Cancer risks from betel quid chewing beyond oral cancer: a multiple-site carcinogen when acting with smoking

Wen, Chi Pang; Tsai, Min Kuang; Chung, Wen Shen Isabella; Hsu, Hui Ling; Chang, Yen Chen; Chan, Hui Ting; Chiang, Po Huang; Cheng, Ting; Tsai, Shan P.

doi:10.1007/s10552-010-9570-1

Cited by 106 publications

(99 citation statements)

References 25 publications

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“…It has been estimated that there are 600 million betel quid chewers worldwide (Wen et al, 2010). People who chew betel quid but do not smoke cigarettes or consume alcohol were reported to have an odds ratio of 10.97 (95% confidence interval: 3.22-37.34) for contracting oral cancer (Yen et al, www.intechopen.com…”

Section: Betel Quid Chewingmentioning

confidence: 99%

“…Arecoline was found to inhibit P53, repress DNA repair, and trigger DNA damage response in human epithelial cells via an in-vitro study (Tsai et al, 2008). Chewing betel quid induces local irritation and trauma in the oral mucosa, leading to chronic inflammation, oxidative stress, and cytokine production, and the traumatic wound offers easier access to the system for carcinogens contained in betel quid (Wen et al, 2010). Betel quid chewing not only causes genomic instability, but also has a close relationship with cell-mediated immunity, which could play a role in the malignant transformation of oral mucosa (Yen et al, 2008).…”

Section: A Literature Analysis Of the Risk Factors For Oral Cancer 69mentioning

confidence: 99%

“…Many studies have found that there is a synergic effect of cigarette smoking, alcoholic consumption, and betel quid chewing in carcinogenesis of oral cavity mucosa (Castellsagué et al, 2004;Chang et al, 2001;Ko et al, 1995;Szymańska et al, 2011;Wen et al, 2010;Yen et al, 2008). Patients who smoked and also consumed alcohol had an odds ratio of 9.03 for contracting oral cavity cancers, whereas patients who only smoke or only consumed alcohol had odds ratios of 4.65 and 0.95, respectively when compared with abstainers (Yen et al, 2008).…”

Section: Synergistic Effectmentioning

confidence: 99%

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A Literature Analysis of the Risk Factors for Oral Cancer

Liu¹

2012

Oral Cancer

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Section: Betel Quid Chewingmentioning

confidence: 99%

Section: A Literature Analysis Of the Risk Factors For Oral Cancer 69mentioning

confidence: 99%

Section: Synergistic Effectmentioning

confidence: 99%

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A Literature Analysis of the Risk Factors for Oral Cancer

Liu¹

2012

Oral Cancer

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“…Worldwide smoking accounts for 42 % of oropharyngeal cancer [2]. In India, Taiwan and other neighboring countries smokeless tobacco and betal quids are the major risk factors for increasing incidences of oral cancer [4,5]. The primary treatment protocol is surgical resection of the involved site along with radiation therapy and chemotherapy which often causes facial disfigurement and difficulties in mastication, deglutition and speech resulting in a high level of morbidity with significant psychological implications [6].…”

Section: Introductionmentioning

confidence: 99%

Rehabilitation of Post Surgical Maxillectomy Defects Using Interim Obturators—A Case Series

Choudhury

Shanmuganathan

Padmanabhan

et al. 2014

Indian J Surg Oncol

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Prosthetic rehabilitation of extensive maxillectomy defects are exigent given the difficulties faced due to loss of palatal bone,teeth and surrounding supporting tissues which help in retention, support and stability of the prosthesis. An interim maxillary obturator is a prosthesis which is made after surgical resection of a portion or all of one or both maxilla where initial healing is completed. Frequently many or all teeth in the defect area are replaced by this prosthesis. It plays a vital role in preventing the facial disfigurement and irritation to the surgical site thereby enhancing the healing and restores the functional capabilities such as speech, mastication, deglutition etc. To gain better retention and stability, preservation of the unaffected regions is needed which can be achieved by proper surgical planning and designing of the prosthesis. This case series describes rehabilitation of three extensive maxillectomy defects with hollow open and closed interim obturators.

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“…[75][76][77] People who chew areca nut, but do not smoke or consume alcohol, have an odds ratio of 10.97 (3.22 ~ 37.34 95%CI) for developing oral cancer. 58,78 There is also significant epidemiological evidence of a synergistic effect between tobacco, alcohol, and areca nut consumption in the development of oral cancer.…”

Section: Areca Nut Consumptionmentioning

confidence: 99%

Opportunities for achieving early diagnosis of oral cancer within the medical profession in Australia

Webster¹

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Most oral cancers lack early symptoms that would prompt a patient to seek diagnosis; hence at presentation more than 60% of patients are diagnosed with stage III or IV advanced disease. Survival rates and morbidity are dramatically improved if the disease is treated at an early stage, preferably asymptomatic in stage one. Therefore, early detection of oral cancer and oral potentially malignant lesions in the asymptomatic phase via an oral cancer screening examination is important.The core objective of this thesis is to determine whether asymptomatic diagnosis of oral cancer at an early stage of disease is achievable in Australia. We achieve this by evaluating the awareness of, and attitudes toward, oral cancer and opportunistic screening held by recently-diagnosed oral cancer patients, experienced general medical practitioners, and recentlygraduated medical students. From these studies we found that participants with oral cancer had poor awareness of oral cancer and poor knowledge of risk factors prior to diagnosis. Nearly all were over 40 years of age and most consumed tobacco or alcohol or both, suggesting a target population for opportunistic screening in the primary healthcare setting. Patient, professional, and total diagnostic ii delay were better than in many other countries. In the asymptomatic phase before diagnosis, participants with oral cancer were more likely to visit a GMP over a General Dental Practitioner (GDP), and likely to do so multiple times each year, identifying significant opportunities for GMPs to perform opportunistic oral cancer screening.We also found that Australian GMPs and GMSs have an inadequate level of knowledge of oral cancer, OPMLs, risk factors, and inadequate skill in performing opportunistic oral cancer screening examinations. At the present level of knowledge and confidence, it would be unlikely for a GMP to conduct a thorough visual and tactile oral cancer screening examination even if a highrisk individual presented to his or her clinic. Only 7% of participants with oral cancer were diagnosed in the asymptomatic phase, and all were diagnosed by health practitioners with a dental qualification.We conclude that asymptomatic diagnosis of oral cancer at an early stage of disease is achievable in the primary medical healthcare setting in Australia via opportunistic oral cancer screening. Initiating a consultation with a GMP or GDP for an oral cancer screening examination would require a patient to have an improved awareness of oral cancer and knowledge of his or her personal risk factors for developing it. To increase opportunistic oral cancer screening activity from Australian GMPs, interventions need to ensure that GMPs and GMSs reach competence in risk factors for oral cancer, identifying high-risk populations, diagnostic confidence, and skill in performing the nine-step visual and tactile opportunistic oral cancer screening examination.iii

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Cancer risks from betel quid chewing beyond oral cancer: a multiple-site carcinogen when acting with smoking

Cited by 106 publications

References 25 publications

A Literature Analysis of the Risk Factors for Oral Cancer

A Literature Analysis of the Risk Factors for Oral Cancer

Rehabilitation of Post Surgical Maxillectomy Defects Using Interim Obturators—A Case Series

Opportunities for achieving early diagnosis of oral cancer within the medical profession in Australia

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