Cancers colorectaux en Martinique: incidence et mortalité durant une période de 20 ans

Ngasseu, P.; Dieye, Moustapha; Véronique-Baudin, Jacqueline; Draganescu, C.; Dorival, M.-J.; Ossondo, Marlène; Smith-Ravin, Juliette; Azaloux, H

doi:10.1016/j.respe.2007.06.001

Cited by 7 publications

(7 citation statements)

References 18 publications

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“…In accordance with this latter result, Dieye et al [11] report that, among the 138 Guadeloupian patients recruited in 2008 (cancer registry data), 58.9% were males and 41.1% females, and that distal colon cancers were more frequent. Also, the data of Dieye et al [11,14] and Ngasseu et al [13] confirm our results obtained with the MqueTH patients.…”

Section: Discussionsupporting

confidence: 91%

“…Nevertheless, there are little data regarding the patterns of CRC, particularly in Guadeloupe. As far as we know, there are only three studies which have been published on this topic: one of Serra et al [12] on the comparison of cancer morbidity between Guadeloupe, Martinique and French metropolitan regions; one of Ngasseu et al [13] on CRC incidence and mortality rates in Martinique, and, finally, the study of Dieye et al [14] on epidemiological cancer transition in Martinique.…”

Section: Introductionmentioning

confidence: 99%

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Colorectal cancer in patients seen at the teaching hospitals of Guadeloupe and Martinique: discrepancies, similarities in clinicopathological features, and p53 status

et al. 2014

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BackgroundIn Guadeloupe and Martinique, two French Overseas Departments, colorectal cancer (CRC) has become an essential public health issue. However, little is known about CRC characteristics and the p53 status in these populations, particularly in Guadeloupe, whereas certification of a cancer registry has been recently validated.MethodsThis was a descriptive retrospective study of 201 patients who, between 1995 and 2000, underwent surgery for CRC in the Guadeloupe Teaching Hospital (GlpeTH; 83 patients) and in the Martinique Teaching Hospital (MqueTH; 118 patients). The clinicopathological features and the p53 expression, evaluated with immunohistochemistry, were compared at the time of diagnosis. A relationship between these parameters and the p53 expression was also studied. Data were analysed, using the SPSS computer software version 17.0.ResultsNo statistical difference was found between the two groups of patients regarding age (p = 0.60), percentage of young patients (≤50 years; p = 0.94)), sex (p = 0.47), histological type (p = 0.073) and tumour sites (p = 0.65), although the GlpeTH patients were diagnosed with more distal colon cancers (54.2%) than the Mque TH patients (47.4%). By contrast, a significant difference was found regarding the tumour grade (p < 0.0001), the pTNM stage (p = 0.045) and the pT stage (p < 0.0001). Regarding p53 expression, solely for the MqueTH patients, nuclear expression was associated with pTNM, the percentage of p53 negative tumours increasing with the progression of the pTNM stages (p = 0.029).ConclusionsFor the first time, this study reveals discrepancies in clinicopathological features and in the p53 status between the two groups of patients. The GlpeTH patients were diagnosed with more moderated CRCs but with few CRCs at pTNM IV stage. By contrast, the MqueTH patients were diagnosed with more differentiated tumours, but with many more CRCs at pTNM IV stage. This paradox may be due to differences in tumour location (distal vs proximal), multiplicity of the genetic profiles of patients, or patients getting treatment elsewhere. Although our study is limited due to its small size, it emphasizes the originality of our results.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Colorectal cancer in patients seen at the teaching hospitals of Guadeloupe and Martinique: discrepancies, similarities in clinicopathological features, and p53 status

et al. 2014

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“…Colorectal cancer (CRC) ranks second in the world after breast cancer (22.9%) and before cervical cancer (8.8%) with an incidence of 571,204 new cases per year or 9.4% [ 1 , 2 ]. In the United States, colorectal cancer is the third most common cancer and the second most deadly [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the United States, colorectal cancer is the third most common cancer and the second most deadly [ 3 ]. The incidence of colorectal cancer has increased over the last few decades, with rates varying from one country to another [ 2 , 4 , 5 ]: High risk areas: Australian countries, North America, Western European countries, Japan. Intermediate risk areas: Eastern and Northern European countries.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology, incidence and treatment of rectal cancer in young women case serie about 11 cases (case series)

