Candida-Related Immune Response Inflammatory Syndrome Treated with Adjuvant Corticosteroids and Review of the Pediatric Literature

Genc, Dildar Bahar; Vural, Sema; Urgancı, Nafiye; Kurtaraner, Tuğçe; Dalgıç, Nazan

doi:10.4274/tjh.2016.0237

Cited by 3 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found the details of 18 children managed with corticosteroids either as case reports or case series. 1,4,8,10,12 Another at least 10 children were reported from larger studies but their data were not complete. Median age was 10.5 years (1.5-18 years).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic Disseminated Candidiasis in Children and the Role of Corticosteroids Therapy

Yazidi¹,

Elsidig²,

Wali³

et al. 2023

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

Background: Little is known about chronic disseminated candidiasis (CDC) in children. This study was done to describe the epidemiology, risk factors and outcome of CDC in children managed at Sultan Qaboos University Hospital (SQUH), Oman, and to describe the role of corticosteroids in the management of immune reconstitution inflammatory syndrome (IRIS) complicating CDC. Methods: We retrospectively reported demographic, clinical and laboratory data of all children managed in our center for CDC between January 2013 and December 2021. In addition, we discuss the available literature on the role of corticosteroids for management of CDC-related IRIS in children since 2005. Results: Between January 2013 and December 2021, 36 immunocompromised children were diagnosed with invasive fungal infection at our center, of whom 6 had CDC (all with acute leukemia). Their median age was 5.75 years. Prolonged fever despite broad-spectrum antibiotics (6/6) followed by skin rash (4/6) were the most common clinical features of CDC. Four children grew Candida tropicalis from blood or skin. CDC-related IRIS was documented in 5 children (83%) and 2 received corticosteroids. Our literature review revealed that 28 children were managed with corticosteroids for CDC-related IRIS since 2005. The majority of these children had defervescence of fever within 48 hours. Prednisolone of 1–2 mg/kg/day for 2–6 weeks was the most common regimen used. No major side effects reported in these patients. Conclusion: CDC is more common in children with acute leukemia and CDC-related IRIS is not uncommon. Corticosteroid therapy looks effective and safe as adjunctive therapy for CDC-related IRIS.

show abstract

Section: Discussionmentioning

confidence: 99%

“…of invasive candidiasis, which mainly affects patients with acute leukemia. [1][2][3][4] It is an important cause of morbidity and mortality in this population. 2,4 Although this condition has been described for more than 50 years, its diagnosis and management are not well established yet.…”

mentioning

confidence: 99%

Chronic Disseminated Candidiasis in Children and the Role of Corticosteroids Therapy

Yazidi¹,

Elsidig²,

Wali³

et al. 2023

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

show abstract

“…Due to adverse effects (mostly immunosuppressive effects), the use of corticosteroids in IFD-IRIS is still controversial. However, addition of corticosteroids to antifungal therapy in CDC-associated IRIS was shown to be safe and to lead to rapid clinical improvement, especially cessation of fever, in all reported cases [5,[9][10][11][12][13][14][15]. It also allowed for the planned treatment for the underlying haematological disease to continue.…”

Section: Discussionmentioning

confidence: 99%

A case of chronic disseminated candidiasis in metamizole-induced neutropaenia

2022

View full text Add to dashboard Cite

Chronic disseminated candidiasis (CDC) is a severe complication of a disseminated yeast infection mainly seen after prolonged chemotherapy-induced neutropaenia in the context of haematological malignancy. We present a case of CDC in a patient with metamizole-induced neutropaenia. To the best of our knowledge, this is the first case described in this context. Furthermore, we highlight the role of steroids in the management of this disease.

show abstract

“…6 The IRIS refers to a clinical deterioration that occurs during immune recovery, due to an exaggerated inflammatory response that reveals previously undetected, clinically silent infection. 3,6 CDC-related IRIS is a very rare condition that should be considered in children with persistent fever, exaggerated inflammatory response, and persistent symptoms on antifungal therapy once other causes were excluded. 4 The diagnosis of CDC-related IRIS is still one of exclusion, as there are no available diagnostic tests to confirm it.…”

Section: Denouementmentioning

confidence: 99%

Disseminated Abscesses in a Child

Al Yazidi,

Elsidig,

Al Rawas

et al. 2024

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

Candida-Related Immune Response Inflammatory Syndrome Treated with Adjuvant Corticosteroids and Review of the Pediatric Literature

Cited by 3 publications

References 11 publications

Chronic Disseminated Candidiasis in Children and the Role of Corticosteroids Therapy

Chronic Disseminated Candidiasis in Children and the Role of Corticosteroids Therapy

A case of chronic disseminated candidiasis in metamizole-induced neutropaenia

Disseminated Abscesses in a Child

Contact Info

Product

Resources

About