Cancer — the mitochondrial connection

Paul, Manash K.; Mukhopadhyay, A. N.

doi:10.2478/s11756-007-0094-4

Cited by 6 publications

(2 citation statements)

References 71 publications

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“…tumors (Paul and Mukhopadhyay, 2007). Diminished mitochondrial numbers have also been reported in rat hepatic tumor cells (Luciakova and Kuzela, 1992).…”

Section: Discussionmentioning

confidence: 81%

Ultrastructural alterations in liver of mice exposed chronically and transgenerationally to aqueous extract of betel nut: Implications in betel nut‐induced carcinogenesis

Choudhury

Sharan

2009

Microscopy Res & Technique

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The aqueous extract of betel nut (AEBN) induces the formation of preneoplastic nodules in the liver of Swiss Albino mice and leads to increased predisposition to cancer when administered transgenerationally. The aim of this investigation was to elucidate the alterations in ultrastructure of subcellular organelles in the liver nodules using transmission electron microscopy and to determine whether these alterations have implications in AEBN-induced carcinogenesis. Male and female Swiss Albino mice were exposed to AEBN chronically and transgenerationally at a dose of 2 mg/mL in drinking water for 24 weeks. Extensive polymorphism was noted in nuclear shape and heterochromatin organization. Heterochromatin aggregation and marginalization were observed in the nuclei of chronically exposed mice, whereas transgenerationally exposed mice exhibited dispersion or loss of heterochromatin. The nuclear envelope was disrupted, and the nucleoli were enlarged in chronically exposed mice, whereas in transgenerationally exposed mice the nucleoli were reduced in size or totally absent. The cisternae of the rough endoplasmic reticulum were dilated and disrupted, and a large number of autophagic vesicles were observed in both chronically and transgenerationally exposed mice. Atypical mitochondria that underwent extensive cristolysis and progressively declined in size and number from the chronically exposed mice to the different generations of transgenerationally exposed mice were also observed. Thus, exposure to AEBN resulted in severe loss of ultrastructural integrity of cells in the liver nodules, and the progressive loss of mitochondrial function appeared to play a significant role in increasing the predisposition to cancer of mice exposed transgenerationally to AEBN.

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“…tumors (Paul and Mukhopadhyay, 2007). Diminished mitochondrial numbers have also been reported in rat hepatic tumor cells (Luciakova and Kuzela, 1992).…”

Section: Discussionmentioning

confidence: 81%

Ultrastructural alterations in liver of mice exposed chronically and transgenerationally to aqueous extract of betel nut: Implications in betel nut‐induced carcinogenesis

Choudhury

Sharan

2009

Microscopy Res & Technique

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“…It was noticeable that the dexamethasone-induced skeletal muscle atrophy was companied with the mitochondria swell in chicks. Mitochondria are the powerhouse of the cell and play a vital role in the energy metabolism and apoptosis (Paul & Mukhopadhyay 2007). Azad et al (2010) showed that chronic heat stress increased oxygen consumption rate and ROS (reactive oxygen species) production in skeletal muscle mitochondria of broiler chicken.…”

Section: Discussionmentioning

confidence: 99%

Effect of insulin on dexamethasone-induced ultrastructural changes in skeletal and cardiac muscle

Qin

Yang

et al. 2012

Biologia

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Glucocorticoids help animals respond to stressors but excessive glucocorticoids cause muscle atrophy, while insulin can promote anabolism and growth. In order to compare the glucocorticoids-induced ultrastructural changes between skeletal muscle and cardiac muscle, and investigate the preventive effects of insulin on the changes, eighteen male chicks with similar initial weight were randomly divided into three groups. The two test groups were respectively treated with high-dose dexamethasone alone or together with low-dose insulin by intraperitoneal injection, and the control group was treated with an equal volume of saline solution. The experiment lasted for ten days, and then the body weight, muscle size and ultrastructure in skeletal and cardiac muscles of twelve chicks were qualitatively or quantitatively analyzed. The results showed that high-dose dexamethasone induced obvious skeletal and cardiac muscle atrophy. The differences of ultrastructural changes between skeletal muscle and cardiac muscle (such as for the former or the latter, the intermyofibrillar-and-interfilamentary spaces reducing or enlarging, the mitochondria swelling seriously or enlarging lightly, the myofibril filaments compacting or loosing) suggested that dexamethasone induced skeletal and cardiac muscle atrophy by different mechanisms. Low-dose insulin did not affect the dexamethasone-induced decreases of body weight and skeletal muscle size, but alleviated lightly the dexamethasone-induced ultrastructural changes in skeletal muscle. Different from skeletal muscle, low-dose insulin almost resisted the dexamethasone-induced ultrastructural changes in cardiac muscle.

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Caloric Restriction and Oxidative Stress

Škrha

2011

Oxidative Stress in Vertebrates and Invertebrates

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Cancer — the mitochondrial connection

Cited by 6 publications

References 71 publications

Ultrastructural alterations in liver of mice exposed chronically and transgenerationally to aqueous extract of betel nut: Implications in betel nut‐induced carcinogenesis

Ultrastructural alterations in liver of mice exposed chronically and transgenerationally to aqueous extract of betel nut: Implications in betel nut‐induced carcinogenesis

Effect of insulin on dexamethasone-induced ultrastructural changes in skeletal and cardiac muscle

Caloric Restriction and Oxidative Stress

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