Candida albicans: Molecular interactions with Pseudomonas aeruginosa and Staphylococcus aureus

Lindsay, Allia K.; Hogan, Deborah A.

doi:10.1016/j.fbr.2014.10.002

Cited by 41 publications

(39 citation statements)

References 171 publications

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“…Microbial interactions within microbiomes have rarely been experimentally validated due to the challenges of creating ecologically relevant conditions in a laboratory environment and the limited ability to culture all members in complex multispecies microbiomes. When potential pairwise interactions have been carefully measured and dissected mechanistically (19, 53–55), they have rarely been linked to potential patterns of biodiversity and ecological processes occurring in naturally forming microbiomes (56). By integrating observations from metagenomics with in vitro community reconstructions and comparative omics approaches, we have demonstrated that very specific biotic interactions between bacteria and fungi can shape the composition of widely distributed and closely related bacterial species.…”

Section: Discussionmentioning

confidence: 99%

Biotic Interactions Shape the Ecological Distributions of Staphylococcus Species

Kastman

Kamelamela

Norville

et al. 2016

mBio

110

131

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Many metagenomic sequencing studies have observed the presence of closely related bacterial species or genotypes in the same microbiome. Previous attempts to explain these patterns of microdiversity have focused on the abiotic environment, but few have considered how biotic interactions could drive patterns of microbiome diversity. We dissected the patterns, processes, and mechanisms shaping the ecological distributions of three closely related Staphylococcus species in cheese rind biofilms. Paradoxically, the most abundant species (S. equorum) is the slowest colonizer and weakest competitor based on growth and competition assays in the laboratory. Through in vitro community reconstructions, we determined that biotic interactions with neighboring fungi help resolve this paradox. Species-specific stimulation of the poor competitor by fungi of the genus Scopulariopsis allows S. equorum to dominate communities in vitro as it does in situ. Results of comparative genomic and transcriptomic experiments indicate that iron utilization pathways, including a homolog of the S. aureus staphyloferrin B siderophore operon pathway, are potential molecular mechanisms underlying Staphylococcus-Scopulariopsis interactions. Our integrated approach demonstrates that fungi can structure the ecological distributions of closely related bacterial species, and the data highlight the importance of bacterium-fungus interactions in attempts to design and manipulate microbiomes.

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Section: Discussionmentioning

confidence: 99%

Biotic Interactions Shape the Ecological Distributions of Staphylococcus Species

Kastman

Kamelamela

Norville

et al. 2016

mBio

110

131

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“…For example, Staphylococcus aureus and C. albicans are often co-isolated from neonatal polymicrobial bloodstream infections 122 . Biofilms containing C. albicans and Streptococcus mutans or Streptococcus gordonii have been isolated from denture stomatitis and dental carries 123–126 , whereas C. albicans and Pseudomonas aeruginosa are commonly co-isolated from skin and lung infections 127 . Scanning electron microscopy studies of dual-species biofilms has revealed that cells from species such as Staphylococcus epidermidis , Acinetobacter baumannii , Pseudomonas aeruginosa and various Streptococcus species bind to C. albicans hyphal cells present in a biofilm 121,128 (FIG.…”

Section: Polymicrobial Biofilmsmentioning

confidence: 99%

Development and regulation of single- and multi-species Candida albicans biofilms

et al. 2017

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Candida albicans is among the most prevalent fungal species of the human microbiota and asymptomatically colonizes healthy individuals. However, it is also an opportunistic pathogen that can cause severe, and often fatal, bloodstream infections. The medical impact of C. albicans typically depends on its ability to form biofilms, which are closely packed communities of cells that attach to surfaces, such as tissues and implanted medical devices. In this Review, we provide an overview of the processes involved in the formation of C. albicans biofilms and discuss the core transcriptional network that regulates biofilm development. We also consider some of the advantages that biofilms provide to C. albicans in comparison with planktonic growth and explore polymicrobial biofilms that are formed by C. albicans and certain bacterial species.

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“…cystic fibrosis), and skin infections (e.g. burn wounds) [54]. Studies using animal models indicate that co-infection with C. albicans and other bacterial species may increase virulence.…”

Section: Multispecies Biofilms Formed Between C Albicans and Othementioning

confidence: 99%

“…Examples of these types have been observed in studies of the vaginal microbiota, especially in the interactions between C. albicans and Lactobacillus species, as growth of the bacteria produces lactic acid that lowers the local pH, inhibiting the growth of C. albicans on the vaginal mucosal surface [61]. In another example, P. aeruginosa is known to secrete a 12-carbon acyl homoserine lactone that modulates hyphal growth of C. albicans [54]. Evidence of these interactions, taken in context with human health, challenges us to reexamine our thinking and approaches towards microbial infection.…”

Section: Multispecies Biofilms Formed Between C Albicans and Othementioning

confidence: 99%

Candida albicans biofilms: development, regulation, and molecular mechanisms

Gulati

Nobile

2016

Microbes and Infection

535

433

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A major virulence attribute of Candida albicans is its ability to form biofilms, densely packed communities of cells adhered to a surface. These biofilms are intrinsically resistant to conventional antifungal therapeutics, the host immune system, and other environmental factors, making biofilm-associated infections a significant clinical challenge. Here, we review current knowledge on the development, regulation, and molecular mechanisms of C. albicans biofilms.

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Candida albicans: Molecular interactions with Pseudomonas aeruginosa and Staphylococcus aureus

Cited by 41 publications

References 171 publications

Biotic Interactions Shape the Ecological Distributions of Staphylococcus Species

Biotic Interactions Shape the Ecological Distributions of Staphylococcus Species

Development and regulation of single- and multi-species Candida albicans biofilms

Candida albicans biofilms: development, regulation, and molecular mechanisms

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