Candida albicans versus non-albicans bloodstream infections: The comparison of risk factors and outcome

Chi, Hung-Wei; Yang, Ya-Sung; Shang, Shi-Ta; Chen, Ke-Hung; Yeh, Kuo-Ming; Chang, Feng–Yee; Lin, Jung‐Chung

doi:10.1016/j.jmii.2010.08.010

Cited by 87 publications

(75 citation statements)

References 35 publications

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“…A high sensitivity of C. albicans to antifungal agents was observed, corroborating other published works 6,12,31 . As observed in Table 3, among the NCAC species (n=32), 31.2% of the isolates demonstrated SDD to fl uconazole, with 3.1% being resistant to amphotericin B (which corroborates published reports of high resistance of these species to antifungal agents) 9,13 .…”

Section: Discussionsupporting

confidence: 90%

“…In Brazil and in our study, several studies have indicated C. tropicalis as the second most frequent isolate in cases of candidemia among hospitalized patients 12,20,24 . C. tropicalis is the fourth most frequent Candida species isolated in cases of candidemia in the United States 30 and the third most frequent isolate in Spain 8 and Asia 6 . The ability to detect bloodstream infections caused by Candida spp.…”

Section: Discussionmentioning

confidence: 99%

“…There have been, however, increases in HI caused by non-C. albicans Candida (NCAC) species such as C. tropicalis, C. glabrata, C. parapsilosis, and C. krusei [6][7][8] . The occurrence of infections caused by these yeasts is relevant to HI vigilance because these micro-organisms have varying virulence attributes and profi les of antifungal drug sensitivity, including recent reports of resistance to the principal antifungal drugs currently administered in hospitals 9,10 .…”

Section: Introductionmentioning

confidence: 99%

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Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Almeida

Shinobu-Mesquita

Svidzinski

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Hospital infections caused by Candida spp. are a leading cause of morbidity and mortality in hospitalized patients, particularly those that are critically ill or immunocompromised. In this study, the distributio n of Candida species in isolates from the University Hospital of the Federal University at Grande Dourados and their in vitro susceptibility to antifungal drugs were analyzed. Methods: Yeasts were phenotypically identifi ed using classical methodologies. Antifungal susceptibility tests to amphotericin B and fl uconazole were performed using the broth microdilution technique. Results: A total of 50 Candida isolates were obtained from hospitalized patients during the study period. We analyzed yeast isolates from urine (n=31; 62%), blood (n=12; 24%), and tracheal secretions (n=7; 14%). The following Candida species were identifi ed: C. tropicalis (n=21; 42%), C. albicans (n=18; 36%), C. glabrata (n=10; 20%), and C. krusei (n=1; 2%). Antifungal susceptibility tests demonstrated that C. albicans was susceptible to both antifungal agents. However, 31.2% of the non-C. albicans Candida isolates displayed dose-dependent susceptibility to fl uconazole, and 3.1% were resistant to amphotericin B. Conclusions: In contrast to previous reports, our results indicated that C. tropicalis was the most commonly isolated yeast species among the hospital patients. The predominance of non-C. albicans Candida infections confi rms the importance of species-level identifi cation for implementing appropriate antifungal therapies.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Almeida

Shinobu-Mesquita

Svidzinski

et al. 2013

Rev. Soc. Bras. Med. Trop.

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“…In fact, the most common diseases that predispose to an increased sensitivity to C. albicans overgrowth are diabetes mellitus, cancer, leukemia, AIDS, thyroid dysfunction and other diseases, in which host defense mechanisms are suppressed or adrenal cortex steroids/antibiotics/other similar drugs are used (immunosuppressed patients) [6,10,12,24,25,37,40,53,56,[70][71][72].…”

Section: Impaired Immune System and Underlying Disease Statesmentioning

confidence: 99%

Candidiasis: Predisposing Factors, Prevention, Diagnosis and Alternative Treatment

et al. 2014

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SUMMARYCandidiasis is the most common opportunistic yeast infection. Candida species and other microorganisms are involved in this complicated fungal infection, but Candida albicans continues to be the most prevalent. In the past two decades, it has been observed an abnormal overgrowth in the gastrointestinal, urinary and respiratory tracts, not only in immunocompromised patients, but also related to nosocomial infections and even in healthy individuals. There is a widely variety of causal factors that contribute to yeast infection which means that candidiasis is a good example of a multifactorial syndrome. Due to rapid increase in the incidence of these infections, this is the subject of numerous studies. Recently, the focus of attention is the treatment and, above all, the prevention of those complications. The diagnosis of candidiasis could become quite complicated. Prevention is the most effective "treatment", much more than eradication of the yeast with antifungal agents. There are several aspects to consider in the daily routine that can provide a strength protection. However, a therapeutic approach is necessary when the infection is established and, therefore, other alternatives should be explored. This review provides an overview on predisposition factors, prevention and diagnosis of candidiasis, highlighting alternative approaches for candidiasis treatment.

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“…NAC species are of special concern because of their high drug-resistance and increasing prevalence in invasive candidiasis [7]. Several years ago, different studies have been reported about candidemia in hospitals of Saudi Arabia, and these studies have used different designs, prospective vs. retrospective and different patient groups (ICU vs. non-ICU) [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Antifungal susceptibility, risk factors and treatment outcomes of patients with candidemia at a university hospital in Saudi Arabia

Jiman-Fatani¹,

Meawed²,

El-Hossary³

2015

int. arab. j antimicrob. agents

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Background: Candidemia is a major cause of morbidity and mortality in hospitalized patients. The spectrum of candidemia has been changed especially among critically ill patients due to emergence of non-albicans Candida (NAC) species. The increasing use of azole agents is suggested to be responsible for this epidemiological shift. NAC species are of special concern because of their high drug-resistance and increasing prevalence.The aim of this study was to detect antifungal-susceptibility patterns, treatment outcomes and associated risk factors in patients with candidemia who were admitted to King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom of Saudi Arabia (KSA) .

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Candida albicans versus non-albicans bloodstream infections: The comparison of risk factors and outcome

Abstract: The outcome of candidemia was poor. The identified risk factors may help us to differentiate fatal candidemia in early infection.

Cited by 87 publications

References 35 publications

Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Antifungal susceptibility and distribution of Candida spp. isolates from the University Hospital in the municipality of Dourados, State of Mato Grosso do Sul, Brazil

Candidiasis: Predisposing Factors, Prevention, Diagnosis and Alternative Treatment

Antifungal susceptibility, risk factors and treatment outcomes of patients with candidemia at a university hospital in Saudi Arabia

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