CancerPPD: a database of anticancer peptides and proteins

Abstract

CancerPPD (http://crdd.osdd.net/raghava/cancerppd/) is a repository of experimentally verified anticancer peptides (ACPs) and anticancer proteins. Data were manually collected from published research articles, patents and from other databases. The current release of CancerPPD consists of 3491 ACP and 121 anticancer protein entries. Each entry provides comprehensive information related to a peptide like its source of origin, nature of the peptide, anticancer activity, N- and C-terminal modifications, conformation, etc. Additionally, CancerPPD provides the information of around 249 types of cancer cell lines and 16 different assays used for testing the ACPs. In addition to natural peptides, CancerPPD contains peptides having non-natural, chemically modified residues and D-amino acids. Besides this primary information, CancerPPD stores predicted tertiary structures as well as peptide sequences in SMILES format. Tertiary structures of peptides were predicted using the state-of-art method, PEPstr and secondary structural states were assigned using DSSP. In order to assist users, a number of web-based tools have been integrated, these include keyword search, data browsing, sequence and structural similarity search. We believe that CancerPPD will be very useful in designing peptide-based anticancer therapeutics.

Solid-binding peptides: smart tools for nanobiotechnology

“…Online databases are currently available for specific classes of bioactive peptides (e.g., anticancer peptides [68] and antimicrobial peptides [69]) and offer details on their characteristics and properties. Although some SBPs have been deposited into databases that contain a broad range of peptides (e.g., the MimoDB 2.0 database [70]), there is no specialised depository for SBPs.…”

Bioactive Peptides from Legumes as Anticancer Therapeutic Agents

“…This database includes information on sequence, structures, and action mechanisms, depending on the structure, length, hydrophobicity and specific characteristics of each peptide. Then, this database can be useful to design, find and report new peptides and proteins with anticancer activity [57]. Most of the anticancer peptides that are active against tumor cells adopt either a bioactive helical conformation at the cell surface or a β-sheet structure prior to engaging the membrane (Figure 2).…”

Current situation and future usage of anticancer drug databases

“…CancerPPD [27] is a resource of experimentally validated anticancer peptides (ACPs) and proteins. Up to now, the number of total peptide entries, cell lines and total tissue types are 3491, 249 and 21, respectively.…”