Cancer stem-like cells in uveal melanoma: novel insights and therapeutic implications

Loda, Alessandra; Semeraro, Francesco; Parolini, Silvia; Ronca, Roberto; Rezzola, Sara

doi:10.1016/j.bbcan.2024.189104

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

2024

DOI: 10.1016/j.bbcan.2024.189104

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Cancer stem-like cells in uveal melanoma: novel insights and therapeutic implications

Alessandra Loda,

Francesco Semeraro,

Silvia Parolini

et al.

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2024

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Cited by 2 publications

References 110 publications

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Circular RNAs in tumor immunity and immunotherapy

Zhang,

Xu,

Yang

et al. 2024

Mol Cancer

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Circular RNAs (circRNAs) are unique noncoding RNAs that have a closed and stable loop structure generated through backsplicing. Due to their conservation, stability and tissue specificity, circRNAs can potentially be used as diagnostic indicators and therapeutic targets for certain tumors. Many studies have shown that circRNAs can act as microRNA (miRNA) sponges, and engage in interactions with proteins and translation templates to regulate gene expression and signal transduction, thereby participating in the occurrence and development of a variety of malignant tumors. Immunotherapy has revolutionized the treatment of cancer. Early researches have indicated that circRNAs are involved in regulating tumor immune microenvironment and antitumor immunity. CircRNAs may have the potential to be important targets for increasing sensitivity to immunotherapy and expanding the population of patients who benefit from cancer immunotherapy. However, few studies have investigated the correlation between circRNAs and tumor immunity. In this review, we summarize the current researches on circRNAs involved in antitumor immune regulation through different mechanisms and their potential value in increasing immunotherapy efficacy with the goal of providing new targets for cancer immunotherapy.

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Circular RNAs in tumor immunity and immunotherapy

Zhang,

Xu,

Yang

et al. 2024

Mol Cancer

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Advances in immunotherapy for mucosal melanoma: harnessing immune checkpoint inhibitors for improved treatment outcomes

Shan,

Liu

2024

Front. Immunol.

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Mucosal melanoma (MM) poses a significant clinical challenge due to its aggressive nature and limited treatment options. In recent years, immunotherapy has emerged as a promising strategy for MM, with a particular focus on immune checkpoint inhibitors such as PD-1 and CTLA-4 inhibitors. These inhibitors have demonstrated substantial efficacy by harnessing the body’s immune response against tumors. Moreover, adoptive cell transfer (ACT), anti-angiogenic therapy, and combination therapies have garnered attention for their potential in MM treatment. ACT involves modifying T cells to target melanoma cells, showing promising antitumor activity. Anti-angiogenic therapy aims to impede tumor growth by inhibiting angiogenesis, while combination therapies, including immune checkpoint inhibitors and targeted therapies, offer a multifaceted approach to overcome treatment resistance. This comprehensive review explores the advancements in immunotherapy for MM, highlighting the role of diverse therapeutic modalities in enhancing treatment outcomes and addressing the challenges posed by this aggressive malignancy.

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Cancer stem-like cells in uveal melanoma: novel insights and therapeutic implications

Cited by 2 publications

References 110 publications

Circular RNAs in tumor immunity and immunotherapy

Circular RNAs in tumor immunity and immunotherapy

Advances in immunotherapy for mucosal melanoma: harnessing immune checkpoint inhibitors for improved treatment outcomes

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