Candida guilliermondii as the aetiology of candidosis

Abstract

Candida guilliermondii is one of the components of human microbiota. This yeast has been infrequently associated with human infections, which may be related to its low pathogenicity. The aim of this study was to provide clinical and epidemiological data for patients infected with C. guilliermondii at Santa Casa Complexo Hospitalar, Brazil. From October 1997 to October 2003, C. guilliermondii was isolated from clinical samples from 11 patients. Three patients were excluded because the isolation of the yeast represented colonisation. Specimens from the eight patients included in the study corresponded to blood (n = 5), ascitis fluid (n = 2), and oesophagus biopsy (n = 1). Three patients (37.5%) had major immunosuppressed conditions, including solid organ transplantation, AIDS, and leukaemia. Previous use of antibiotics occurred in 87.5%. Main invasive medical procedures were central venous catheter (50.0%), abdominal surgery (25.0%), and peritoneal dialysis (50.0%). No susceptibility data was obtained. Although risk factors for candidaemia were similar amongst patients infected by with C. guilliermondii or other Candida species, mortality associated with C. guilliermondii was significantly lower.

Fungal Peritonitis Among the Peritoneal Dialysis Patients of Four Turkish Centres

“…Candida species were the most common causative agents for the fungal peritonitis, accounting for 70–89.3% of episodes as the sole pathogen (Manzano‐Gayosso et al 2003; Rosa et al 2006). Moreover, the incidence of invasive infections caused by Candida species has notably increased within the past two decades (Pasqualotto et al 2006). Among Candida species, NAC is 53.6% more common than C. albicans, which is 35.7%.…”

Part 11: Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality

“…guilliermondii and C. rugosa both appear to be increasing in frequency as causes of invasive candidiasis, especially in Latin America (19,20,68,79,80). Both species have been responsible for clusters of infections in hospital settings, and both demonstrate decreased susceptibilities to amphotericin B, fluconazole, and the echinocandins (Table 2) (19,20,24,26,27,36,48,49,70,79,80).…”

“…guilliermondii (teleomorph, Pichia guilliermondii) is known to be a normal component of the human skin and mucosal flora (51,57) and is rarely associated with invasive infections such as endocarditis (104), pericarditis (105), osteomyelitis (103), and peritonitis and fungemia (27,36,48,49,68,70,79). Infection with this species is often catheter-related and has been found to be more common among patients with cancer than among the general hospital population (27,48).…”

Molecular evidence on the occurrence of co-infection with Pichia guilliermondii and Wuchereria bancrofti in two filarial endemic districts of India

“…Although rare, non-albicans Candida (NAC) spp . are emerging as potential opportunistic pathogens, among which Pichia guilliermondii (formerly known as Candida guilliermondii or Meyerozyma guilliermondii ) is one of the 15 yeast species related to human diseases [9,10]. It is commonly isolated from clinical specimens such as phlegm, wounds, sputum, and blood [11].…”