Cancer risk in <scp>J</scp>apanese <scp>C</scp>rohn's disease patients: Investigation of the standardized incidence ratio

Yano, Yutaka; Matsui, Toshiyuki; Hirai, Fumihito; Okado, Yuki; Sato, Yuho; Tsurumi, Kozue; Ishikawa, Satoshi; Beppu, Tsuyoshi; Koga, Akihiro; Yoshizawa, Naoyuki; Higashi, Daijiro; Futami, Kitaro

doi:10.1111/jgh.12189

Cited by 47 publications

(25 citation statements)

References 22 publications

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“…As for the risk of colorectal cancer in patients with CD, the most notable finding is that 89-100% of colorectal cancers occur in the rectum in Korea [62] and Japan [63,64] ; in contrast, only 40% of colorectal cancers in the West are rectal [65] . How can this difference be explained?…”

Section: Colorectal Cancermentioning

confidence: 99%

How Does the Epidemiology of Inflammatory Bowel Disease Differ between East and West? A Korean Perspective

Yang¹

2017

Inflamm Intest Dis

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Background: Though low compared with those in Western countries, the incidence and prevalence of inflammatory bowel disease (IBD) are rapidly increasing in Asia. If we could understand the differences in IBD epidemiology between Asian and Western countries, we might gain insights into the etiopathogenesis of IBD as well as guidance for personalized therapy. Summary: In Asia, unlike in the West, Crohn's disease (CD) predominantly occurs in men and involves a high prevalence of perianal fistulas. Moreover, in Korean CD patients, ileocolonic involvement is predominant, whereas isolated colonic involvement is very uncommon. In both ulcerative colitis (UC) and CD, extraintestinal manifestations, such as primary sclerosing cholangitis, as well as a positive family history of IBD are less frequent in Asian patients. However, as the prevalence of IBD rises in Korea, so does the frequency of a positive family history. While the colectomy rate among Korean UC patients is lower, the intestinal resection rate in CD patients is similar in Korea and in the West. Infectious problems that can adversely influence IBD management are usually more common in Asia. Key Messages: IBD in Asians differs from that in Westerners in many aspects, including demographic and clinical characteristics, prognosis, and associated problems.

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Section: Colorectal Cancermentioning

confidence: 99%

How Does the Epidemiology of Inflammatory Bowel Disease Differ between East and West? A Korean Perspective

Yang¹

2017

Inflamm Intest Dis

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“…[33]. It has also been reported in Japan that the SIR for CRC is 2.79-5.8 [34,35]. Higashi et al reported that the frequency of comorbid CRC in CD from multiple facilities specialized for IBD was 3.5% (122/3454 patients), and that the 5-year survival rate of CRC was 88% in Stage I, 68% in Stage II, 71% in Stage IIIa, 25% in Stage IIIb, and 0% in Stage IV [36].…”

Section: Discussionmentioning

confidence: 99%

Crohn’s disease-specific mortality: a 30-year cohort study at a tertiary referral center in Japan

et al. 2018

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Background In this study, survival and cause of death were investigated in patients with Crohn's disease (CD) at a tertiary referral center. Methods A database was created based on the medical records of 1108 CD patients who had a history of visiting our hospital to investigate background characteristics, cumulative survival rates from diagnosis, causes of death, and the standardized mortality ratio (SMR) for each cause of death. A follow-up questionnaire survey of patients followed up inadequately was also conducted. The cumulative survival rate from diagnosis was determined using the life table method and compared with that of a sex-and age-matched population model from the year 2000. Results The study included 1108 patients whose mean age at diagnosis was 25.6 ± 10.8 years. The mean duration of follow-up was 14.6 ± 9.4 years, and there were 52 deaths. The cumulative survival rate was significantly lower 25 years after the diagnosis of CD (91.7%) than in the standard population model (95.7%). SMRs for both all causes [3.5; 95% confidence interval (CI): 2.7-4.6] and CD-specific causes (36.7; 95% CI 26.1-51.6) were high. Among the CD-specific causes, SMRs were especially high for small intestine and colorectal cancers, gastrointestinal diseases including intestinal failure (IF), perioperative complications, and amyloidosis. Conclusion The SMRs for both all causes and CD-specific causes were high in CD patients. CD-specific causes including intestinal cancer, IF, perioperative complications, and amyloidosis showed especially high SMRs.

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“…It is known that the most lethal long term complication of IBD is colorectal cancer (CRC), the risk of its development significantly increases in the patients of IBD. Patients with UC and CD bear an about 10-and 4-fold increased risk, respectively [1,30,31].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Bowel Disease: Anatomical and Histopathological Study

Hegazy¹

2015

IJCDA

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Worldwide, the frequency of chronic inflammatory bowel disease (CIBD), including ulcerative colitis (UC) and Crohn's disease (CD) increased rapidly through the last century making their histopathological diagnosis daily task for all pathologists. The accurate histopathological diagnosis of UC and CD requires an intimate correlations between the clinical, laboratory and endoscopic findings in conjunction to the suitable obtained biopsy material, as there are several diagnostic confusions between CIBD and non CIBD forms. The aim of this study was to focus and analyze certain practically selected histopathological features for the diagnosis of UC and CD including crypt architectural abnormalities, inflammation and an associated dysplasia or adenocarcinoma. This present study was performed on 100 specimens of tissue samples taken from small and large bowel including 3 ileocecal resections which were done for suspected an IBD. All the tissue samples received fixed in 10% neutral buffered formalin fixative solution, and paraffin-embedded tissue sections were prepared and examined microscopically for the histopathological features which distinguishing CIBD from non CIBD colitis. This study revealed 95 cases CIBD, among them 55 cases CD and 40 cases were UC, whereas the remaining 5 cases were non CIBD colitis. This study concluded that the diagnosis of IBD needs interdepartmental correlations to avoid under-or over-diagnosis. As well as the accurate discrimination of CIBD from non CIBD forms, differentiate UC from CD, and to identify any dysplastic lesions which is the backbone for therapeutic and prognostic strategies.

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Cancer risk in Japanese Crohn's disease patients: Investigation of the standardized incidence ratio

Abstract: Among the cancers in CD patients in our hospital, no significant difference was seen in the risk for all cancers in comparison with the standard population. However, the risks for CRC and leukemia were significantly higher than in the standard population.

Cited by 47 publications

References 22 publications

How Does the Epidemiology of Inflammatory Bowel Disease Differ between East and West? A Korean Perspective

How Does the Epidemiology of Inflammatory Bowel Disease Differ between East and West? A Korean Perspective

Crohn’s disease-specific mortality: a 30-year cohort study at a tertiary referral center in Japan

Inflammatory Bowel Disease: Anatomical and Histopathological Study

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