Cancer vaccines: on the threshold of success

Emens, Leisha A.

doi:10.1517/14728214.13.2.295

Cited by 69 publications

(46 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Host immune response is important for resistance to many types of cancer, including breast, and new cancer therapies that activate an immune response are in development [37,38]. Because d-limonene has demonstrated immune-modulating effects specific to macrophage activation, it is important to determine whether this mechanism could explain d-limonene's effectiveness in pre-clinical mammary cancer models.…”

Section: Mechanisms Of Chemopreventive Activity Of D-limonenementioning

confidence: 99%

d-Limonene: a bioactive food component from citrus and evidence for a potential role in breast cancer prevention and treatment

et al. 2010

View full text Add to dashboard Cite

Although limited, observations from cell culture, animal, and epidemiological studies support the presence of anti-cancer properties in citrus peel and the primary bioactive food constituent, d-limonene. Early evidence from animal models suggests that when ingested, d-limonene exhibits a wide spectrum of biologic activity including chemotherapeutic and chemopreventive effects. In some of these early models, an analog of d-limonene, perillyl alcohol, demonstrated a more potent effect than d-limonene itself. Yet, when perillyl alcohol advanced to clinical trials, several trials were ended early due to doselimiting toxicities. Alternatively, oral d-limonene administration in humans is well tolerated even at high doses supporting its investigation as a potential bioactive for cancer prevention. Though the exact mechanisms of action of d-limonene are unclear, immune modulation and antiproliferative effects are commonly reported. Here, we review the pre-clinical evidence for d-limonene's anticancer mechanisms, bioavailability, and safety, as well as the evidence for anti-cancer effects in humans, focusing on studies relevant to its use in the prevention and treatment of breast cancer.

show abstract

Section: Mechanisms Of Chemopreventive Activity Of D-limonenementioning

confidence: 99%

d-Limonene: a bioactive food component from citrus and evidence for a potential role in breast cancer prevention and treatment

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Therapeutic cancer vaccines amplify or induce an active immune response specific to tumors; immunotherapy can help (1) evade drug resistance caused by signal-transduction pathways in tumor cells, (2) escape unexpected side effects for high specificity, and (3) continue therapeutic efficacy by immune memory [1]. Thus, the potential benefits of therapeutic cancer vaccines stem from their new mechanisms of action.…”

Section: Introductionmentioning

confidence: 99%

Approaches to improve development methods for therapeutic cancer vaccines

Ogi¹,

Aruga²

2015

Immunology Letters

View full text Add to dashboard Cite

“…Success is highly subjective and success to one is not the same to all, as noted by Krakovsky [27], success is an extremely hard concept to research. Success is context based, so can differ when talking about success in engineering to success and success in trialling a new pharmaceutical drug [28,29].…”

Section: School -Social Exclusionmentioning

confidence: 99%

The School’s Role in Creating Successful and Unsuccessful Dyslexics

Alexander-Passe¹

2016

J Psychol Psychother

View full text Add to dashboard Cite

IntroductionThis paper researches the experience of dyslexics at school and how these experiences can either positively drive them to success or negatively drive them into helplessness and possibly crime.The nature vs nurture argument has a long history; from John Locke [1] in 1690 arguing that humans begin in a 'blank state' and that we are the product of our environment and experiences. Of course Darwin [2] and Galton [3] should not be discounted in this discussion, and this argument is summarized in Pinker [4]. Locke, Darwin and more modern thinkers have argued that we are the product of our environment, and all human experiences are placed into the mixing pot to create the individuals we are today. Thus in the case of dyslexics, who experience 10 or more years of hardship at school, where learning in classrooms is not differentiated to their needs, and by teachers that do not recognise they have different learning needs and requirements.It is argued that some teachers have perceived un-identified dyslexic children as 'lazy and 'stupid' through: (1) a lack of dyslexia/ SEN awareness; (2) a lack of understanding of dyslexia/SEN; and (3) a lack of training to identify and differentiate to engage all learners in their classrooms, creating a lack of educational opportunity. If success breeds success, then failure must also breed failure, thus it is argued:• Successful dyslexics are a product of using failure in a positive way (resilience) and more success reinforces this positivity• Unsuccessful dyslexics are a product of using failure in a negative way (learned helplessness) and more failure reinforces this negativity Literature ReviewThis paper uses a broad empirical review to introduce the reader to different aspects of a dyslexics journey through education and in the workplace, and theories to understand their post-school experience. Sections include: dyslexia, school experience/emotional coping in dyslexics, social exclusion, defining success, successful dyslexics, unsuccessful dyslexics, the disability paradox, dyslexia and depression/ mental health, and post-traumatic growth. Elliot and Grigorenko's [6] recent influential but controversial review of literature argued that the term dyslexia poorly defines a condition that affects not only reading, writing, spelling, but also short-term memory, balance, organisation, visual difficulties. There are also difficultly with no single model of diagnosis, with diagnosis Abstract Introduction: This paper investigates school-based trauma and the life-long post-school effects of such trauma, creating successful/unsuccessful individuals in society.

show abstract

Cancer vaccines: on the threshold of success

Cited by 69 publications

References 108 publications

d-Limonene: a bioactive food component from citrus and evidence for a potential role in breast cancer prevention and treatment

d-Limonene: a bioactive food component from citrus and evidence for a potential role in breast cancer prevention and treatment

Approaches to improve development methods for therapeutic cancer vaccines

The School’s Role in Creating Successful and Unsuccessful Dyslexics

Contact Info

Product

Resources

About