Candida albicans meningitis in AIDS patient: A case report and literature review

Bourbeau, K.; Gupta, Sonal; Wang, S.

doi:10.1016/j.idcr.2021.e01216

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Systemic candidiasis appears more and more often and constitutes a bigger problem. They are observed in patients with severe immunodeficiency, caused by long-term therapy or diseases which cause a decrease of the immune response, such as cancer or AIDS [ 32 ]. Unfortunately, in recent years, an increase in the number of isolated strains resistant to the antifungal agents used so far has been additionally observed.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Biological Activity and Molecular Docking Studies of Novel Nicotinic Acid Derivatives

Paruch

Biernasiuk

Khyluk

et al. 2022

IJMS

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In our research, we used nicotinic acid as a starting compound, which was subjected to a series of condensation reactions with appropriate aldehydes. As a result of these reactions, we were able to obtain a series of twelve acylhydrazones, two of which showed promising activity against Gram-positive bacteria (MIC = 1.95–15.62 µg/mL), especially against Staphylococcus epidermidis ATCC 12228 (MIC = 1.95 µg/mL). Moreover, the activity of compound 13 against the Staphylococcus aureus ATCC 43300 strain, i.e., the MRSA strain, was MIC = 7.81 µg/mL. Then, we subjected the entire series of acylhydrazones to a cyclization reaction in the acetic anhydride, thanks to which we were able to obtain twelve new 3-acetyl-2,5-disubstituted-1,3,4-oxadiazoline derivatives. Obtained 1,3,4-oxadiazolines were also tested for antimicrobial activity. The results showed high activity of compound 25 with a 5-nitrofuran substituent, which was active against all tested strains. The most promising activity of this compound was found against Gram-positive bacteria, in particular against Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 6538 (MIC = 7.81 µg/mL) and ATCC 43300 MRSA strains (MIC = 15.62 µg/mL). Importantly, the best performing compounds did not show cytotoxicity against normal cell lines. It seems practical to use some of these compounds or their derivatives in the future in the prevention and treatment of infections caused by some pathogenic or opportunistic microorganisms.

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Section: Introductionmentioning

confidence: 99%