Cancer risk in hospitalised psoriasis patients: a follow-up study in Sweden

Abstract

We examined overall and specific cancer risks among Swedish subjects who had been hospitalised one or more times for psoriasis. A database was created by identifying such patients from the Swedish Hospital Discharge Register and linking them with the Cancer Registry. Follow-up of patients was carried out from the last hospitalisation through 2004. A total of 15 858 patients were hospitalised for psoriasis during 1965 -2004, of whom 1408 developed cancer, giving an overall standardised incidence ratios (SIRs) of 1.33. A significant excess was noted for squamous cell skin cancer, and for cancers of the upper aerodigestive tract, oesophagus, stomach, liver, pancreas, lung, kidney and bladder as well as non-Hodgkin lymphoma. Many of these may reflect the effects of alcohol drinking and tobacco smoking. Patients with multiple hospitalisations showed high risk, particularly for oesophageal (SIR 6.97) and skin (SIR 4.76) cancers.

Sarcoidosis and subsequent cancer risk: a Danish nationwide cohort study

“…In agreement with previous studies [2,4,5,14], we also found an increased risk of Hodgkin lymphoma and skin cancer. Moreover, we found a persistent strong association between sarcoidosis and non-Hodgkin lymphoma, which has been less clearly described [2,4,5,15].…”

“…Our finding of an increased overall risk of cancer among sarcoidosis patients is in accordance with several previous studies using the general population as a comparison [2][3][4][5][6], while one study found no association when comparing sarcoidosis patients with other hospitalised patients [12].…”

“…We confirmed a substantially increased risk of lung cancer during the first 3 months, which was also previously reported [2], but thereafter the risk declined substantially. Regarding the long-term risk of lung cancer, we supported the finding of a decreased risk [12].…”

“…Moreover, we found a persistent strong association between sarcoidosis and non-Hodgkin lymphoma, which has been less clearly described [2,4,5,15].…”

Psoriasis, cardiovascular events, cancer risk and alcohol use: evidence‐based recommendations based on systematic review and expert opinion

“…Among the 12 studies analysing risk of lymphoma in psoriasis compared to controls, seven showed an association between total lymphoma, [28][29][30] Hodgkin lymphoma, 30,31 nonHodgkin lymphoma [31][32][33][34] and psoriasis. Two studies 30,34 specifically assessed the risk of skin lymphoma in psoriasis and found an increased risk of cutaneous T-cell lymphomas (CTCL) associated with psoriasis.…”