Cancer survivors exhibit a different relationship between muscle strength and health-related quality of life/fatigue compared to healthy subjects

Morishita, Shinichiro; Tsubaki, Atsuhiro; Fu, Jack B.; Mitobe, Yuta; Onishi, Hideaki; Tsuji, Takao

doi:10.1111/ecc.12856

Cited by 21 publications

(51 citation statements)

References 38 publications

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“…A Japanese study, of which more than 75% of the subjects were female, found no relation between muscle strength and fatigue in comparisons of cancer survivors and healthy participants [6]. A crosssectional study of Latin Americans including mainly elder people (mean age was 76 for the sarcopenic participants and 70 for the participants without sarcopenia) also concluded that sarcopenia and fatigue were not associated [17].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, skeletal muscle mass has been suggested as a factor related to fatigue in cancer patients, although findings on the association between skeletal muscle mass and fatigue have been inconsistent between studies. Some studies have shown strong association between low skeletal muscle mass and fatigue [14,15], whereas other studies have not found any association [6,16,17].…”

Section: Introductionmentioning

confidence: 95%

“…Fatigue is a common and distressing symptom of cancer survivors and may negatively affect healthrelated quality of life of cancer survivors even until several years after completing primary treatment [3][4][5][6]. The National Comprehensive Cancer Network (NCCN) suggested that all cancer patients should be screened for fatigue when they visit a clinic and should receive further evaluation and intervention if the degree of fatigue is moderate to severe [7].…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, studies that found no association between skeletal muscle mass and fatigue were mostly conducted on elderly people or female cancer patients [6,16,17]. However, the association between skeletal muscle mass and fatigue among middle-aged cancer survivors remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Association between fatigue and sarcopenia in middle-aged Korean cancer survivors: A cross-sectional study

Shin¹,

Cho²,

Shin³

et al. 2020

Preprint

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Background Fatigue is a common and distressing symptom of cancer survivors, negatively affecting health-related quality of life. We evaluated the relation between fatigue and low relative skeletal muscle mass in middle-aged cancer survivors. Methods Study participants were 693 Korean cancer survivors aged 40-64 years, who was recruited between September 2014-February 2017 from a cancer survivorship clinic of a university-affiliated hospital. We measured appendicular skeletal muscle mass of study participants with bioelectrical impedance analysis and collected selected variables through a self-administered questionnaire and medical record review. Fatigue was evaluated by a 9-item fatigue severity scale (FSS) which was validated in previous studies. Sarcopenia was defined by appendicular skeletal muscle index cut-off values stratified by sex (< 7.0kg/m2 for males, <5.7kg/m2 for females). Severe fatigue was defined as high FSS score (≥36). The association between sarcopenia and fatigue was assessed using multiple logistic regression analysis. Results Overall, 18.6% of study participants were sarcopenic, 15.0% for males and 20.3% for females. Total scores of FSS (29.3 vs, 23.5, P = 0.034) and prevalence of severe fatigue (FSS≥36) (39.4% vs. 19.3%, P = 0.012) were higher in the sarcopenia group compared with the non-sarcopenia group, distinctively in male cancer survivors. Even after adjusting for selected covariates including cancer related factors and lifestyle factors, sarcopenia was significantly associated with severe fatigue in male survivors (Odd ratio [OR]: 5.36, 95% CI: 1.47, 19.54) and pre-menopausal females (OR: 2.33, 95% CI: 1.06, 5.13). However, the significant association was not found for post-menopausal females (OR: 2.28, 95% CI: 0.77, 6.79). resConclusion Sarcopenia was positively associated with severe fatigue of middle-aged cancer survivors, independent of cancer related factors and lifestyle factors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between fatigue and sarcopenia in middle-aged Korean cancer survivors: A cross-sectional study

Shin¹,

Cho²,

Shin³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Morishita et al. () examine muscle strength in long‐term cancer survivors—and confirm it is an important factor in improving quality of life, reinforcing the need to focus not just on cardiovascular fitness in cancer rehabilitation programmes. Travier et al.…”

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confidence: 99%

Lifestyle factors in cancer survivors-We have the evidence, but are we doing enough?

