Cancer risk‐reducing surgery: Brazilian society of surgical oncology guideline part 1 (gynecology and breast)

Abstract

Background Risk‐reducing operations are an important part of the management of hereditary predisposition to cancer. In selected cases, they can considerably reduce the morbidity and mortality associated with cancer in this population. Objectives The Brazilian Society of Surgical Oncology (BSSO) developed this guideline to establish national benchmarks for cancer risk‐reducing operations. Methods The guideline was prepared from May to December 2021 by a multidisciplinary team of experts to discuss the surgical management of cancer predisposition syndromes. Fourteen questions were defined and assigned to expert groups that reviewed the literature and drafted preliminary recommendations. Following a review by the coordinators and a second review by all participants, the groups made final adjustments, classified the level of evidence, and voted on the recommendations. Results For all questions including risk‐reduction bilateral salpingo‐oophorectomy, hysterectomy, and mastectomy, major agreement was achieved by the participants, always using accessible alternatives. Conclusion This and its accompanying article represent the first guideline in cancer risk reduction surgery developed by the BSSO, and it should serve as an important reference for the management of families with cancer predisposition.

Germline mutations in BRCA1 and BRCA2 among Brazilian women with ovarian cancer treated in the Public Health System

“…Identifying a germline mutation in BRCA1 and BRCA2 favors personalized treatments (e.g., poly ADP-ribose polymerase inhibitors), preventive strategies (e.g., genetic counseling, specific screening, and risk-reducing surgeries [e.g., salpingo-oophorectomy or mastectomy]), and a better cost-effective relationship for the health system [8][9][10].…”