Hajri

Fatine²,

Eddaoudi³

et al. 2022

Annals of Medicine &Amp; Surgery

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“…It includes all malignant tumors that develop in the portion of the large intestine located between the ileocecal valve and the rectosigmoid junction. The frequency of colon cancer is high in most highincome countries where it constitutes a major public health problem, with an incidence of 1.4 million new cases per year worldwide, which represents approximately 15% of all cancers [1,2]. In France, it ranks first in cancer pathologies and represents nearly 15% of all cancers [1].…”

Section: Introductionmentioning

confidence: 99%

Left-Sided Colon Cancer and Right-Sided Colon Cancer: Are They the Same Cancer or Two Different Entities?

Idrissi¹,

Bouhaddouti²,

Mouaqit³

et al. 2023

Cureus

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BackgroundColon cancer is one of the most common cancers in the world and one of the main causes of cancer-related deaths. In Morocco, it occupies the first place among digestive cancers. Right-sided and left-sided colon cancers have different embryological, epidemiological, pathological, genetic, and clinical characteristics. This distinction leads to differences in the evolution and prognosis of the disease. This study aimed to identify epidemiological factors and clinical and pathological characteristics that can influence perioperative and prognostic outcomes in patients with right-sided colon cancer compared to those with left-sided colon cancer. MethodologyWe conducted a retrospective cohort study over a period of nine years from January 2012 until December 2020. We included 277 patients divided into two groups, namely, right colon cancer (group 1) (n = 99) and left colon cancer (group 2) (n = 178). ResultsThe average age of our series was 57.4 years, with extremes ranging from 19 to 89 years old (SD = ±13.6451 years). The average age in the right colon group was 55.97 (SD = ±13.341 years). The average age in the left colon group was 58.18 (SD = ±13.69 years). The male gender had a predominance, with a sex ratio of 1.3 for both groups. Among the patients in group 2, 65% showed lymph node involvement on the CT scan, whereas only 34% of patients in group 1 displayed the same condition. The recurrence rate in the right-sided colon cancer group was 22.2% compared to 24.9% in the left-sided group. The five-year overall survival was estimated for the right-sided and left-sided colon cancer groups at 87% and 96.5%, respectively. In patients with stage III and IV cancer, overall survival was better for those who underwent surgery for left-sided colon cancer compared to those who underwent surgery for right-sided colon cancer (p = 0.029). In the case of vascular emboli or involvement of the perineural sheath, there was no significant difference in overall survival (p = 0.446 and p = 0.655, respectively). The three-month survival without recurrence was almost identical in both groups (31% for right-sided colon cancers and 30.9% for left-sided colon cancers). Age over 61 years was a predictive factor of poor prognosis in recurrence-free survival (hazard ratio = 3.245; p = 0.023). ConclusionsWe identified factors that can influence perioperative outcomes and prognosis in patients with right-sided colon cancer compared to those with left-sided colon cancer. Our findings suggest that age and lymph node involvement along with other factors play a role in the overall survival and recurrence outcomes of these patients. Further research is necessary to explore these differences and develop personalized treatment plans for patients with colon cancer.

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Cancers colorectaux en Martinique: incidence et mortalité durant une période de 20 ans

Cited by 7 publications

References 18 publications

Colorectal cancer in patients seen at the teaching hospitals of Guadeloupe and Martinique: discrepancies, similarities in clinicopathological features, and p53 status

Colorectal cancer in patients seen at the teaching hospitals of Guadeloupe and Martinique: discrepancies, similarities in clinicopathological features, and p53 status

Epidemiology, incidence and treatment of rectal cancer in young women case serie about 11 cases (case series)

Left-Sided Colon Cancer and Right-Sided Colon Cancer: Are They the Same Cancer or Two Different Entities?

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