Weller

2018

Eur J Cancer Care

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Lifestyle factors in cancer survivors-We have the evidence, but are we doing enough? may have little relevance to their patient's circumstances. del Valle, Martín-Payo, Cuesta-Briand, and Lana (2018) examined dietary behaviours in women with breast cancer-they found that a relatively simple intervention (a booklet with or without telephone follow-up) was effective in bringing about sustainable improvements in diet (such as greater consumption of fruit and vegetables and lower fat intake). These findings add to the growing body of evidence that simple, cost-effective lifestyle interventions can bring about dietary changes in patients with cancer-changes which are sustainable well beyond the life of the intervention. Lifestyle interventions in patients with cancer are important, but sometimes neglected. They are often inexpensive and can produce sustainable effects. HCPs and those involved in planning cancer services should ensure that lifestyle is a central consideration in the care for our growing numbers of cancer survivors.

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Association between skeletal muscle mass and quality of life in adults with cancer: a systematic review and meta‐analysis

Hanna

Nguo

Furness

et al. 2022

J cachexia sarcopenia muscle

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Low skeletal muscle mass is known to be associated with poor morbidity and mortality outcomes in cancer, but evidence of its impact on health‐related quality of life (HRQOL) is less established. This systematic review and meta‐analysis was performed to investigate the relationship between skeletal muscle mass and HRQOL in adults with cancer. Five databases (Ovid MEDLINE, Embase via Ovid, CINAHL plus, Scopus, and PsycInfo) were systematically searched from 1 January 2007 until 2 September 2020. Studies reporting on the association between measures of skeletal muscle (mass and/or radiodensity) derived from analysis of computed tomography imaging, and a validated measure of HRQOL in adults with cancer, were considered for inclusion. Studies classifying skeletal muscle mass as a categorical variable (low or normal) were combined in a meta‐analysis to investigate cross‐sectional association with HRQOL. Studies reporting skeletal muscle as a continuous variable were qualitatively synthesized. A total of 14 studies involving 2776 participants were eligible for inclusion. Skeletal muscle mass classified as low or normal was used to dichotomize participants in 10 studies (n = 1375). Five different cut points were used for classification across the 10 studies, with low muscle mass attributed to 58% of participants. Low muscle mass was associated with poorer global HRQOL scores [n = 985 from seven studies, standardized mean difference −0.27, 95% confidence interval (CI) −0.40 to −0.14, P < 0.0001], and poorer physical functioning domain HRQOL scores (n = 507 from five studies, standardized mean difference −0.40, 95% CI −0.74 to −0.05, P = 0.02), but not social, role, emotional, or cognitive functioning domain scores (all P > 0.05). Five studies examined the cross‐sectional relationship between HRQOL and skeletal muscle mass as a continuous variable and found little evidence of an association unless non‐linear analysis was used. Two studies investigated the relationship between longitudinal changes in both skeletal muscle and HRQOL, reporting that an association exists across several HRQOL domains. Low muscle mass may be associated with lower global and physical functioning HRQOL scores in adults with cancer. The interpretation of this relationship is limited by the varied classification of low muscle mass between studies. There is a need for prospective, longitudinal studies examining the interplay between skeletal muscle mass and HRQOL over time, and data should be made accessible to enable reanalysis according to different cut points. Further research is needed to elucidate the causal pathways between these outcomes.

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Cancer survivors exhibit a different relationship between muscle strength and health-related quality of life/fatigue compared to healthy subjects

Cited by 21 publications

References 38 publications

Association between fatigue and sarcopenia in middle-aged Korean cancer survivors: A cross-sectional study

Association between fatigue and sarcopenia in middle-aged Korean cancer survivors: A cross-sectional study

Lifestyle factors in cancer survivors-We have the evidence, but are we doing enough?

Association between skeletal muscle mass and quality of life in adults with cancer: a systematic review and meta‐analysis

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