Candidate Anti-COVID-19 Medicinal Plants from Ethiopia: A Review of Plants Traditionally Used to Treat Viral Diseases

Tegen, Dires; Dessie, Kindalem; Damtie, Destaw

doi:10.1155/2021/6622410

Cited by 31 publications

(25 citation statements)

References 84 publications

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“…Except for the development of vaccines, there is no specific drug to treat COVID-19. 26 At present, traditional medicine practice for COVID-19 seems to be usual all over the world. A series of herbs are believed to be effective in relieving or treating symptoms.…”

Section: Discussionmentioning

confidence: 99%

Traditional Medicine Practice in the Context of COVID-19 Pandemic: Community Claim in Jimma Zone, Oromia, Ethiopia

Chali¹,

Melaku²,

Berhanu³

et al. 2021

IDR

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Purpose: To assess traditional medicine practice claims by the community for the prevention and treatment of COVID-19. Methods: A community-based cross-sectional study design was conducted among 422 households of Jimma Zone, and the data were collected by interviewing individuals from the selected households. The medicinal plants were recorded on Microsoft excel 2010 with their parts used, dosage form, route of administration and source of plants and tabulated in the table. Descriptive statistics were used to describe and organize the data. The Relative Frequency of Citation (RFC) was calculated for each traditional medicine to identify the top 10 medicinal products. Results: Around 46% of participants used traditional medicines for the prevention and treatment of COVID-19. The study recorded 32 herbal and non-herbal medicinal products. Garlic (RFC: 0.166), ginger (RFC: 0.133), lemon (RFC: 0.133), garden cress (RFC: 0.069) and "Damakase" (RFC: 0.031) were the frequently used herbal medicines. Seeds (47.22%) and leaves (30.56%) were the most used parts of medicinal plants. Most preparation of medicinal plants (90.63%) was administered through the oral route. The majority of medicinal plants were from home gardens. Conclusions and Recommendations: Around half of the participants practiced traditional medicines for COVID-19. Garlic, ginger, lemon, garden cress and "Damakase" were the frequently used herbal products. Seeds and leaves were regularly used parts. The oral route is the most used route of administration. The majority of medicinal plants were from home gardens. This quantity of traditional medicine practice is probably challenging to control the pandemic. However, it might open possibilities for pharmaceutical industries and researchers to look into the effectiveness and safety of claimed medicinal products. Therefore, all responsible bodies are advocated to behave accordingly.

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Section: Discussionmentioning

confidence: 99%

Traditional Medicine Practice in the Context of COVID-19 Pandemic: Community Claim in Jimma Zone, Oromia, Ethiopia

Chali¹,

Melaku²,

Berhanu³

et al. 2021

IDR

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“…Since antiviral medicinal plants and their bioactive compounds are potential sources that may play a significant role in the development of COVID-19 biotherapeutics [28] , [29] , [30] , [31] , we documented some plant lectins from reported antiviral medicinal plants available in Bangladesh in Table 1 .…”

Section: Introductionmentioning

confidence: 99%

Plant lectins as prospective antiviral biomolecules in the search for COVID-19 eradication strategies

Ahmed

Jahan

Nissapatorn

et al. 2022

Biomedicine & Pharmacotherapy

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Lectins or clusters of carbohydrate-binding proteins of non-immune origin are distributed chiefly in the Plantae. Lectins have potent anti-infectivity properties for several RNA viruses including SARS-CoV-2. The primary purpose of this review is to review the ability of lectins mediated potential biotherapeutic and bioprophylactic strategy against coronavirus causing COVID-19. Lectins have binding affinity to the glycans of SARS-COV-2 Spike glycoprotein that has N-glycosylation sites. Apart from this, the complement lectin pathway is a “first line host defense” against the viral infection that is activated by mannose-binding lectins. Mannose-binding lectins deficiency in serum influences innate immunity of the host and facilitates infectious diseases including COVID-19. Our accumulated evidence obtained from scientific databases particularly PubMed and Google Scholar databases indicate that mannose-specific/mannose-binding lectins (MBL) have potent efficacies like anti-infectivity, complement cascade induction, immunoadjuvants, DC-SIGN antagonists, or glycomimetic approach, which can prove useful in the strategy of COVID-19 combat along with the glycobiological aspects of SARS-CoV-2 infections and antiviral immunity. For example, plant-derived mannose-specific lectins BanLac, FRIL, Lentil, and GRFT from red algae can inhibit and neutralize SARS-CoV-2 infectivity, as confirmed with in-vitro , in-vivo , and in-silico assessments. Furthermore, Bangladesh has a noteworthy resource of antiviral medicinal plants as well as plant lectins. Intensifying research on the antiviral plant lectins, adopting a glyco-biotechnological approach, and with deeper insights into the “glycovirological” aspects may result in the designing of alternative and potent blueprints against the 21st century's biological pandemic of SARS-CoV-2 causing COVID-19

