Candida albicans Endophthalmitis after Extracorporeal Shock Wave Lithotripsy in a Patient with Liver Cirrhosis

Toshikuni, Nobuyuki; Ujike, Kazuhiro; Yanagawa, Toshihiro; Suga, Tatsuhito; Shimizu, Toshinari; Kusuda, Yuji; Okamoto, Masayuki; Ogawa, Tomoya; Yuasa, Shiro

doi:10.2169/internalmedicine.45.1761

Cited by 19 publications

(18 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are, of course, several studies that have reported the evaluation of micafungin in human patients. Toshikuni and colleagues reported that co-administration of micafungin with fluconazole eye drops was proved to be more effective in treating C. albicans endophthalmitis than systemic fluconazole treatment in a patient with cirrhosis of the liver [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Histological Effects of Intravitreal Injection of Antifungal Agents in New Zealand White Rabbits: An Electron Microscopic and Immunohistochemical Study

et al. 2020

View full text Add to dashboard Cite

Fungal endophthalmitis is a serious and vision-threatening infection which requires an immediate and effective treatment approach. Our research aims to elucidate the histological effects of the intravitreal injection of the maximum safe dosage of voriconazole and micafungin on retina. Six albino New Zealand White Rabbits were used. In experimental animals, a solution of voriconazole (Group V) or micafungin (Group M) was intravitreally injected in the right eye, while in control animals, balanced salt solution was intravitreally injected in the left eye (Group C). Euthanasia was performed ten days post injection and the retina was removed and prepared for histological examination with a light and electron microscope. Eosin-hematoxylin staining did not reveal any pathological changes in any of the samples examined. The immunohistochemical staining for Tumor Necrosis Factor alpha (TNF-a) marker was detected as negative in all samples, while Interleukin 6 (IL-6) marker was detected as mild only in the group injected with voriconazole. Electron microscopy revealed several ultrastructural alterations in retinal layers in both groups of experimental animals. Histological retinal lesions, revealed with electron microscopy in the present investigation, raises the question of the safe usage of these antifungal agents in the treatment of fungal intraocular infections in the future.

show abstract

Section: Discussionmentioning

confidence: 99%

Histological Effects of Intravitreal Injection of Antifungal Agents in New Zealand White Rabbits: An Electron Microscopic and Immunohistochemical Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Endogenous Candida endophthalmitis is an uncommon, sight-threatening condition with poor visual acuity outcome [1–3]. Predisposing factors that have been reported for ECE include major gastrointestinal intervention, long-term systemic antibiotic use, recent hospitalization, indwelling catheters, candiduria, hyperalimination, prolonged intravenous line, hemodialysis, chronic liver disease, surgical abortion, neutropenia, immunomodulatory therapy, diabetes mellitus, hematopoietic stem cell and organ transplantation, alcoholism, intravenous drug abuse, and HIV [1–7].…”

Section: Discussionmentioning

confidence: 99%

Unilateral endogenous Candida endophthalmitis after extracorporeal shock wave lithotripsy for a renal stone in an immunocompetent woman: a case report

Shirvani

Hosseini

Maalhagh

et al. 2019

J Ophthal Inflamm Infect

View full text Add to dashboard Cite

Purpose To report a case of endogenous Candida endophthalmitis that may cause catastrophic sight-threatening outcomes, after extracorporeal shock wave lithotripsy (ESWL) in a healthy woman. Case presentation A 32-year-old woman presented to the ophthalmology clinic with the symptom of blurred vision and floater in her right eye. She underwent ESWL for renal stone 1 week prior to her presentation. Fundus examination showed an elevated white lesion in para-fovea with fluffy border. Smear of diagnostic vitreous sampling showed pseudo-hypha and budding yeast. Systemic and immunologic and infectious workups were unremarkable. In our case, response to intravitreal and intravenous injection of amphotericin-B and oral fluconazole was dramatic. Six weeks after starting the treatment, infiltrative lesion completely disappeared. The authors review previous MEDLINE literature about this topic. Conclusion Endogenous Candida endophthalmitis following renal stone lithotripsy is a serious and rare intraocular infection that may happen in healthy individuals without any risk factors.

show abstract

“…Toshikuni and associates reported a case of fungal sepsis and C. albicans endophthalmitis after extracorporeal shock wave lithotripsy in a cirrhotic patient [10]. Beck and associates reported two patients with Child-Pugh class B and C liver cirrhosis who had undergone ureteroscopy and holmium laser lithotripsy for obstructing ureteral calculi [11].…”

Section: Discussionmentioning

confidence: 99%

“…Toshikuni and associates suggested that administration of antifungal agents before extracorporeal shock wave lithotripsy might be helpful for preventing fungaemia in patients with funguria [10]. The mechanical trauma to the ureter during extracorporeal shock wave lithotripsy might result in dissemination of C. albicans into the bloodstream from urine, infected stent, or urinary calculi.…”

Section: Discussionmentioning

confidence: 99%

Candida albicansFungaemia following Traumatic Urethral Catheterisation in a Paraplegic Patient with Diabetes Mellitus and Candiduria Treated by Caspofungin

Vaidyanathan

Soni

Hughes

et al. 2013

Case Reports in Infectious Diseases

View full text Add to dashboard Cite

A 58-year-old paraplegic male, with long-term indwelling urethral catheter, developed catheter block. The catheter was changed, but blood-stained urine was drained intermittently. A long segment of the catheter was seen lying outside his penis, which indicated that the balloon of Foley catheter had been inflated in urethra. The misplaced catheter was removed and a new catheter was inserted correctly. Gentamicin 160 mg was given intravenously; meropenem 1 gram every eight hours was prescribed; antifungals were not given. Twenty hours later, this patient developed distension of abdomen, tachycardia, and hypotension; he was not arousable. Computed tomography of abdomen revealed inflamed uroepithelium of right renal pelvis and ureter, 4 mm lower ureteric calculus with gas in right ureter proximally, and vesical calculus containing gas in its matrix. Urine and blood culture yielded Candida albicans. Identical sensitivity pattern of both isolates suggested that the source of the bloodstream infection was most likely urine. Both isolates formed consistently high levels of biofilm formation in vitro as assessed using a biofilm biomass stain, and high levels of resistance to voriconazole were observed. Both amphotericin B and caspofungin showed good activity against the biofilms. HbA1c was 111 mmol/mol. This patient was prescribed human soluble insulin and caspofungin 70 mg followed by 50 mg daily intravenously. He recovered fully from candidemia.

show abstract

Candida albicans Endophthalmitis after Extracorporeal Shock Wave Lithotripsy in a Patient with Liver Cirrhosis

Abstract: Abstract

Cited by 19 publications

References 23 publications

Histological Effects of Intravitreal Injection of Antifungal Agents in New Zealand White Rabbits: An Electron Microscopic and Immunohistochemical Study

Histological Effects of Intravitreal Injection of Antifungal Agents in New Zealand White Rabbits: An Electron Microscopic and Immunohistochemical Study

Unilateral endogenous Candida endophthalmitis after extracorporeal shock wave lithotripsy for a renal stone in an immunocompetent woman: a case report

Candida albicansFungaemia following Traumatic Urethral Catheterisation in a Paraplegic Patient with Diabetes Mellitus and Candiduria Treated by Caspofungin

Contact Info

Product

Resources

About