Cancer Stem Cells in Ovarian Cancer—A Source of Tumor Success and a Challenging Target for Novel Therapies

Wilczyński, Jacek R.; Wilczyński, Miłosz; Paradowska, Edyta

doi:10.3390/ijms23052496

Cited by 32 publications

(29 citation statements)

References 470 publications

(510 reference statements)

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“…Tumoral heterogeneity has been supported by the presence and the maintenance of cancer cells with stemness ability. The CSC model proposed in many studies suggests that this specific subpopulation of cells within the tumor is responsible for disease progression and relapse after standard treatments [ 22 ]. The tumor progression requires different abilities by the subclones, which are present in cells that share stemness profile in Oral and HNSCC, giving a particular marker signature diversity that could result from its functional and molecular plasticity [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…CSCs maintain a cross-talk with immune cells in the TME to promote an immunosuppressive milieu that allows tumor development as a result of escape from the host's immune surveillance [ 22 ]. However, the mechanisms displayed by CSCs that enable their survival under immune vigilance during HNSCC tumorigenesis and metastasis are not well-established [ 23 ].…”

Section: Hncscs and Escape From The Host Immune Surveillancementioning

confidence: 99%

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Mechanisms of immune evasion by head and neck cancer stem cells

Xavier

Silva

Rodini

et al. 2022

Front. Oral. Health

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Different mechanisms are involved in immune escape surveillance driven by Oral and Head and Neck Cancer Stem Cells (HNCSCs). The purpose of this review is to show the most current knowledge regarding the main impact of HNCSCs on tumor evasion through immunosuppression, CSCs phenotypes and environmental signals, highlighting strategies to overcome immune evasion. The main results drive the participation of cell surface receptors and secreted products and ligands, the crosstalk between cells, and genetic regulation. The reduction in CD8+ T cell recruitment and decreased effector of anti-PD-1 therapy by cells expressing BMI1 is a key event; Natural Killer cell ligands and cytokines needed for its activation and expansion are crucial to control tumor growth and to target CSCs by immunotherapy; CSCs expressing ALDH1 are related to increased expression of PD-L1, with a positive link between DNMT3b expression; CD276 expression in CSCs can act as a checkpoint inhibitor and together with Activator Protein 1 (AP-1) activation, they create continuous positive feedback that enables immune evasion by suppressing CD8+ T cells and prevent immune cell infiltration in head and neck cancer. These data demonstrate the relevance of the better understanding of the interaction between HNCSCs and immune cells in the tumor microenvironment. The ultimate clinical implication is to ground the choice of optimized targets and improve immune recognition for ongoing treatments as well as the response to approved immunotherapies.

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Section: Discussionmentioning

confidence: 99%

Section: Hncscs and Escape From The Host Immune Surveillancementioning

confidence: 99%

Mechanisms of immune evasion by head and neck cancer stem cells

Xavier

Silva

Rodini

et al. 2022

Front. Oral. Health

View full text Add to dashboard Cite

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“…By using different phenotype effects, they also take some cells from ovary to study the level of cancer cells present. They want to check out that either they are primarily present there as genetic base or got injected from out through any virus or linked with any other cells [13]. Some promoters are used to stimulate the phenotype effects.…”

Section: Discussionmentioning

confidence: 99%

A Study of Cancer of Ovaries among Women and it’s Linked with the Stem Cells present in Body: A Review

John¹,

Anthony²,

Bhatti³

2022

PJMHS

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Background: Ovarian cancer (OC) is the seventh most commonly diagnosed cancer among women in the world. A woman’s lifetime risk of developing OC is 1 in 75, and her chance of dying of the disease is 1 in 100.Cells which initiate cancer cells in the body are somehow known as stem cells. Objective: The objective of this review was to evaluate the published literature on epidemiologic risk factors for ovarian cancer among women and it’s linked with the stem cells present in the body. Material and methods: A review of literature search was conducted in PubMed and Scopus. Studies comparing ovarian cancer among women and its linked with the stem cells present in the body were included. Results: Eight of 94 articles met the inclusion criteria. The articles revealed that there are no rules to separate out the cells which are spreading tumor cells or in short from this research they said that we are not able to separate them out but we can clarify the issue that either they are spreading this deadly disease or not. Stem cells are not linked with ovarian cancer. Conclusion: It is concluded that phonetically both cancer cells and stem cells are not same. They are showing their opposite impacts. In this study we have seen that first they initiate from a single cell and then start replicating and make groups. There are many other ways through which tumor cells can generate themselves so it is not easy to say that they are growing from stem cells. Keywords: Ovarian cancer, Stem cells and Women

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“…MSCs exert tumor-promoting activity. 50 Moreover, CD90 + CSC-like liver cells-derived CDEs contain lncRNA H19 which enhances the expression of VEGF. 51,52 Similarly CDEs-isolated from OCSCs also facilitated bone marrow MSC migration and enhanced their secretion of VEGF-A, IL-6, and IL-8.…”

Section: Wilczyński Et Al Revealed the Crosstalk Between Cdesderived ...mentioning

confidence: 99%

“…These genes include genes that are related to the promotion of tumor growth, angiogenesis, and cellular migration. Wilczyński et al revealed the crosstalk between CDEs‐derived from ovarian cancer stem cells (OCSCs) and MSCs exert tumor‐promoting activity 50 . Moreover, CD90 + CSC‐like liver cells‐derived CDEs contain lncRNA H19 which enhances the expression of VEGF 51,52 .…”

Section: Role Of Exosome In Csc Communicationmentioning

confidence: 99%

Exosome‐based cancer stem cell communication: Implication for detecting and eliminating cancer stem cells

Dutta

Paul

2022

MedComm – Future Medicine

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Exosomes are bilayered nano-dimensional bio-vesicles shed by all types of cells including transformed malignant cells. They are primarily involved in cell-to-cell communication and resemble the contents of their parental cells. They transport specific contents, like DNA, proteins, and lipids, which is selectively absorbed by proximate and distant cell from the site of their release, conditioning the recipient cells. Cancer stem cells (CSCs) are the root cause behind tumor development, immune evasion, and relapse also produce and secrete large quantities of exosomes that aid and abet CSCs. Interaction of CSCs and neighboring cells occurs through the exosomal exchange of biological materials. Exosomes promote immune evasion, metastasis, and self-renewal within the tumor microenvironment. These properties of exosomes are exploited to detect the presence of malignant cells via noninvasive techniques. These exosomes can be modified to target CSCs.In this review, we highlight the unique role of exosomes in disease progression and how they can be exploited to detect CSCs or be used as a vehicle for medicinal drugs and genetic components to destroy CSCs.Exosome research is still in its inception, in-depth analysis of the components and mechanistic details involved in exosome synthesis and precise bio-engineering for cell-targeting will help us discern it as a nextgeneration cancer therapy option.

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Cancer Stem Cells in Ovarian Cancer—A Source of Tumor Success and a Challenging Target for Novel Therapies

Cited by 32 publications

References 470 publications

Mechanisms of immune evasion by head and neck cancer stem cells

Mechanisms of immune evasion by head and neck cancer stem cells

A Study of Cancer of Ovaries among Women and it’s Linked with the Stem Cells present in Body: A Review

Exosome‐based cancer stem cell communication: Implication for detecting and eliminating cancer stem cells

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