Cancer Therapy: Giant Magnetic Heat Induction of Magnesium‐Doped γ‐Fe₂O₃ Superparamagnetic Nanoparticles for Completely Killing Tumors (Adv. Mater. 6/2018)

Abstract

Magnesium‐doped g‐Fe2O3 superparamagnetic nanoparticles with exceptionally high intrinsic loss power of 14 nH m2 kg−1, which is ≈100 times higher than that of commercial Fe3O4, at a physiologically safe range of AC magnetic field (Happlfappl = 1.23 × 109 A m−1 s−1) are developed by Seongtae Bae and co‐workers in article number https://doi.org/10.1002/adma.201704362. Their hyperthermia effect is revealed to be promising for completely killing tumors.

Cell Membrane‐Coated Magnetic Nanocubes with a Homotypic Targeting Ability Increase Intracellular Temperature due to ROS Scavenging and Act as a Versatile Theranostic System for Glioblastoma Multiforme

“…It has to be noted that the best results were acquired when an AMF of 20 mT at 750 KHz and a 9 turn-44 mm coil were used, and for these parameters the highest obtained SAR and ILP values were 78.6 ± 3.9 W g -1 and 0.40 ± 0.02 nHm 2 kg -1 , respectively, values that are higher with respect to commercial Fe 3 O 4 nanoparticles reported in the literature. [21] It has to be mentioned that high values of SAR (49.6 ± 2.4 W g -1 ) and ILP (0.80 ± 0.04 nHm 2 kg -1 ) were also obtained using a 56 mm coil and 12 mT at 657 KHz of AMF, values close to the Brezovich limit (4.85 × 108 A m -1 s -1 ). [22] Nevertheless, for the in vitro evaluation of the CM-NCubes we have decided to use the maximum possible magnetic field and frequency, in order to overcome the limited heating efficiency.…”

Spatial Homogeneity of Superparamagnetic Nanoparticles and the Relationship to Relaxivity for Magnetic Resonance Imaging

“…Controlled by D h and PDI on the r 2 -Relaxivity. According to our previous works, 20,33,40 iron oxide-based MNPs have superparamagnetic phase around d MNP = 9−10 nm with almost the same M as bulk, but they have mixed ferromagnetic and ferromagnetic phases at the d MNP > 10 nm depending on the particle size. Considering this research result and the coating layer thickness (approximately 2−3 nm, Figure 1d and Figure S3 (Supporting Information)) of O.A./methoxy-PEG-silane along with a typical hydration layer between the coating layer and the surface of the four SPIONPs, the D h of the coated SPIONPs in nanofluids would be theoretically assumed to be 16 nm < D h < 27 nm with ±15.6%.…”

“…By systematically plotting and fitting the T 2 curve as a function of σ (spatial homogeneity of nanofluids), the physical relationship between T 2 relaxation time (1/r 2 ) and σ was fundamentally interpreted and compared to the changed behavior of the experimentally obtained T 2 relaxation time (r 2 -relaxivity). 20,33,34 Because the DC magnetic property, particularly m(M), is critical for the r 2 -relaxivity, the DC M-H loops of the solid-state MNPs were characterized using a VSM. As shown in Figure S1 (Supporting Information), all four solid-state MNPs had typical superparamagnetic characteristics and a similar saturated magnetization M (65 ± 5 emu/g) at the sweeping field of ±15 kOe.…”

“…4 )-γFe 2 O 3 , and (Ni 0.75 Zn 0.25 )-γFe 2 O 3 , to enhance the m(M). 33,34 For comparison, typical Fe 3 O 4 SPIONPs were also synthesized using the same synthesis method. The surface of shallowly doped γ-Fe 2 O 3 SPIONPs was modified using a thin intermediate O.A.…”

Co3O4-γ-Fe2O3Nanocrystal Heterostructures with Enhanced Coercivity and Blocking Temperature

“…Synthesis and magnetic properties of FM-AFM nanoscale heterostructures have been of interest in the field of physical chemistry. , We chose γ-Fe 2 O 3 and Co 3 O 4 nanoparticles for creating this network as these have been potential materials for applications in magnetic data storage devices, color imaging, magnetic resonance image enhancement, biomedicine, and catalysis − ,− and possess unique electronic and magnetic characteristics such as macroscopic quantum tunnelling associated with size quantization and electronic quantum confinement effects.…”