Cancer stem‐like cells in adenoid cystic carcinoma of salivary glands: relationship with morphogenesis of histological variants

Fujita, Shuichi; Ikeda, Tohru

doi:10.1111/j.1600-0714.2011.01096.x

Cited by 14 publications

(14 citation statements)

References 39 publications

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“…CD133 or CD44 has been thought to represent a promising CSC marker and CD133- or CD44-positive cells play an important role in morphogenesis of salivary ACC [25,39]. In this study, we have shown that ectopic expression of c-kit in ACC-M/2 cells increases the CD133 + /CD44 + subpopulation and enhances the mammosphere forming ability, a property of the stem cells.…”

Section: Discussionsupporting

confidence: 52%

“…CD133 and CD44 has been regarded a cancer stem-like cell marker and CD133- or CD44-positive cells play an important role in morphogenesis of ACC[25]. To determine whether c-kit has the effect to lead to the stem cell phenotypes upon induction of EMT, we carried out Fluorescence Activating Cell Sorter (FACS) to identify CD133-positvie or CD44-positive populations.…”

Section: Resultsmentioning

confidence: 99%

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C-kit induces epithelial-mesenchymal transition and contributes to salivary adenoid cystic cancer progression

et al. 2014

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Epithelial–mesenchymal transition (EMT) is associated with salivary adenoid cystic cancer (ACC) progression and metastasis. Here, we report that ectopic overexpression of c-kit in ACC cell lines is sufficient for acquisition of mesenchymal traits, enhanced cell invasion, along with stem cell properties defined by the presence of a CD133 + /CD44 + cell subpopulation. c-kit positively regulated expression of known EMT inducers, also activating TGF-β to contribute to EMT. c-kit itself was induced by TGF-β in ACC cell lines and required for TGF-β–induced EMT. Xenograft experiments showed that c-kit cooperated with oncogenic Ras to promote tumorigenesis in vivo. Finally, in human specimens of ACC, we found that c-kit was abnormally overexpressed and correlated with the prognosis of ACC. Our findings define an important function for c-kit in ACC progression by orchestrating EMT, and they implicate this gene product as a marker of poor prognosis in this disease.

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Section: Discussionsupporting

confidence: 52%

Section: Resultsmentioning

confidence: 99%

C-kit induces epithelial-mesenchymal transition and contributes to salivary adenoid cystic cancer progression

et al. 2014

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“…To date, the possible existence of CSCs has been identified in leukemia [7], breast cancer [8,9], gastric cancer [10], cervical cancer [11], and other malignancies [12,13]. The presence of CSCs in ACC is likely one of the main causes of tumor progression, metastasis, recurrence, and resistance to therapy [14,15]. …”

Section: Introductionmentioning

confidence: 99%

High Expression of SOX2 Is Associated with Poor Prognosis in Patients with Salivary Gland Adenoid Cystic Carcinoma

Dai

Tan

Sun

et al. 2014

IJMS

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Sex determining region Y-BOX2 (SOX2), one of the key members of the SOX family, is a transcription factor that is involved in the maintenance of embryonic stem cell pluripotency and in multiple developmental processes. Recent studies have shown that SOX2 is aberrantly expressed in several types of tumors. The present study aimed to investigate the clinicopathological and prognostic significance of SOX2 in adenoid cystic carcinoma (ACC) of salivary gland. In this study, the expression of SOX2 in ACC tissues and matched adjacent non-cancerous tissues was measured by immunohistochemistry, western blot, and quantitative polymerase chain reaction. High SOX2 expression occurred in approximately 62.6% of primary ACC. In addition, high expression of SOX2 was significantly associated with T classification (p = 0.003) and distant metastasis (p = 0.002). The 5-year overall survival (OS) and disease-free survival (DFS) in patients with high SOX2 expression is poorer than those with low SOX2 expression. When adjusted by multivariate analysis, high SOX2 expression, together with distant metastasis, was an independent prognostic factor. The findings of the present study provide evidence that SOX2 represents a potential novel prognostic biomarker for ACC patients.

