Cancer Stem Cells in Lung Cancer: Distinct Differences between Small Cell and Non-Small Cell Lung Carcinomas

Okihara, Koji; Nagahara, Noriyuki; Katayama, Akira; Kitamura, Hitoshi

doi:10.5772/13913

Cited by 1 publication

(1 citation statement)

References 97 publications

(148 reference statements)

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“…Furthermore, cellular markers are difficult to stand alone and have to be used in combination of other markers in order to improve the selection of CSCs. However, targeting CSCs in lung would be challenge due to heterogeneity ( 123 ) of the cells and various genomic pathways involved. Therefore, many studies are focusing on using combination of cellular markers as it increase the specificity of targeted population.…”

Section: Challenges In Lung Cscsmentioning

confidence: 99%

Targeting Lung Cancer Stem Cells: Research and Clinical Impacts

et al. 2017

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Lung cancer is the most common cancer worldwide, accounting for 1.8 million new cases and 1.6 million deaths in 2012. Non-small cell lung cancer (NSCLC), which is one of two types of lung cancer, accounts for 85–90% of all lung cancers. Despite advances in therapy, lung cancer still remains a leading cause of death. Cancer relapse and dissemination after treatment indicates the existence of a niche of cancer cells that are not fully eradicated by current therapies. These chemoresistant populations of cancer cells are called cancer stem cells (CSCs) because they possess the self-renewal and differentiation capabilities similar to those of normal stem cells. Targeting the niche of CSCs in combination with chemotherapy might provide a promising strategy to eradicate these cells. Thus, understanding the characteristics of CSCs has become a focus of studies of NSCLC therapies.

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Section: Challenges In Lung Cscsmentioning

confidence: 99%