Candida utilis: a rare cause of septicemia in children

Sreelekshmi, T S; Ninan, Marilyn M.; Premanand, Arul; Chacko, Anila; Sahni, Rani Diana; Michael, Joy S.

doi:10.1099/acmi.0.000281

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…The high permissiveness coefficient allows rapid multiplication of K. aerogenes, but only if it passes the barriers of other tissues, in which multiplication is much more difficult. Candida utilis interacts with various human tissues in immunocompromised patients [Sreelekshmi et al, 2021]. The biothermodynamic background of this interactions can be explained in a similar way to that with bacteria-host and virus-host interactions.…”

Section: Discussionmentioning

confidence: 95%

Brief History of Thermodynamic Research on Microorganisms

Popovic¹

2023

Preprint

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Pathogen-host interaction (virus-host, bacteria-host and fungi-host) is analyzed from the perspective of biothermodynamics. A mechanistic model of pathogen-host interactions, which was earlier applied to virus-host interactions, was applied for the first time to bacteria-host and fungi-host interactions. Through a mechanistic model suggested in this research, it is possible to explain the phenomenon of tropism of microorganisms to develop infections in certain tissues. Gibbs energy of biosynthesis represents the driving force for growth of bacteria inside host organisms. A growing bacterial colony represents a thermodynamic system, while the host organism is its surroundings. The permissiveness coefficient determines the possibility of growth of bacteria in an appropriate environment (tissue).

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Section: Discussionmentioning

confidence: 95%

Brief History of Thermodynamic Research on Microorganisms

Popovic¹

2023

Preprint

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“…Environmental interactions indicate a potentially pathogenic species, resistant to extreme temperatures and high osmotic levels, as observed by Lapeña et al [36], who related thermotolerance of C. utilis induced by changes in light-dark cycles. This species, considered non-pathogenic, and largely used in the food industry, was cited by some authors as the causal agent of candidemia and in some cases, resistant to antifungal drugs [37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Screening of Candida spp. in wastewater in Brazil during COVID-19 pandemic: workflow for monitoring fungal pathogens

Corrêa-Moreira,

da Costa,

de Lima Neto

et al. 2024

BMC Biotechnol

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Fungal diseases are often linked to poverty, which is associated with poor hygiene and sanitation conditions that have been severely worsened by the COVID-19 pandemic. Moreover, COVID-19 patients are treated with Dexamethasone, a corticosteroid that promotes an immunosuppressive profile, making patients more susceptible to opportunistic fungal infections, such as those caused by Candida species. In this study, we analyzed the prevalence of Candida yeasts in wastewater samples collected to track viral genetic material during the COVID-19 pandemic and identified the yeasts using polyphasic taxonomy. Furthermore, we investigated the production of biofilm and hydrolytic enzymes, which are known virulence factors. Our findings revealed that all Candida species could form biofilms and exhibited moderate hydrolytic enzyme activity. We also proposed a workflow for monitoring wastewater using Colony PCR instead of conventional PCR, as this technique is fast, cost-effective, and reliable. This approach enhances the accurate taxonomic identification of yeasts in environmental samples, contributing to environmental monitoring as part of the One Health approach, which preconizes the monitoring of possible emergent pathogenic microorganisms, including fungi.

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“…Three references related to possible concerns for human safety were identified by Mohzari (2021), Sreelekshmi et al. (2021) and Sharma and Chauhan (2020).…”

Section: Assessmentmentioning

confidence: 99%

Update of the list of QPS‐recommended microbiological agents intentionally added to food or feed as notified to EFSA 16: suitability of taxonomic units notified to EFSA until March 2022

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2022

EFS2

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The qualified presumption of safety (QPS) approach was developed to provide a regularly updated generic pre‐evaluation of the safety of microorganisms, intended for use in the food or feed chains, to support the work of EFSA's Scientific Panels. The QPS approach is based on an assessment of published data for each agent, with respect to its taxonomic identity, the body of relevant knowledge, safety concerns and occurrence of antimicrobial resistance. Safety concerns identified for a taxonomic unit (TU) are, where possible, confirmed at the species/strain or product level and reflected by ‘qualifications’. In the period covered by this statement, no new information was found that would change the status of previously recommended QPS TUs. Of the 50 microorganisms notified to EFSA in October 2021 to March 2022 (inclusive), 41 were not evaluated: 10 filamentous fungi, 1 Enterococcus faecium , 1 Clostridium butyricum, 3 Escherichia coli and 1 Streptomyces spp. because are excluded from QPS evaluation, and 25 TUs that have already a QPS status. Nine notifications, corresponding to seven TUs were evaluated: four of these, Streptococcus salivarius, Companilactobacillus formosensis, Pseudonocardia autotrophica and Papiliotrema terrestris , being evaluated for the first time. The other three, Microbacterium foliorum, Pseudomonas fluorescens and Ensifer adhaerens were re‐assessed. None of these TUs were recommended for QPS status: Ensifer adhaerens, Microbacterium foliorum, Companilactobacillus formosensis and Papiliotrema terrestris due to a limited body of knowledge , Streptococcus salivarius due to its ability to cause bacteraemia and systemic infection that results in a variety of morbidities, Pseudonocardia autotrophica due to lack of body of knowledge and uncertainty on the safety of biologically active compounds which can be produced, and Pseudomonas fluorescens due to possible safety concerns .

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Candida utilis: a rare cause of septicemia in children

Cited by 6 publications

References 9 publications

Brief History of Thermodynamic Research on Microorganisms

Brief History of Thermodynamic Research on Microorganisms

Screening of Candida spp. in wastewater in Brazil during COVID-19 pandemic: workflow for monitoring fungal pathogens

Update of the list of QPS‐recommended microbiological agents intentionally added to food or feed as notified to EFSA 16: suitability of taxonomic units notified to EFSA until March 2022

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