Purpose: The impact of genetic cancer risk assessment on communication of cancer risk information within families is not fully known. We compared women's selection of family members for cancer risk communication and perceived barriers to this communication before genetic cancer risk assessment and 6 months afterward.Methods: Mailed surveys were used to collect prospective data from consenting women undergoing genetic cancer risk assessment because of a personal and/or family history of breast or ovarian cancers. Analysis included descriptive statistics, chi-square and McNemar tests, and paired t tests. Results: A total of 122 women met the study criteria. Although risk communications increased with first-degree relatives (84%-90% for females; 53%-62% for males) and decreased with non-first-degree relatives (21%-9%) before and after genetic cancer risk assessment, the degree of change was nonsignificant. The most commonly cited communication barrier was loss of contact (30%). Demographics, personal or family cancer history, and BRCA status did not significantly influence findings. Conclusions: There was a high degree of cancer risk communications with female first-degree relatives, but less so with male first-degree relatives, both before and after genetic cancer risk assessment. In the United States, breast cancer is the most common cancer in women and is second only to lung cancer in cancerrelated deaths for women. 1 Although ovarian cancer strikes far fewer women, the mortality rate is disproportionately higher, often because of insufficient early diagnostic tools. Risks for these cancers vary greatly. For instance, breast cancer risk for women with a single first-degree relative (FDR) with postmenopausal breast cancer may be 15% versus 12% risk for the general population by age 80 years. Ovarian cancer risk for a woman with a single FDR with the disease is approximately 5%, versus the 1.6% risk for the general population. 2-5 However, breast cancer risk for women who carry a BRCA gene mutation ranges from approximately 30% to 50% by age 50 years to as high as 87% by age 80 years in some families, with a 40% to 60% risk for a second primary breast cancer. 6 -8 The associated risk for ovarian cancer is approximately 15% to 45%, with onset generally after age 40 years rather than after age 60 years in the general population. 6,7,9 Siblings and offspring of BRCA mutation carriers are at a 50% risk for inheriting the mutation. Because men rarely develop breast cancer and are not at risk for ovarian cancer, BRCA-associated risk may be masked by male transmission and unrecognized by both clinicians and patients.Since the advent of commercial BRCA testing approximately a decade ago, genetic cancer risk assessment (GCRA) has been increasingly integrated into women's health care to provide individuals and their families with age-and risk-level appropriate cancer screening and risk-reduction strategies. GCRA is typically conducted by a physician and nurse or genetic counselor team with expertise in genetics and/or onco...