recent study on plasma EVs from glioblastoma patients suggest that information derived from analysis of EVs from peripheral blood plasma can be integrated in the routine diagnostic tumor approach. In this review, we will examine the diagnostic and prognostic potential of liquid biopsy to detect tumor-derived nucleic acids in circulating EVs from patients with thyroid carcinoma.

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Section: Potential Advantages Of Evs For Liquid Biopsymentioning

confidence: 99%