Candida africana in recurrent vulvovaginal candidiasis (RVVC) patients: frequency and phenotypic and genotypic characteristics

Naeimi, Behrouz; Mirhendi, Hossein; Khamisipour, Gholamreza; Sadeghzadeh, Farzaneh; Ahmadi, Bahram

doi:10.1099/jmm.0.000834

Cited by 17 publications

(16 citation statements)

References 51 publications

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“…Both strains of C. africana were isolated from genital samples. This is concordant with that described by other authors [46,48,49]. Although some authors argue that there are no compelling reasons to separate C. dubliniensis or C. africana from C. albicans routinely [50,51], some studies show that the susceptibility of non-albicans species to antifungals could be lower than that of C. albicans [52].…”

Section: Discussionsupporting

confidence: 89%

Identification of Cryptic Species of Four Candida Complexes in a Culture Collection

Fontecha¹,

Montes²,

Ortiz³

et al. 2019

Preprint

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Candida spp. are the most common cause of fungal infections worldwide. The taxonomy of Candida is controversial and has undergone recent changes due to novel genetically related species. Therefore, some complexes of cryptic species have been proposed. In clinical settings, the correct identification of Candida species is relevant since some species are associated with high resistance to antifungal drugs and increased virulence. This study aimed to identify the species of four Candida complexes (C. albicans, C. glabrata, C. parapsilosis, and C. haemulonii) by molecular methods. This is the first report of six cryptic Candida species in Honduras: C. dubliniensis, C. africana, C. duobushaemulonii, C. orthopsilosis, and C. metapsilosis, and it is also the first report of the allele hwp1-2 of C. albicans sensu stricto. It was not possible to demonstrate the existence of C. auris among the isolates of the C. haemulonii complex. We also propose a simple method based on PCR-RFLP for the discrimination of the multi-resistant pathogen C. auris within the C. haemulonii complex.

show abstract

Section: Discussionsupporting

confidence: 89%

Identification of Cryptic Species of Four Candida Complexes in a Culture Collection

Fontecha¹,

Montes²,

Ortiz³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Both strains of C. africana were isolated from genital samples. This is concordant with that described by other authors [48,50,51]. Although some authors argue that there are no compelling reasons to separate C. dubliniensis or C. africana from C. albicans routinely [52,53], some studies show that the susceptibility of non-albicans species to antifungals could be lower than that of C. albicans [54].…”

Section: Discussionsupporting

confidence: 89%

Identification of Cryptic Species of Four Candida Complexes in a Culture Collection

Fontecha

Montes

Ortiz

et al. 2019

JoF

View full text Add to dashboard Cite

Candida spp. are one of the most common causes of fungal infections worldwide. The taxonomy of Candida is controversial and has undergone recent changes due to novel genetically related species. Therefore, some complexes of cryptic species have been proposed. In clinical settings, the correct identification of Candida species is relevant since some species are associated with high resistance to antifungal drugs and increased virulence. This study aimed to identify the species of four Candida complexes (C. albicans, C. glabrata, C. parapsilosis, and C. haemulonii) by molecular methods. This is the first report of six cryptic Candida species in Honduras: C. dubliniensis, C. africana, C. duobushaemulonii, C. orthopsilosis, and C. metapsilosis, and it is also the first report of the allele hwp1-2 of C. albicans sensu stricto. It was not possible to demonstrate the existence of C. auris among the isolates of the C. haemulonii complex. We also propose a simple method based on PCR-RFLP for the discrimination of the multi-resistant pathogen C. auris within the C. haemulonii complex.

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“…africana from the other members of C . albicans complex using conventional identification techniques is difficult [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…africana within the C . albicans complex has been reported to vary significantly from 0 to 8.4% depending on the geographic regions in which analyses were performed [ 11 , 19 , 22 – 24 ]. Furthermore, while some studies have suggested that the susceptibility profiles of C .…”

Section: Introductionmentioning

confidence: 99%

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Distribution, antifungal susceptibility pattern and intra-Candida albicans species complex prevalence of Candida africana: A systematic review and meta-analysis

et al. 2020

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Candida africana is a pathogenic species within the Candida albicans species complex. Due to the limited knowledge concerning its prevalence and antifungal susceptibility profiles, a comprehensive study is overdue. Accordingly, we performed a search of the electronic databases for literature published in the English language between 1 January 2001 and 21 March 2020. Citations were screened, relevant articles were identified, and data were extracted to determine overall intra- C . albicans complex prevalence, geographical distribution, and antifungal susceptibility profiles for C . africana . From a total of 366 articles, 41 were eligible for inclusion in this study. Our results showed that C . africana has a worldwide distribution. The pooled intra- C . albicans complex prevalence of C . africana was 1.67% (95% CI 0.98–2.49). Prevalence data were available for 11 countries from 4 continents. Iran (3.02%, 95%CI 1.51–4.92) and Honduras (3.03%, 95% CI 0.83–10.39) had the highest values and Malaysia (0%) had the lowest prevalence. Vaginal specimens were the most common source of C . africana (92.81%; 155 out of 167 isolates with available data). However, this species has also been isolated from cases of balanitis, from patients with oral lesions, and from respiratory, urine, and cutaneous samples. Data concerning the susceptibility of C . africana to 16 antifungal drugs were available in the literature. Generally, the minimum inhibitory concentrations of antifungal drugs against this species were low. In conclusion, C . africana demonstrates geographical variation in prevalence and high susceptibility to antifungal drugs. However, due to the relative scarcity of existing data concerning this species, further studies will be required to establish more firm conclusions.

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Candida africana in recurrent vulvovaginal candidiasis (RVVC) patients: frequency and phenotypic and genotypic characteristics

Cited by 17 publications

References 51 publications

Identification of Cryptic Species of Four Candida Complexes in a Culture Collection

Identification of Cryptic Species of Four Candida Complexes in a Culture Collection

Identification of Cryptic Species of Four Candida Complexes in a Culture Collection

Distribution, antifungal susceptibility pattern and intra-Candida albicans species complex prevalence of Candida africana: A systematic review and meta-analysis

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