Cancer risk in DES daughters

Verloop, Janneke; Leeuwen, Flora E. van; Helmerhorst, Theo J.M.; Boven, Hester H. van; Rookus, Matti A.

doi:10.1007/s10552-010-9526-5

Cited by 97 publications

(44 citation statements)

References 25 publications

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“…First, there is no evidence of any increased risk of cancer overall. The DES‐Net project from the Netherlands also found no increase in total cancer risk in DES exposed women compared with the general population [Verloop et al, ], and a French study found no increase in risk of cancers other than breast and CCA [Tournaire et al, ]. Thus, we believe that DES exposure is not likely responsible for substantial excess risks of most of the cancer types we were able to evaluate.…”

Section: Discussionmentioning

confidence: 65%

Prenatal diethylstilbestrol exposure and cancer risk in women

Troisi

Hatch

Titus

et al. 2017

Environ and Mol Mutagen

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In the Diethylstilbestrol [DES] Combined Cohort Follow-up, the age- and calendar-year specific standardized incidence ratio [SIR] for clear cell adenocarcinoma [CCA] was 27.6 (95% confidence interval [CI] 7.51-70.6) for the exposed women. The SIR for breast cancer was 1.17 (95% CI 1.01-1.36) and the hazard ratio [HR] adjusted for birth year and cohort for comparison with the unexposed was 1.05 (95% CI 0.79-1.41). The SIR for pancreatic cancer was 2.43 (95% CI 1.21-4.34) and the adjusted HR for comparison with unexposed women was 7.16 (95% CI 0.84-61.5). There was little evidence of excess risk for other sites. There appeared to be a deficit in risk for endometrial cancer among the exposed (SIR 0.61; 95% CI 0.35-0.98), and an excess in the unexposed (SIR 1.55; 95% CI 0.95-2.40); the adjusted HR was 0.45 (95% CI 0.22-0.93) for the internal comparison. There was no overall excess cancer risk in exposed women compared with general population rates (1.06; 95% CI 0.95-1.17) or with unexposed participants (adjusted HR 1.03; 95% CI 0.84-1.25). These data do not support the suggestion that there is a diathesis of cancers in DES exposed female offspring The excess risk of breast and pancreatic cancers that we observed is concerning and warrants continued follow-up and mechanistic investigation. Environ. Mol. Mutagen, 2017. Published 2017. This article is a US Government work and is in the public domain in the USA.

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Section: Discussionmentioning

confidence: 65%

Prenatal diethylstilbestrol exposure and cancer risk in women

Troisi

Hatch

Titus

et al. 2017

Environ and Mol Mutagen

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“…33 In addition, DES daughters have also been shown to be at increased risk for breast cancer, genital tract abnormalities, complications of pregnancy (eg, ectopic pregnancy, preterm delivery, neonatal death), and melanoma. 34–36 DES sons have higher rates of genital tract abnormalities, such as hypospadias, epididymal cysts, and cryptorchidism, than nonexposed male subjects. 37,38 Animal studies and early epidemiologic studies also questioned an increased risk of testicular cancer in DES sons, although there is currently no evidence to support this assertion.…”

Section: Diethylstilbestrolmentioning

confidence: 97%

Drugs and Medical Devices: Adverse Events and the Impact on Women’s Health

Carey

Nader

Chai

et al. 2017

Clinical Therapeutics

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A large number of medications and medical devices removed from the market by the US Food and Drug Administration over the past 4 decades specifically posed greater health risks to women. This article reviews the historical background of sex and gender in clinical research policy and describes several approved drugs and devices targeted for use in women that have caused major morbidity and mortality. The intended population for the medications and devices, population affected, approval process, and the basic and legal actions taken against the medication/drug company are also discussed. It is recognized that women are still at risk for harm from unsafe medications and devices, and continued improvements in legislation that promotes inclusion of sex and gender into the design and analysis of research will improve safety for both men and women.

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“…A moderate increase in breast cancer risk has been shown both in women who were treated with DES during pregnancy, and their daughters [82]. Hsu et al have demonstrated that the expression of 82 miRNAs (9.1% of the 898 miRNAs evaluated) were altered in breast epithelial cells when exposed to DES [83].…”

Section: Environmental Chemicals and Mirnamentioning

confidence: 99%

Environmental chemicals and microRNAs

Hou

Wang

Baccarelli³

2011

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

149

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MicroRNAs (miRNAs) are short single-stranded non-coding molecules that function as negative regulators to silence or suppress gene expression. Aberrant miRNA expression has been implicated in a several cellular processes and pathogenic pathways of a number of diseases. Evidence is rapidly growing that miRNA regulation of gene expression may be affected by environmental chemicals. These environmental exposures include those that have frequently been associated with chronic diseases, such as heavy metals, air pollution, bisphenol A, and cigarette smoking. In this article, we review the published data on miRNAs in relation to the exposure to several environmental chemicals, and discuss the potential mechanisms that may link environmental chemicals to miRNA alterations. We further discuss the challenges in environmental-miRNA research and possible future directions. The cumulating evidence linking miRNAs to environmental chemicals, coupled with the unique regulatory role of miRNAs in gene expression, makes miRNAs potential biomarkers for better understanding the mechanisms of environmental diseases.

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Cancer risk in DES daughters

Cited by 97 publications

References 25 publications

Prenatal diethylstilbestrol exposure and cancer risk in women

Prenatal diethylstilbestrol exposure and cancer risk in women

Drugs and Medical Devices: Adverse Events and the Impact on Women’s Health

Environmental chemicals and microRNAs

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