Candida and Aids: Evidence for Protective Antibody

Heat-inducible ATP-binding proteins of Candida albicans are recognized by sera of infected patients

“…Unfortunately an insufficient amount of protein was purified by ATP agarose affinity chromatography to carry out large-scale studies. The detection of antibodies against the three described heat-shock proteins in the sera of patients with oral and for oesophageal infection, who rarely get disseminated candidiasis (Matthews & Burnie, 1992), supports the suggestion that protective antibodies play a role in preventing disseminated candidiasis (Matthews et al, 1988). This hypothesis is supported by data with squirrel monkeys infected by Plasmodium falciparum.…”

“…More recently, cytoplasmic proteins have been identified as antigens (Strockbine et al, 1984) and some have been cloned by antibody screening of expression libraries (Franklyn et al, 1990;Shen et al, 1991): at least one of these functions as an allergen (Shen et al, 1991). Studying the antibody response to C. albicans is not only important for the determination of the immunogenic molecules of this pathogen, but it has also been suggested that antibodies may play a role in preventing disseminated candidiasis (Matthews et al, 1988). Antibodies against a 47 kDa protein, which shows homology to hsp90 of Saccharomyces cerevisiae, are protective against systemic infections (Matthews & Burnie, 1992).…”

An immunodominant antigen of Candida albicans shows homology to the enzyme enolase

“…However, mucoeutaneous infections rarely become invasive even in patients who are severely immunocompromised. This suggests that other mechanisms of resistance are important in containing or limiting the infection, and attention has recently turned again to the possible role of antibody in protection from systemic infection (3).…”

“…patients who survived produced a strong antibody response to an antigen of approximately 47 kDa (3,5), whereas in fatal cases the antibody response was weak or absent. The antibody was not found in patients suffering from systemic infections with Candida parapsilosis.…”

Candidoses : bases moléculaires de l’adaptation parasitaire de protistes pathogènes opportunistes

“…Il a pu être démontré, en outre, que l'antigène 48 kDa circulait dans le sérum de patients, lors de processus invasifs sévères. L'existence d'une corrélation entre la présence d'anticorps anti-47 kDa et un état de protection des patients a été décrite sans jusqu'ici avoir reçu de confirmation (9). De même, la possibilité d'une sécrétion de l'antigène 47 kDa au travers de la paroi fongique est encore discutée.…”