Cancer Treatment Side Effects: A Meta-analysis of the Relationship Between Response Expectancies and Experience

E, Devlin; Denson, Linley A.; Whitford, Hayley S.

doi:10.1016/j.jpainsymman.2017.03.017

Cited by 77 publications

(59 citation statements)

References 63 publications

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“…In keeping with these results, a number of longitudinal studies have examined how prospective patient expectations are related to later experience of side effects and QOL in cancer survivors. Often referred to as response expectancies, these have been shown to have associations with actual experience of side effects in that, when certain side effects are expected, they are more likely to be later reported . This has been termed the “nocebo” effect and is considered a neurobiological problem influenced by the way in which information is presented to patients .…”

Section: Discussionmentioning

confidence: 99%

“…Often referred to as response expectancies, these have been shown to have associations with actual experience of side effects in that, when certain side effects are expected, they are more likely to be later reported. 20,21,29,30 This has been termed the "nocebo" effect and is considered a neurobiological problem influenced by the way in which information is presented to patients. 31 The nocebo effect has also been demonstrated in prostate cancer 32 where pre-treatment expectations were associated with QOL following RP or radiotherapy.…”

Section: The Importance Of Appraisals and Expectationsmentioning

confidence: 99%

“…Survivors also make retrospective appraisals of their illness and treatment, and these too could influence wellbeing . In a recent meta‐analysis, survivors' expectations of side effects, or Response Expectancies, were found to be related to later experience post‐treatment. In prostate cancer, many patients have unrealistic expectations of side effects .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Expecting the worst? The relationship between retrospective and prospective appraisals of illness on quality of life in prostate cancer survivors

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: The Importance Of Appraisals and Expectationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expecting the worst? The relationship between retrospective and prospective appraisals of illness on quality of life in prostate cancer survivors

et al. 2018

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“…The cytotoxic drugs used in chemotherapy cause diverse adverse effects that include nausea and vomiting (NV), diarrhea, anorexia, and weight loss (Hofman et al, 2004;Devlin et al, 2017). These chemotherapy-induced side effects often interrupt drug treatment and negatively impact outcome of the therapy (Andreyev et al, 1998;Hess et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Parapheromones Suppress Chemotherapy Side Effects

Lee

Yang

Kim

et al. 2018

J Pharmacol Exp Ther

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The cytotoxic drugs used in chemotherapy are often accompanied by nausea and vomiting. Despite the use of antiemetic drugs, chemotherapy-induced nausea and vomiting (CINV) remain significant side effects for cancer patients and are associated with serotonin type 3 receptor (5-HTR) activation in the brainstem. Farnesol and nerolidol are sesquiterpene alcohols found in essential oils of plants such as roses, citronella, and lemon grass and are used as antiemetic parapheromones. Medicinal plants often are effective in treating gastrointestinal disorders, including CINV, although the mechanism of action remains unclear. In the current work, the antiemetic efficacy of the naturally occurring racemic mixture of farnesol (-farnesol) and nerolidol (-nerolidol) against cisplatin CINV was tested using the pica behavior (consumption of nonnutritive substances) of rats. Animals treated with -farnesol or-nerolidol consumed a smaller amount of kaolin than of saline-treated control animals. This result is consistent with the antiemetic efficacy of farnesol and nerolidol. Compared with controls, -farnesol- but not-nerolidol-treated animals consumed more food and lost less body weight. Thus, farnesol effectively reduced appetite suppression and weight loss induced by cisplatin. In separate experiments, isomers of farnesol and nerolidol were tested on 5-HT-induced responses of acutely isolated nodose neurons using patch-clamp methods. All the tested constituents inhibited 5-HTR-mediated current in a noncompetitive manner. Thus, both farnesol and nerolidol may exert antiemetic efficacy by inhibiting 5-HT signaling in cranial visceral afferents, resulting in interruption of emetogenic signaling; however, nerolidol failed to suppress cisplatin-induced anorexia and weight loss, suggesting that additional mechanisms may contribute.

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“…reactions, bone marrow suppression, and immunosuppression, leukopenia due to the toxicity of anti-cancer drugs accounts for a significant proportion of secondary leukopenia [10]. The major secondary cause of leukopenia is bone marrow suppression caused by anti-tumor drugs [11].…”

Section: Introductionmentioning

confidence: 99%

Examination of the cellular mechanisms of leukocyte elevation by 10.6 μm and 650 nm laser acupuncture-moxibustion

et al. 2018

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To investigate the cell cycle and cellular mechanisms of leukocyte elevation by laser acupuncture in rats with cyclophosphamide (CTX)-induced leukopenia. Sixty-six rats were randomized into six groups: normal, model control group, sham treatment group, 10.6 μm laser treatment group, 650 nm laser treatment group, and 10.6 μm-650 nm compound laser treatment group. Eleven rats were used in the normal group and 55 were models that were injected with cyclophosphamide to induce leukopenia. For the three laser treatment groups, 10.6-μm and 650-nm lasers, and 10.6-μm-650-nm compound lasers were used to irradiate the DU14 (Dazhui) and bilateral ST36 (Zusanli) for 5 min each. The sham laser group received the same operation as the laser group but without irradiation. The normal group and model group were not treated. Differences in the number of nucleated cells in the femoral bone marrow, and cell cycle and cellular apoptosis of peripheral leukocytes in rats in various groups were compared. Compared with the model group and the sham laser group, the number of nucleated cells in the femoral bone marrow in the 10.6-μm laser, 650-nm laser, and 10.6-μm-650-nm compound laser group was significantly increased after treatment (P = 0.001, 0.002, 0.034, respectively) and did not show any significant difference with the normal group (P = 0.964, P = 0.838, P = 0.287, respectively). The number of cells in G2 phase in the 10.6 μm laser group was similar to that of the normal group (P = 0.973). The number of cells in G2 phase in the model, sham, 650-nm laser group, and 10.6-μm-650-nm compound laser group were significantly lower than in the normal group and 10.6-μm laser group (P = 0.016, P = 0.023, P = 0.044, P = 0.039, respectively). In the model group and the sham treatment group, the apoptosis rates of peripheral leukocytes were increased compared with the normal group (P = 0.001), while the proportion of cells in the G2 phase was significantly lower than in the normal group (P = 0.016), and the proportion of cells in S phase was higher than in the normal group (P = 0.014). The incidence of apoptosis in peripheral blood cells in the three laser treatment groups did not show any statistically significant difference when compared with the normal group (P > 0.05). Treatment with the 10.6-μm, 650-nm, and 10.6-μm-650-nm compound lasers increased the number of nucleated cells in the bone marrow, decreased the unfavorable effects of cyclophosphamide on the cell cycle, induced the cell cycle towards proliferation, decreased apoptosis, improved the intramedullary hematopoietic system, and increased peripheral leukocyte count.

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Cancer Treatment Side Effects: A Meta-analysis of the Relationship Between Response Expectancies and Experience

Cited by 77 publications

References 63 publications

Expecting the worst? The relationship between retrospective and prospective appraisals of illness on quality of life in prostate cancer survivors

Expecting the worst? The relationship between retrospective and prospective appraisals of illness on quality of life in prostate cancer survivors

Parapheromones Suppress Chemotherapy Side Effects

Examination of the cellular mechanisms of leukocyte elevation by 10.6 μm and 650 nm laser acupuncture-moxibustion

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