Cancer therapy related complications in the liver, pancreas, and biliary system: an imaging perspective

Ngo, Danny; Jia, Jemianne Bautista; Green, Christopher S.; Gulati, Anjalie T.; Lall, Chandana

doi:10.1007/s13244-015-0436-7

Cited by 25 publications

(21 citation statements)

References 67 publications

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“…No particular chemotherapeutic agent has been identified as sole culprit. Several agents, including capecitabine, gemcitabine, trastuzumab and paclitaxel, have been associated with pseudocirrhosis [ 4 , 12 ]. No clinical significance between capsular retraction and chemotherapeutic regimen or hormone-receptor status was found in a retrospective review of 29 patients with breast cancer with hepatic metastasis [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Pseudocirrhosis: A Case Series and Literature Review

Adike

Karlin

Menias

et al. 2016

Case Rep Gastroenterol

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Pseudocirrhosis describes morphological changes of the liver that closely mimic cirrhosis, without the typical histopathological changes seen in cirrhosis. It most commonly occurs in patients with metastatic breast cancer, although it has been reported in other malignancies as well. Like in cirrhosis, portal hypertension is often seen in patients with pseudocirrhosis. Pseudocirrhosis is a rare but important complication of metastatic cancer. In this case series and literature review, we describe 6 patients with hormone-receptor-positive metastatic breast cancer. We report the significant morbidity associated with pseudocirrhosis in the course of treatment in patients with metastatic breast cancer.

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Section: Discussionmentioning

confidence: 99%

Pseudocirrhosis: A Case Series and Literature Review

Adike

Karlin

Menias

et al. 2016

Case Rep Gastroenterol

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“…Due to the development of chemotherapy resistance, numerous phytochemical compounds derived from edible plants and their synthetic derivatives have attracted attention due to their unique anticancer properties and have been recommended for cancer therapy ( 31 – 33 ). However, information focusing on the anticancer properties of phytochemical compounds is limited; therefore, it is necessary to elucidate the mechanisms underlying their antitumor effects ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines

et al. 2018

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It is widely accepted that apoptosis is closely associated with cancer cell death. However, whether autophagy induces tumor cell death has not been fully elucidated. Various studies have discussed the antitumor properties of rottlerin in human malignancies. The current study aimed to investigate the effects of rottlerin, a natural product isolated from the kamala tree (Mallotus philipensis), on growth inhibition and autophagy in gastric cancer (GC) cell lines in vitro. The results of the present study demonstrated that rottlerin suppressed cell growth, induced autophagy and apoptosis, and reduced migration and invasion in the SGC-7901 and MGC-803 GC cell lines. Furthermore, rottlerin led to microtubule-associated protein 1 light chain 3β-II augmentation and the enrichment of autophagosomes. In addition, the protein expression levels of mechanistic target of rapamycin kinase and S-phase kinase-associated protein 2 were downregulated in GC cells following rottlerin treatment, which is associated with autophagy. The protein levels of caspase-3, cleaved-caspase-3, total poly (ADP-ribose) polymerase (PARP) and cleaved-PARP exhibited no marked alterations in the GC cells following rottlerin treatment, indicating that caspases were likely not involved in rottlerin-induced GC apoptosis. In summary, the results of the present study indicate that rottlerin may inhibit invasion and promote apoptosis in GC cells, which may be mediated by the activation of autophagy. Therefore, rottlerin may be of value in the treatment of GC.

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“…However, a more complicated scenario may also arise such as hepatic abscess, spontaneous bacteria peritonitis, sepsis, tumour rupture and even generalised hepatic ischaemia 32. Furthermore, sunitinib has been associated with bleeding, pancreatitis, hepatic complications including inflammation and abscess (due to hepatic clearance) and acalculous cholecystitis 33. The patient described in the current report presented with positive blood cultures for S treptococcus and findings on CT concerning for a hepatic abscess, and sunitinib may have contributed to the clinical picture.…”

Section: Discussionmentioning

confidence: 99%

Solid pseudopapillary tumour (Frantz’s tumour) of the pancreas in childhood: successful management of late liver metastases with sunitinib and chemoembolisation

Escobar¹,

McClellan

Thomas

2017

BMJ Case Reports

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The patient is a girl aged 17 years who originally presented at age 11 years with a solid pseudopapillary tumour (SPT) in the head of the pancreas treated by an R0 pylorus-preserving Whipple procedure. The patient underwent surveillance CT every 3 months for the first year followed by MRI every 6 months. She was noted to have a new liver lesion in Couinaud segment VI highly suspicious for metastasis at 30 months. Liver wedge biopsy confirmed metastatic SPT. Two months later two new lesions were noted in Couinaud segment VII. The family preferred medical management to surgery resulting in a treatment combination of the tyrosine kinase inhibitor sunitinib and hepatic artery embolisation. The patient developed a hepatic abscess following embolisation but recovered with antibiotics. The patient has subsequently been followed with serial MRIs every 3 months, and 20 months following chemoembolisation, she has no evidence of recurrence of the metastases.

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Cancer therapy related complications in the liver, pancreas, and biliary system: an imaging perspective

Cited by 25 publications

References 67 publications

Pseudocirrhosis: A Case Series and Literature Review

Pseudocirrhosis: A Case Series and Literature Review

Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines

Solid pseudopapillary tumour (Frantz’s tumour) of the pancreas in childhood: successful management of late liver metastases with sunitinib and chemoembolisation

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