Cancer secretomics reveal pathophysiological pathways in cancer molecular oncology

Abstract

A B S T R A C TEmerging proteomic tools and mass spectrometry play pivotal roles in protein identifica-

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

“…Tumor-produced exosomes have drawn more and more attention lately (11)(12)(13). Exosomes are involved in autocrine signaling promotion in tumor progression through exchange between tumor cells (14,15). Neighboring and distant tumor cells can receive information from tumor exosomes (9,16).…”

Proteomic Profiling of Androgen-independent Prostate Cancer Cell Lines Reveals a Role for Protein S during the Development of High Grade and Castration-resistant Prostate Cancer

“…High throughput proteomics is a growing field that can virtually be used to study the proteomic signature of any biological material (13). Numerous studies have been conducted using proteomics to identify biomarkers for prostate cancer using cell lines, tissues, and biological fluids, including expressed prostatic secretions (14 -21).…”

Proteomics - A Powerful Tool to Deepen the Molecular Mechanisms of Aortic Stenosis Disease

“…Most studies are focused on the secretome obtained from in vitro cell cultures, assuming that such cells' behavior well simulates the in vivo condition (Roelofsen et al, 2009). In particular, the cancer secretome, namely the whole collection of proteins secreted by cancer cells through various secretory pathways, has recently been shown to have significant potential, as secreted proteins might represent putative tumor biomarkers or therapeutic targets (Karagiannis et al, 2010). The most perfect approximation to the real situation is the study of the in vivo secretome.…”