Cancers in Vietnam—Burden and Control Efforts: A Narrative Scoping Review

Pham, Tho Hoan; Bui, Phuong Linh; Kim, Giang; Hoang, Dong Van; Tran, Tien Anh; Hoang, Minh Van

doi:10.1177/1073274819863802

Cited by 86 publications

(83 citation statements)

References 63 publications

(116 reference statements)

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“…This study investigates the previously unexamined experience of women with breast cancer in Vietnam along different points of the diagnostic and treatment pathway. Data on cancer are limited with cancer registries being hospital based and datasets being partly based on mathematical models 1. Previous studies have, however, indicated increased challenges for Vietnamese society and the health system posed by non-communicable diseases, and particularly breast cancer given that it often is diagnosed in later stages 2–5.…”

Section: Introductionmentioning

confidence: 99%

Experiences of accessing and using breast cancer services in Vietnam: a descriptive qualitative study

et al. 2020

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ObjectivesTo understand, describe and analyse the experiences of women with breast cancer in Vietnam when accessing and using breast cancer services.DesignDescriptive qualitative study. Women were interviewed about their experiences from the first time they became aware of symptoms or changes to their body through treatment and post-treatment. This study is the first descriptive study on breast cancer in Vietnam from the perspective of women with a breast cancer diagnosis.ParticipantsWomen (n=13) who had completed or were still receiving treatment for breast cancer, purposively recruited from the north and south of Vietnam.ResultsAn analysis of the experiences of women with breast cancer in Vietnam revealed a lack of awareness and knowledge about breast cancer and symptoms. Family and social support were described as key factors influencing whether a woman accesses and uses breast cancer services. Cost of treatment and out-of-pocket expenditures limited access to services and resulted in significant financial challenges for women and their families.ConclusionsVietnam has made huge strides in improving cancer care, and is tackling a complex and expanding public health challenge, however, there are a number of areas requiring strengthening and future research. While Vietnam has successfully expanded social health insurance coverage, changes that increase the percentage of costs covered for specific treatments, such as chemotherapy or radiotherapy, could benefit women and their families.

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Section: Introductionmentioning

confidence: 99%

Experiences of accessing and using breast cancer services in Vietnam: a descriptive qualitative study

et al. 2020

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“…Vietnam displays higher incidence rate of lung cancer than the average worldwide incidence (14.5% versus 11% of all new cases) despite having the same level of mortality rate according to the latest Globocan data 18,19 . Also, in Vietnam lung cancer is the most aggressive type of cancer in men and ranks as the second leading cause of cancer deaths in women 18,19 . Therefore, it is important to assess the mutation landscape as well as their association with unique clinicopathological features of Vietnamese NSCLC patients.…”

mentioning

confidence: 97%

Actionable Mutation Profiles of Non-Small Cell Lung Cancer patients from Vietnamese population

Dang

Tran²,

Tran³

et al. 2020

Sci Rep

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Comprehensive profiling of actionable mutations in non-small cell lung cancer (NSCLC) is vital to guide targeted therapy, thereby improving the survival rate of patients. Despite the high incidence and mortality rate of NSCLC in Vietnam, the actionable mutation profiles of Vietnamese patients have not been thoroughly examined. Here, we employed massively parallel sequencing to identify alterations in major driver genes (EGFR, KRAS, NRAS, BRAF, ALK and ROS1) in 350 Vietnamese NSCLC patients. We showed that the Vietnamese NSCLC patients exhibited mutations most frequently in EGFR (35.4%) and KRAS (22.6%), followed by ALK (6.6%), ROS1 (3.1%), BRAF (2.3%) and NRAS (0.6%). Interestingly, the cohort of Vietnamese patients with advanced adenocarcinoma had higher prevalence of EGFR mutations than the Caucasian MSK-IMPACT cohort. Compared to the East Asian cohort, it had lower EGFR but higher KRAS mutation prevalence. We found that KRAS mutations were more commonly detected in male patients while EGFR mutations was more frequently found in female. Moreover, younger patients (<61 years) had higher genetic rearrangements in ALK or ROS1. In conclusions, our study revealed mutation profiles of 6 driver genes in the largest cohort of NSCLC patients in Vietnam to date, highlighting significant differences in mutation prevalence to other cohorts. Lung cancer is the most common malignancy and the leading cause of cancer related deaths worldwide (18.4% of total cancer deaths), with non-small cell lung cancer (NSCLC) being the most common subtype, accounting for approximately 85% of all diagnosed cases 1,2. The majority of NSCLC patients display advanced disease when diagnosed and thus have poor prognosis 2,3. It is well established that acquired genetic alterations in certain driver genes result in tumour growth and invasiveness, and that patients harboring certain mutations may benefit from targeted therapies 4,5. Indeed, a randomized clinical trial reported that advanced NSCLC patients harboring activating mutations in EGFR, one of the major driver genes of NSCLC, exhibited longer progression-free period when treated with a tyrosine kinase inhibitor (TKI), gefitinib, compared to those treated with standard platinum based chemotherapy 6. However, those who were treated with TKI drugs can acquire secondary resistant mutations, in which case a new treatment regimen is needed to maintain therapeutic effect 7,8. In addition to EGFR, NSCLC patients carrying ALK or ROS1 rearrangement were shown to respond well to a different TKI drug,

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“…A question raised by this media content analysis concerns the disconnection between information shared in the media regarding breast cancer risk factors, symptoms and expectations for treatment, and reported knowledge by women in other studies. Despite the largely factual and accurate reporting about breast cancer in the mass media, knowledge and awareness about breast cancer is generally poor [4,[28][29][30]. This raises questions about the medium, focus, and delivery of content.…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer messaging in Vietnam: an online media content analysis

Jenkins

Lan³

et al. 2020

BMC Public Health

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Background: Breast cancer incidence is increasing in Vietnam with studies indicating low levels of knowledge and awareness and late presentation. While there is a growing body of literature on challenges faced by women in accessing breast cancer services, and for delivering care, no studies have sought to analyse breast cancer messaging in the Vietnamese popular media. The aim of this study was to investigate and understand the content of messages concerning breast cancer in online Vietnamese newspapers in order to inform future health promotional content. Methods: This study describes a mixed-methods media content analysis that counted and ranked frequencies for media content (article text, themes and images) related to breast cancer in six Vietnamese online news publications over a twelve month period. Results: Media content (n = 129 articles & n = 237 images) sampled showed that although information is largely accurate, there is a marked lack of stories about Vietnamese women's personal experiences. Such stories could help bridge the gap between what information about breast cancer is presented in the Vietnamese media, and what women in Vietnam understand about breast cancer risk factors, symptoms, screening and treatment. Conclusions: Given findings from other studies indicating low levels of knowledge and women with breast cancer experiencing stigma and prejudice, more nuanced and in-depth narrative-focused messaging may be required.

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Cancers in Vietnam—Burden and Control Efforts: A Narrative Scoping Review

Cited by 86 publications

References 63 publications

Experiences of accessing and using breast cancer services in Vietnam: a descriptive qualitative study

Experiences of accessing and using breast cancer services in Vietnam: a descriptive qualitative study

Actionable Mutation Profiles of Non-Small Cell Lung Cancer patients from Vietnamese population

Breast Cancer messaging in Vietnam: an online media content analysis

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