Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population‐based cohort study in Sweden

Shu, Xiaochen; Ji, Jianguang; Li, Xinjun; Sundquist, Jan; Sundquist, Kristina; Hemminki, Kari

doi:10.1111/j.1464-5491.2010.03011.x

Cited by 105 publications

(100 citation statements)

References 31 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some studies included type 1 and type 2 diabetes, which would lead to an attenuation of the risk estimates if only type 2 diabetes is a risk factor for kidney cancer. In fact, a population-based cohort study in Sweden found no excess risk of kidney cancer in hospitalised type 1 diabetes patients [32]. Moreover, because total kidney cancer was assessed in most studies, the overall association would be attenuated if diabetes were a risk factor for renal cell (parenchyma) or renal pelvis cancer only.…”

Section: Discussionmentioning

confidence: 98%

Diabetes mellitus and incidence of kidney cancer: a meta-analysis of cohort studies

2011

View full text Add to dashboard Cite

Aims/hypothesis Diabetes is associated with increased risk of cancer at several sites, but its association with cancer of the kidney is unclear. We performed a systematic review with meta-analysis to examine the association between diabetes and incidence of kidney cancer. Methods Pertinent studies were identified by searching PubMed (from January 1966 to December 2010) and reviewing the reference lists of relevant articles. We included cohort studies reporting RR estimates and 95% CI (or data to calculate them) of the association between diabetes and kidney cancer incidence. Summary RRs were calculated using a random-effects model. Results Nine cohort studies met the inclusion criteria. Analysis of all studies showed that compared with individuals without diabetes, patients with diabetes had a statistically significant increased risk of kidney cancer (RR 1.42, 95% CI 1.06-1.91). There was heterogeneity among studies (p<0.001 for heterogeneity). The association was stronger in women (RR 1.70, 95% CI 1.47-1.97) than in men (RR 1.26, 95% CI 1.06-1.49). When restricting the analysis to studies that had adjusted for body mass index (n=3) or cigarette smoking (n=3), the RRs were 1.12 (95% CI 0.99-1.27) and 1.29 (95% CI 1.05-1.58), respectively. Conclusions/interpretation This meta-analysis indicates a positive association between diabetes and risk of kidney cancer. Future research should attempt to establish whether this association is causal.

show abstract

Section: Discussionmentioning

confidence: 98%

Diabetes mellitus and incidence of kidney cancer: a meta-analysis of cohort studies

2011

View full text Add to dashboard Cite

show abstract

“…However, all three studies failed to meet the inclusion criteria with two studies failing to include an internal control group (Zendehel et al 2003, Shu et al 2010 while one study assumed a diagnosis of type 1 diabetes mellitus in all patients aged under 35 years without confirmation (Baron et al 2001). Interestingly, the studies were homogenous in their finding of a protective risk point estimate despite none of the studies reaching statistical significance.…”

Section: Type 1 Diabetes Mellitusmentioning

confidence: 89%

“…1). Eleven studies were excluded for failing to include an internal control group (De Waard & Baanders Van Halewijn 1974, Ragozzino et al 1982, Adami et al 1991, Hjalgrim et al 1997, Weiderpass et al 1997, Wideroff et al 1997, Kath et al 2000, Zendehel et al 2003, Swerdlow et al 2005, Shu et al 2010, three studies were excluded for investigating mortality rather than incidence (Coughlin et al 2004, Siegelmann-Danieli et al 2006, Tseng et al 2009), one study was excluded for using benign breast disease as a comparator (Muck et al 1975) and the final study was excluded for investigating the effect of glycaemic control on BC incidence (Stefansdottir et al 2011). The remaining 43 studies were included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Diabetes increases the risk of breast cancer: a meta-analysis

Hardefeldt

Edirimanne

Eslick

2012

Endocrine-Related Cancer

134

View full text Add to dashboard Cite

The aim of this meta-analysis was to collate and analyse all primary observational studies investigating the risk of breast cancer (BC) associated with diabetes. In addition, we aimed to complete subgroup analyses by both type of diabetes and gender of study participants to further clarify the origin of any such association between the two. Studies were obtained from a database search of MEDLINE, EMBASE, PubMed, Current Contents Connect and Google Scholar with additional cross-checking of reference lists. Collated data were assessed for heterogeneity and a pooled odds ratio (OR) calculated. Forty-three studies were included in the meta-analysis with 40 studies investigating BC in women and six studies investigating BC in men. Overall, we found a significantly increased risk of BC associated with diabetes in women (OR 1.20, 95% confidence interval (CI) 1.13-1.29). After subgroup analysis by type of diabetes, the association was unchanged with type 2 diabetes (OR 1.22, 95% CI 1.07-1.40) and nullified with gestational diabetes (OR 1.06, 95% CI 0.79-1.40). There were insufficient studies to calculate a pooled OR of the risk of BC associated with type 1 diabetes. There was an increased risk of BC in males with diabetes mellitus; however, the results did not reach statistical significance (OR 1.29, 95% CI 0.99-1.67). In conclusion, diabetes increases the risk of BC in women. This association is confirmed in women with type 2 diabetes and supports the hypothesis that diabetes is an independent risk factor for BC.

show abstract

“…Analyses of type 1 diabetes cohorts, compared with the general population, suggest increased risks in some cancers (for example, ovarian cancer in a UK series [24]), but these are not consistent across all studies [24][25][26][27]. Notably, there does not appear to be associations between type 1 diabetes and the cancers linked with type 2 diabetes-i.e.…”

Section: Epidemiology Of Diabetes and Cancer Incidencementioning

confidence: 95%

Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence

et al. 2012

View full text Add to dashboard Cite

Substantial evidence suggests that people with type 2 diabetes have an increased risk of developing several types of cancers. These associations may be due to a number of direct and indirect mechanisms. Observational studies of these associations, including the potential role for glucoselowering therapy, are being increasingly reported, but face a number of methodological challenges. This paper is the first of two review papers addressing methodological aspects underpinning the interpretations of links between diabetes and cancer, and suggests potential approaches to study designs to be considered in observational studies. This paper reviews factors related to cancer incidence in the diabetic population; the second paper relates to studies of cancer mortality.

show abstract

Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population‐based cohort study in Sweden

Abstract: By quantifying the variations of overall and site-specific cancer risks after T1DM, the current study provides novel associations between T1DM and subsequent cancers, the mechanisms of which remain to be established.

Cited by 105 publications

References 31 publications

Diabetes mellitus and incidence of kidney cancer: a meta-analysis of cohort studies

Diabetes mellitus and incidence of kidney cancer: a meta-analysis of cohort studies

Diabetes increases the risk of breast cancer: a meta-analysis

Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence

Contact Info

Product

Resources

About