Cancer risk estimates from radiation therapy for heterotopic ossification prophylaxis after total hip arthroplasty

Abstract

The risk for cancer induction from radiation therapy for HO prophylaxis after total hip arthroplasty varies considerably by the treatment parameters, organ site in respect to treatment volume and patient's gender and age. The presented risk estimates may be useful in the follow-up studies of irradiated patients.

Identifying the Cellular Mechanisms Leading to Heterotopic Ossification

“…the excision of ectopic bone) [18]. However, radiotherapy is by no means ideal since it carries a number of potential risks such as malignancy, genetic mutations, and gonadal effects [19,20]. Bisphosphonate use remains controversial after a Cochrane review [21] failed to find conclusive evidence of efficacy.…”

Total Hip Arthroplasty for Patients Who Have Ankylosing Spondylitis: Is Postoperative Irradiation Required for Prophylaxis of Heterotopic Ossification?

“…However, critics have raised concerns regarding the use of a potentially malignancy-inducing agent in the treatment of a nonmalignant condition [13,40]. Malignancies, such as neural tumors and sarcoma, were reported after radiation to treat nonmalignant condition with 1000 to 2000 cGy even with latency periods of up to 24 years [37,41,42].…”

Second cancer risk assessments after involved-site radiotherapy for mediastinal Hodgkin lymphoma

“…The out‐of‐field dose calculations derived from a treatment planning system are solely limited to organs depicted by the patients’ CT scans and they are characterized by a limited accuracy especially at points in the far periphery . Different approaches involving either TLD measurements on physical phantoms or Monte Carlo dosimetric calculations on computational phantoms may be employed for reliable out‐of‐field organ dose determination. The average radiation dose received by critical structures excluded from the treatment volume is lower than the OED of the partially in‐field organs …”

“…Different approaches involving either TLD measurements on physical phantoms or Monte Carlo dosimetric calculations on computational phantoms may be employed for reliable out‐of‐field organ dose determination. The average radiation dose received by critical structures excluded from the treatment volume is lower than the OED of the partially in‐field organs …”