Cancer Risk in Children and Young Adults Conceived by In Vitro Fertilization

Källén, Bëngt; Finnström, Orvar; Lindam, Anna; Nilsson, Emma; Nygren, Karl-Gösta; Olausson, Petra Otterblad

doi:10.1542/peds.2009-3225

Cited by 137 publications

(93 citation statements)

References 34 publications

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“…Increased risk of leukemia was observed with 3.8 years earlier in IVF offspring than in the control (OR 2.21, 95% CI 1.27-3.85) (Petridou et al, 2012). Meanwhile, a moderately increased risk of cancer in IVF children (RR 1.42, 95% CI 1.09-1.87) has also been observed by Källén B. et al (2010a) through a follow-up study of 26 692 children who were born after ART between 1982 and2005. In brief, the evidence of cancer risk in children after ART is still very limited. Further studies and long-term follow-up are necessary to determine whether ART had an impact on cancer occurrence.…”

Section: Risk For Cancermentioning

confidence: 89%

Long-term follow-up of children conceived through assisted reproductive technology

Wang

Jin

2013

J. Zhejiang Univ. Sci. B

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Children conceived via assisted reproductive technologies (ART) are nowadays a substantial proportion of the population. It is important to follow up these children and evaluate whether they have elevated health risks compared to naturally conceived (NC) children. In recent years there has been a lot of work in this field. This review will summarize what is known about the health of ART-conceived children, encompassing neonatal outcomes, birth defects, growth and gonadal developments, physical health, neurological and neurodevelopmental outcomes, psychosocial developments, risk for cancer, and epigenetic abnormalities. Most of the children conceived after ART are normal. However, there is increasing evidence that ART-conceived children are at higher risk of poor perinatal outcome, birth defects, and epigenetic disorders, and the mechanism(s) leading to these changes have not been elucidated. Continuous follow-up of children after ART is of great importance as they progress through adolescence into adulthood, and new ART techniques are constantly being introduced.

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Section: Risk For Cancermentioning

confidence: 89%

Long-term follow-up of children conceived through assisted reproductive technology

Wang

Jin

2013

J. Zhejiang Univ. Sci. B

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“…13 Nevertheless, few studies have reported the incidence of cancer in the already large and growing population of children born after fertility treatment and the results are inconsistent. While some studies showed increased risks for all cancers 14 and for specific types of cancer, such as retinoblastoma, 15 neuroblastoma, 6 leukemia, [16][17][18] and hepatoblastoma, 19,20 others found no association. [21][22][23][24][25][26][27][28][29][30][31][32] However, the main part of these studies are characterized by small sample sizes, short follow-up periods and lack of information on the use of fertility drugs.…”

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confidence: 99%

Maternal use of fertility drugs and risk of cancer in children—A nationwide population‐based cohort study in Denmark

Hargreave

Jensen

Nielsen

et al. 2014

Intl Journal of Cancer

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Large population-based studies are needed to examine the effect of maternal use of fertility drugs on the risk of cancer in children, while taking into account the effect of the underlying infertility. A cohort of 123,322 children born in Denmark between 1964 and 2006 to 68,255 women who had been evaluated for infertility was established. We used a case-cohort design and calculated hazard ratios (HRs) for cancer in childhood (0-19 years) and in young adulthood (20-29 years) associated with maternal use of six groups of fertility drugs (clomiphene, gonadotropins [i.e., human menopausal gonadotropins and follicle-stimulating hormone], gonadotropin-releasing hormone analogs, human chorionic gonadotropins, progesterone and other fertility drugs). We found no statistically significant association between maternal use of fertility drugs and risk for overall cancer in childhood or young adulthood. However, with regard to specific cancers in childhood, our results showed that maternal use of progesterone before childbirth markedly increased the risks of their offspring for acute lymphocytic leukemia (any use: HR, 4.95; 95% CI, 1.69-14.54; three cycles of use: HR, 9.96; 95% CI, 2.63-37.77) and for sympathetic nervous system tumors (any use: HR, 5.79; 95% CI, 1.23-27.24; three cycles of use: HR, 8.51; 95% CI, 1.72-42.19). These findings show that maternal use of progesterone may increase the risk for specific cancers in the offspring. Additional large epidemiological studies are urgently needed to confirm our finding.

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“…Källén et al, reported an increased rate of diagnosed histiocytosis in children conceived by means of in vitro fertilization, 6 cases of Langerhans histiocytosis against 1.0 expected [9]. Eosinophilic granuloma is the most common form of LCH, and usually presents as a solitary osteolytic lesion of the skull or spine.…”

Section: Discussionmentioning

confidence: 99%

Unusual Acute Onset of Symptomatic Langerhans Cell Histiocytosis of the Skull: Case Report and Literature Review

Kaloostian¹,

Chen²,

Westhout³

et al. 2013

OJMN

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Introduction: Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the proliferation of specialized bone marrow-derived Langerhans cells (LCs) and mature eosinophils, resulting in solitary or few, indolent and chronic, lesions of bone or other organs called eosinophilic granulomas. Calvarial LCH is quite rare and an underappreciated differential etiology of skull lesions. We present a most unusual case of a young child with hyperacutely symptomatic langerhans histiocytosis of the skull. Method: A 7-year-old male presented with a history of increasing (progressive) frontal headaches of 8 days duration, unaccompanied by associated nausea, vomiting, or diplopia. His only additional complaint was a hard bump on his forehead. MRI and CT done in the ER identified a right fronto-parietal lesion with associated skull erosion. Nuclear medicine and SPECT studies confirmed an erosive skull lesion without significant metabolic activity. A right frontal craniectomy and excision was performed. Results: A soft, rubbery well-circumcised mass coming from the diploic layer of the skull with involvement of bone was identified. The mass had eroded both the outer and inner table of the skull, and the involved area of the right frontal bone was resected. Intra-operative histo-pathologic analysis of the lesion revealed Langerhans cell histiocytosis without involvement of the dura. The patient experienced no neurological worsening as a result of the resection. He was discharged home in stable condition. Conclusion: LCH lesions of the skull are common findings, however, this focal hyperacute symptomatic presentation is most rare and should not deter us from anticipating an erosive bony tumor and planning timely surgical management.

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Cancer Risk in Children and Young Adults Conceived by In Vitro Fertilization

Cited by 137 publications

References 34 publications

Long-term follow-up of children conceived through assisted reproductive technology

Long-term follow-up of children conceived through assisted reproductive technology

Maternal use of fertility drugs and risk of cancer in children—A nationwide population‐based cohort study in Denmark

Unusual Acute Onset of Symptomatic Langerhans Cell Histiocytosis of the Skull: Case Report and Literature Review

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