Cancer risk in patients hospitalised for Graves’ disease: a population-based cohort study in Sweden

Shu, Xiaochen; Ji, Jianguang; Li, Xinjun; Sundquist, Jan; Sundquist, Kristina; Hemminki, Kari

doi:10.1038/sj.bjc.6605624

Cited by 64 publications

(63 citation statements)

References 24 publications

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“…GD has been associated with a 10- to 12-fold increased risk of TC [8, 9]. It is, however, unclarified whether this observation is due to a chance finding, due to more extensive examination of affected individuals, or indicates a direct carcinogenic effect of GD.…”

Section: Discussionmentioning

confidence: 90%

“…The etiology of GD is inadequately understood, but is generally thought to be the result of interactions between genetic [3] and environmental triggers, of which cigarette smoking [4, 5] and iodine intake [6] have received most attention. Patients with GD have an increased burden of other morbidities [7], including an increased risk of thyroid cancer (TC) [8, 9], although surveillance bias may, at least partly, explain the latter. Whether GD, which is associated with excess mortality [10], affects the prognosis of differentiated TC is still a matter of controversy [11-14].…”

Section: Introductionmentioning

confidence: 99%

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Total Thyroidectomy for Thyroid Cancer Followed by Thyroid Storm due to Thyrotropin Receptor Antibody Stimulation of Metastatic Thyroid Tissue

Folkestad¹,

Brandt²,

Brix³

et al. 2017

Eur Thyroid J

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Background: Graves disease (GD) is an autoimmune condition characterized by the presence of antibodies against the thyrotropin receptor (TRAB), which stimulate the thyroid gland to produce excess thyroid hormone. Theoretically, TRAB could stimulate highly differentiated thyroid cancer tissue and/or metastases to produce thyroid hormone. Case: A 68-year-old male, with weight loss and palpitations, was diagnosed with thyrotoxicosis. A later MRI, due to persistent shoulder pain, revealed multiple bone metastases. A biopsy was diagnostic for follicular variant of papillary thyroid carcinoma, and total thyroidectomy was performed. One week after thyroidectomy the patient was admitted with severe hyperthyroidism. TRAB was >40 IU/mL (normal <0.7 IU/mL). High-dose antithyroid drug treatment was followed by high-dose radioactive iodine-131 (RAI) and local radiotherapy covering the right shoulder. Antithyroid drug treatment continued until after the fourth RAI dose. Hypothyroidism did not occur until following the fifth RAI treatment. Summary and Conclusions: We present a patient initially diagnosed with thyrotoxicosis and subsequently with metastatic follicular variant of papillary thyroid cancer. It is suggested that TRAB stimulated the highly differentiated extrathyroidal metastatic thyroid tissue to produce excessive amounts of thyroid hormone, delayed diagnosis, and potential aggravation of the course of thyroid cancer.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Total Thyroidectomy for Thyroid Cancer Followed by Thyroid Storm due to Thyrotropin Receptor Antibody Stimulation of Metastatic Thyroid Tissue

Folkestad¹,

Brandt²,

Brix³

et al. 2017

Eur Thyroid J

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“…For example, using a series of nested, case controls in the ORLS, Goldacre and colleagues examined links between gall bladder disease and colon cancer, appendectomy and inflammatory bowel disease, vasectomy and prostate disease, and mumps immunization and aseptic meningitis (30,49,62). Similarly, using Swedish MigMed data, Sundquist and colleagues (80) have examined Graves' disease and risks of several cancers. Such matched set analysis can be done for any comparison of choice (23).…”

Section: Population-based Cohort and Case-control Studiesmentioning

confidence: 99%

Administrative Record Linkage as a Tool for Public Health Research

Jutte

Roos

Brownell

2011

Annu. Rev. Public Health

278

247

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Linked administrative databases offer a powerful resource for studying important public health issues. Methods developed and implemented in several jurisdictions across the globe have achieved high-quality linkages for conducting health and social research without compromising confidentiality. Key data available for linkage include health services utilization, population registries, place of residence, family ties, educational outcomes, and use of social services. Linking events for large populations of individuals across disparate sources and over time permits a range of research possibilities, including the capacity to study lowprevalence exposure-disease associations, multiple outcome domains within the same cohort of individuals, service utilization and chronic disease patterns, and life course and transgenerational transmission of health. Limited information on variables such as individual-level socioeconomic status (SES) and social supports is outweighed by strengths that include comprehensive follow-up, continuous data collection, objective measures, and relatively low expense. Ever advancing methodologies and data holdings guarantee that research using linked administrative databases will make increasingly important contributions to public health research.

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“…Hypothyroid function was not associated with cancer risk. 9 The largest to date longitudinal cohort study evaluating cancer risk in patients hospitalized for Graves' disease (GD) was published in 2010 by Shu et al 10 In this cohort of 18,156 GD patients, a total of 1,495 who developed cancers during a median follow-up period of 17 years was observed (overall incidence ratio: 1.13, 95%CI: 1.07-1.19). The overall excess of all cancers (13%) was largely attributable to cancers of the thyroid, other endocrine glands, upper aerodigestive tract, and breast.…”

mentioning

confidence: 99%

“…The overall excess of all cancers (13%) was largely attributable to cancers of the thyroid, other endocrine glands, upper aerodigestive tract, and breast. 10 The relationship between benign thyroid diseases and breast cancer is a long-debated issue that has been investigated for over 50 years and a disparity in results appears relatively commonly throughout the literature. A recent meta-analysis has been written with the purpose of collating and analyzing available data from 28 studies, calculating a pooled odd ratio (OR) of the risk of breast cancer in patients diagnosed with benign thyroid diseases.…”

mentioning

confidence: 99%