Cancer staff in an NHS cancer center: infections, vaccination, stress and well-being support during the COVID-19 pandemic

Hadi, Hajer; Handford, Jasmine; Russell, Beth; Moss, Charlotte; Monroy‐Iglesias, Maria J.; Rammant, Elke; Smith, Susan M; Dolly, Saoirse; Thillai, Kiruthikah; Rigg, Anne; Hemelrijck, Mieke Van

doi:10.2217/fon-2022-0071

Cited by 1 publication

(1 citation statement)

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“…Many studies have shown that the administration of COVID‐19 vaccine to patients receiving ICIs may result in an increased risk of irAEs due to the immunogenic effect of vaccination 66,67 . To date, there is insufficient evidence to confirm the correlation between both COVID‐19 vaccine and ICIs.…”

Section: Discussionmentioning

confidence: 99%

Serological response and immune‐related adverse events following COVID‐19 vaccination in cancer patients treated with immune checkpoint inhibitors: A systematic review and meta‐analysis

Wang,

Chen,

Pan

et al. 2023

Reviews in Medical Virology

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With the popularity of Coronavirus disease 2019 (COVID‐19) vaccine and the development of vaccination strategies, the impact of COVID‐19 vaccine on cancer patients receiving immune checkpoint inhibitors (ICIs) is still unclear. In the systematic review and meta‐analysis of patients with ICIs, we assessed the serological response of cancer patients receiving COVID‐19 vaccine, and explored the risk of immune related adverse events (irAEs). We searched PubMed, EMBASE and Cochrane Library as of 10 June 2023, and included cancer patients who received ICIs and COVID‐19 vaccine. The systematic review and meta‐analysis include cohort study, cross‐sectional study and case report. The outcome included the serological response, Spike‐specific T‐cell response, irAEs and rare adverse events. When possible, the data were analysed by random effect analysis, and the statistical heterogeneity was assessed by Q‐test and I2 statistics. We explored the sources of heterogeneity through L’Abbe plots, Galbraith radial plots, and sensitivity analysis. The publication bias was evaluated by Egger's, Begg's linear regression test and funnel plot, and the impact of publication bias was further analysed by trim and fill method. 27 studies were eligible (19 cohort studies, 1 cross‐sectional study and 7 case reports), involving 8331 patients (with 4724 receiving ICIs). Most studies used mRNA vaccine (BNT162b2 or mRNA‐1273). Compared with cancer patients receiving chemotherapy, cancer patients receiving ICIs were significantly more likely to have seroconversion (RR = 1.05, 95%CI 1.01–1.10, P = 0.02). There were no statistically significant differences in seroconversion rates when comparing cancer patients receiving ICIs with controls without cancer (RR = 0.95, 95% CI 0.89–1.01, P = 0.09) or with cancer patients receiving targeted therapy (RR = 1.05, 95% CI 0.79–1.39, P = 0.75). The incidence of irAEs in patients receiving ICIs before and after COVID‐19 vaccination was (21.96%, 95%CI 16.66%–28.94%) and (14.88%, 95%CI 8.65%–25.57%), respectively. The most common irAEs were endocrine abnormalities, skin disorders, etc. The certainty of evidence was low in cancer patients with ICIs, compared with those receiving chemotherapy, and very low versus controls without cancer. Cancer patients treated with ICIs seem to be able to receive COVID‐19 vaccine safely without increasing the incidence of irAEs.

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Section: Discussionmentioning

confidence: 99%