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“…Bunların yaklaşık %50'si malign özellikler gösterir. Adenoid kistik karsinom, mukoepidermoid karsinom, polimorfik düşük dereceli adenokarsinom bunlardan en sık görülenleridir 14 .…”

Section: Minör Tükürük Bezi Karsinomlarıunclassified

“…Boyun lenf nodlarına ve akciğerlere metastaz sıklıkla bildirilmiştir. Bu tümörde tedavi yaklaşımı genellikle cerrahi rezeksiyon ve postoperatif radyasyon şeklindedir 14,15 .…”

Section: Adenoid Kistik Karsinomunclassified

Oral Mukozanın Malign Hastalıkları

...

2012

Turkderm

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ÖzetDünyada önemli bir sağlık sorunu olan oral kanser, baş ve boyun kanserlerinin bir alt tipidir. Bu kanserler dünya çapında 6. en sık rastlanan malign tümörlerdir. Ağızdaki tüm malign tümörlerin % 90'ı skuamöz hücreli karsinomdur. Oral skuamöz hücreli karsinomun etyolojisi karmaşıktır. Özellikle gelişmiş ülkelerde en önemli risk faktörleri, sigara ve alkol alımıdır. (Türk derm 2012; 46 Özel Sayı 2: 90-5) Anah tar Ke li me ler: Oral mukoza, oral kanser, skuamöz hücreli karsinom Sum maryOral cancer which is a significant world health problem is a subtype of head and neck cancer. They are the sixth most common malignant tumors worldwide. More than 90% of malignant tumors in the mouth are squamous cell carcinomas. Etiology of the oral squamous cell carcinoma is complex. The most important risk factors, especially in well-developed countries are tobacco smoking and alcohol exposure.. Gi riflOral mukozada gelişen malignitelerin %90'dan fazlasının skuamöz hücreli karsinom (SHK) olduğu belirtilmiştir. Bunun %30'a yakını dudakları etkiler. Ağız içi ve dildeki yerleşim, temas edilen maddelere göre değişiklik gösterir. Ağız içi kanserlerinin çoğunluğu ağız tabanına yerleşse de, yanak mukoza yerleşimi de temasa bağlı olarak sıklıkla bildirilmiştir. Skuamöz Hücreli Karsinom SıklıkOral malignite gelişiminin Hindistan, Fransa, Güney Afrika, Brezilya ve Avustralya gibi ülkelerde sıklıkla arttığı bildirilmiştir 1 . Ülkemizde oral malignite sıklığı ile ilgili bir veri bulunmamakla beraber, dudak mukozası da düşünüldüğünde görülme sıklığının artmakta olduğu söylenebilir. Birinci derece akrabalarında oral SHK görülen kişilerde SHK gelişme sıklığı artmaktadır. EtyopatogenezHastalık etyopatogenezinde ultraviyole radyasyonu (genelde alt dudağı etkiler), sigara, tütün, "betel" (benzopren, nitrozamin) çiğnenmesi, ayrıca oral HPV infeksiyonu, kronik alkol tüketimi, meyve ve sebzelerden fakir diyet, ağız içi hijyen bozukluğu ve diş protezleri risk faktörleridir 1 . Lökoplaki ve eritroplaki gibi oral mukozaya yerleşen bazı premalign hastalıkların SHK gelişme riskini arttırdığı bilinmektedir 1,2 . Bunların dışında oral liken planus, diskoid lupus eritematozus ve submukozal fibrozis riski arttıran hastalıklardır. Farklı çalışmalarda, immün süpresif hastalarda oral SHK sıklığının özellikle gençlerde arttığı gözlenmiştir. Lökoplaki, oral mukozanın en sık rastlanan premalign lezyonu olup, 50 yaş üstü erkeklerde daha sık rastlanır 1,3 . Eritroplaki, lökoplakiden daha az sıklıkta görülmesine rağmen malignite gelişme riski daha fazladır. Oral liken planusun genelde erozif ve ülseratif tiplerinde malign dönüşüm görülebilir (Resim 1). Bu hastalarda oral hijyen bozukluğu, dental işlemler, gıdalar ve sigara kullanımı gibi

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Cancer stem‐like cells in adenoid cystic carcinoma of salivary glands: relationship with morphogenesis of histological variants

Cited by 14 publications

References 39 publications

C-kit induces epithelial-mesenchymal transition and contributes to salivary adenoid cystic cancer progression

C-kit induces epithelial-mesenchymal transition and contributes to salivary adenoid cystic cancer progression

High Expression of SOX2 Is Associated with Poor Prognosis in Patients with Salivary Gland Adenoid Cystic Carcinoma

Oral Mukozanın Malign Hastalıkları

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