2021
DOI: 10.1016/j.yexcr.2020.112414
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Cancer/testis antigen LDHC promotes proliferation and metastasis by activating the PI3K/Akt/GSK-3β-signaling pathway and the in lung adenocarcinoma

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Cited by 30 publications
(23 citation statements)
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“…AKT could phosphorylate and inactivate GSK-3b at Ser9 (48,49), which subsequently stabilized Snail protein and finally caused EMT (50,51). Consistently, accumulated evidence revealed that activation of PI3K/AKT/GSK-3b pathway resulted in lung cancer progression (52), hepatocellular carcinoma metastasis (53) and so on. These data suggested that Agrin might exert its prooncogenic function via PI3K/AKT pathway, with GSK-3b as a potential downstream target.…”
Section: Discussionmentioning
confidence: 77%
“…AKT could phosphorylate and inactivate GSK-3b at Ser9 (48,49), which subsequently stabilized Snail protein and finally caused EMT (50,51). Consistently, accumulated evidence revealed that activation of PI3K/AKT/GSK-3b pathway resulted in lung cancer progression (52), hepatocellular carcinoma metastasis (53) and so on. These data suggested that Agrin might exert its prooncogenic function via PI3K/AKT pathway, with GSK-3b as a potential downstream target.…”
Section: Discussionmentioning
confidence: 77%
“…The phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway is hyperactivated or altered in many cancer types (26)(27)(28) and regulates a broad range of cellular processes (29,30). It is well known that Akt can phosphorylate and inhibit GSK-3b activity, subsequently suppressing the GSK-3b-mediated phosphorylation of Snail1 and facilitating its stabilization and nuclear localization, which ultimately promotes EMT widely presenting in a variety of tumors (31)(32)(33)(34)(35)(36). In addition to GSK-3b, PI3K-Akt also activates mTOR, thereby potentiating Snail1 expression in gastric, breast, pancreatic and ovarian cancer (37)(38)(39)(40).…”
Section: Pi3k-akt Pathwaymentioning
confidence: 99%
“…LDH-C was found to be predominantly expressed in the growing testes and spermatozoa ( Rodriguez et al, 2003 ), with no clear relation to cancer pathogenesis. Some reports demonstrated enhanced LDH-C expression in various tumours such as lung, melanoma, kidney, and breast ( Koslowski et al, 2002 ; Kong et al, 2016 ; Hua et al, 2017 ; Chen et al, 2021 ), and being a promising target for cancer therapy ( Thomas et al, 2020 ; Naik and Decock, 2021 ).…”
Section: Introductionmentioning
confidence: 99%