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“…In Ethiopia, medicinal plants are a fundament in the traditional healthcare system, play a major role in maintaining rural livelihoods as a non-timber forest product, and be an incentive to conserve forests (Tuasha et al 2018; Guchale 2021; Agize and van der Zouwen 2016). It is estimated that 80% of the Ethiopian population depend on traditional medicines for the healthcare of not only humans, but also livestock animals (Tuasha et al 2018;Tegen et al 2021). Due to the economic affordability, e cacy against certain diseases, and the trust communities have in the medicinal values of traditional medicines, medicinal plants are constantly in demand in Ethiopia (Bekele 2007;Tegen et al 2021).…”

Section: Introductionmentioning

confidence: 99%

“…It is estimated that 80% of the Ethiopian population depend on traditional medicines for the healthcare of not only humans, but also livestock animals (Tuasha et al 2018;Tegen et al 2021). Due to the economic affordability, e cacy against certain diseases, and the trust communities have in the medicinal values of traditional medicines, medicinal plants are constantly in demand in Ethiopia (Bekele 2007;Tegen et al 2021). Since the outbreak of the COVID-19 pandemic, there has been a race to nd potential medicinal plants to treat the consequent respiratory disease, including in Ethiopia (Tegen et al 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Due to the economic affordability, e cacy against certain diseases, and the trust communities have in the medicinal values of traditional medicines, medicinal plants are constantly in demand in Ethiopia (Bekele 2007;Tegen et al 2021). Since the outbreak of the COVID-19 pandemic, there has been a race to nd potential medicinal plants to treat the consequent respiratory disease, including in Ethiopia (Tegen et al 2021). Among the 56 medicinal plants with antiviral properties identi ed by Tegen et al (2021), Artemisia annua species was found as a candidate due to its artemisinin content.…”

Section: Introductionmentioning

confidence: 99%

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Marketing and Value Addition of Artemisia Annua Species and Other Potential Medicinal Plants in Southern Ethiopia

Gelgelo¹,

Nunie²,

Mekonnen³

et al. 2021

Preprint

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Background: Medicinal plants play a pivotal role in the traditional medicine system in Ethiopia. Since the outbreak of the COVID-19 pandemic, domestic demand for medicinal plants has increased, particularly for Artemisia annua species. However, coupled with the secrecy nature in medicinal plant utilization, knowledge regarding marketing and value addition of medicinal plants is lacking in the literature. The objective of the present market study was to investigate the marketing and value addition of Artemisia annua and other major medicinal plants in selected towns of Southern Ethiopia. Methodology: Primary data were collected using questionnaire, focus group discussions, and personal observations with producers and traders. Marketing benefits of the potential medicinal plants were captured by total return and marketing margins. Result: The major medicinal plants in Chencha area were Artemisia annua, Stevia rebaudiana, and Silybum marianum, Echinops kebericho and Silene macrosolen Steud are widely used in Tula and Hawassa; Ocimum tenuiflorum and Ruta graveolens were found in Basha area, while Zehneria scabra was found in Chencha and Basha. The above-mentioned medicinal plants are used to treat various illnesses, while generating income to the local communities. The marketing or profit margins of the value-added products indicated a share of 28.6%, 14.36%, 14.31%, and 42.73% for producers, local collectors, and traders in Arbaminch and Addis Ababa, respectively. Conclusion: Up scaling the cultivation and commercialization of these medicinal plants has the potential to maintain the public health while providing alternative income sources for local communities in Ethiopia. In an effort to capture local value addition of medicinal plants, processing materials, market outlets, and road infrastructures should be improved.

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Candidate Anti-COVID-19 Medicinal Plants from Ethiopia: A Review of Plants Traditionally Used to Treat Viral Diseases

Cited by 31 publications

References 84 publications

Traditional Medicine Practice in the Context of COVID-19 Pandemic: Community Claim in Jimma Zone, Oromia, Ethiopia

Traditional Medicine Practice in the Context of COVID-19 Pandemic: Community Claim in Jimma Zone, Oromia, Ethiopia

Plant lectins as prospective antiviral biomolecules in the search for COVID-19 eradication strategies

Marketing and Value Addition of Artemisia Annua Species and Other Potential Medicinal Plants in Southern Ethiopia

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